Sentences with phrase «models of disease makes»

«The ongoing line of work with this drug is an excellent example of the bench getting even closer to the bedside — our lab work with the drug in patient - derived xenograft models of disease makes possible the clinical trials taking place at the University of Colorado Hospital next door,» Jimeno says.

Not exact matches

Creating and maintaining a healthy lifestyle that you stick to beyond the birth will also make you a model of healthy living for your child, helping him / her to avoid obesity, diabetes, heart disease and other conditions for a lifetime.

Zebrafish are commonly used to model human diseases, in part because their larvae are transparent, making it easy to see the effects of genetic mutations or drugs.

«Computational models like this one might one day be able to predict the clinical course of a disease or injury, as well as make it possible to do less expensive testing of experimental drugs and interventions to see whether they are worth pursuing with human trials,» he said.

Their mathematical model also predicted how the Disneyland outbreak helped push California back from the tipping point by making parents more afraid of the disease than the vaccine.

«When the Novartis Institutes for BioMedical Research was first founded, we set up a model that would make biology more rational by understanding the molecular pathways of disease,» Elton says.

«While it seems that genetics makes a substantial difference to the severity of the heart disease in our models, it does suggest that in humans we may be able to better diagnose heart valve disease in people with rheumatoid arthritis in the future.»

This is important because it makes it possible to model almost any autoimmune disease, evaluate new drug therapies, and even identify novel targets in the emerging area of cancer immunotherapies.

The success of both vaccines thus far in stringent monkey models has led Picker and his colleagues to believe their CMV - based approach to making vaccines has the potential to be engineered to tackle a variety of infectious diseases.

The findings are the culmination of years of investigation that were triggered when O'Banion and his colleagues made a surprising discovery while studying mouse models of Alzheimer's disease.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

Izpisua Belmonte and colleagues injected the RNA into the eggs and early embryos of mice that harbor two varieties of mitochondrial DNA, making them a suitable model for testing the reduction of a disease mutation.

Yet despite achieving some encouraging results in animal models of MS, drugs that block the activity of TNF tend not work in patients with MS.. In fact, they usually make symptoms worse, and they may even have caused the disease in people predisposed to it, says Fugger.

The study, published Feb. 16 in PLOS Biology, made use of a mutant zebrafish strain that models human Hirschsprung disease, which is caused by loss of the gut neurons that coordinate gut contractions.

The discovery was made by developing a mouse model of the disease that enabled researchers to track which of 15 genetic groups — or subclones — of myeloma cells spread beyond their initial site in the animals» hind legs.

Using a model of Parkinson's disease in which the toxin MPTP, made famous in book «The Case of the Frozen Addicts,» induces Parkinson's - like symptoms in humans and mice, Dr. Smeyne showed that mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.

But Franklin and others suspect that in their zeal to clean up, facilities may have wiped out some of the microbial complexity that makes mice useful models for human disease.

Investigators led by Suma Prakash, MD, FRCPC, MSc (Case Western Reserve University) wondered whether a model called the «behavioral stage of change» model, which was originally used to help people quit smoking, might help patients with chronic kidney disease take action and make decisions about their dialysis options.

It's now possible to not only model disease using the cells, but also to compare iPSCs from humans to those of our closest living relatives --- great apes, with which we share a majority of genes --- for insight into what molecular and cellular features make us human.

Making these data publicly available to researchers will build upon the past success of NHGRI's rapid data access model, and will continue to expand our knowledge of human health and disease.»

«This model, when combined with a rare genetic disease, revealed for the first time how a protein known to prevent tumor growth in most cases, p53, may instead drive bone cancer when genetic changes cause too much of it to be made in the wrong place.»

However, Takebe's liver bud has the advantage of being grown from iPS cells, rather than, for example, the primary human hepatocytes used in Bhatia's graft, which could make it useful in modelling rare diseases or examining the specific genetic backgrounds of the iPS cell donors.

The similarity of the mouse and human genetic make - up means that genes associated with disease in humans can be studied and further investigated in mouse models.

Bar Harbor, Maine — October 21, 2004 — The Jackson Laboratory is pleased to announce that it has received support from the Spinal Muscular Atrophy Foundation to make available the first group of mouse models for spinal muscular atrophy (SMA), a neuromuscular disease and the leading genetic cause of death among infants and toddlers.

Additionally, the inflammatory profile of endometriosis in this animal model mirrors what has been reported in human disease [35 - 37] making this an excellent parallel study for our currently reported data.

This model is particularly amenable to gene editing technology, which makes it possible to design cells with specific disease - relevant mutations — a boon for those studying the cause and progression of metabolic diseases of the liver.

This makes a strong case for the utility of lineage through program cells for diseased modeling.

«Our decision to procure these knockout mouse lines and data and make them available to the research community will yield tremendous benefits, both in the short and long terms,» said NIH Director Elias A. Zerhouni, M.D. «This trans - NIH initiative will place important mouse models into the hands of researchers, speeding advances in the understanding of human disease and the development of new therapies.

The genetic traits of fruit flies make them living models for exploring behavioral, development, genetic and metabolic conditions and diseases in humans.

If successful, this model of making human genomic data accessible to the world might become a paradigm for other diseases, as a way to catalyze scientific advances throughout all fields of human biology.

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

Injecting breast cancer with oxygen - filled microbubbles makes tumors three - times more sensitive to radiation therapy and improves survival in animal models of the disease.

Most of the study's experiments were done in the roundworm C. elegans, which have an SMN gene and motor neurons — those that connect to muscle — that are very similar to humans, making them valuable models in which to study this disease.

The track record of animal models for predicting therapies that will work in people has been poor, making drug discovery for neurodegenerative diseases very costly — and therefore less attractive to drug companies.

This work offers a model for making sense of the thousands of genetic loci associated with disease that are not yet fully understood.

It makes of the mouse a model of choice to study very numerous diseases.

Yet while autism begins during brain development, and it makes sense that a developing organoid could serve as a model, looking at diseases that affect people toward the end of their lives would seem more difficult.

WASHINGTON (January 16, 2017)-- A synthesized steroid mirroring one naturally made by the dogfish shark prevents the buildup of a lethal protein implicated in some neurodegenerative diseases, reports an international research team studying an animal model of Parkinson's disease.

Drug screening with tissue constructs Once they understand the basic cellular biophysics of failing heart tissue, they will transfer their work to tissue models that will make it much faster and safer to test drugs for heart failure and hypertensive heart disease, the scientists say.

The mouse makes an excellent model for human disease because the organization of their DNA and their gene expression is similar to humans, with ninety - eight percent of human genes having a comparable gene in the mouse.

Over the last few years, a number of review articles have made the case that identical twins are the ideal model for examining the link between epigenetics and disease.

«This technology should allow us to very rapidly model neurodegenerative diseases in a dish by making nerve cells from individual patients in just a matter of days — rather than the months required previously,» said Dr. Lipton.

Researchers have managed to insert that gene into mice to make a living, breathing model of a human disease that mice would otherwise never acquire.

Studying these models allowed the research team to see how the LRRK2 mutation kick starts neurodegeneration — making this an extremely powerful model of Parkinson's disease.

«Infectious disease can mean making trade - offs between the risks and rewards of meeting others,» says Eli Fenichel, Arizona State University assistant professor and co-organizer of a transdisciplinary working group at NIMBioS that has developed a better model for understanding the role human decisons play in the spread of disease.

Their skills helped to make the London 2012 Olympics such a resounding success, and their abilities to model subtle changes in a design allows scientists to investigate more effective ways to prevent the spread of diseases.

While closing to the public for any period of time is not a decision any shelter can make lightly, as the field of shelter medicine evolves, continuing to explore this and other models for rapid containment of disease may benefit all creatures — large and small.

The model behind it... that traditional medicine, evidence based, medicine is outstanding at addressing acute diseases, but alternative and more ancient models of medicine has something to offer with chronic diseases, makes a great deal of sense.

In Singapore, cancer is still seen as a terminal disease with little hope of recovery, and there is also a stigma against psychological counselling and psychiatric support, facilitated by the general stigma against mental illness amongt both patients and, paradoxically, healthcare professionals.67 Furthermore, a family - centred model of decision - making tends to be predominant in Asian populations, 68 and in Singapore this is further encouraged by public policy such as healthcare subsidies that are based on a calculation of the immediate family's total income, rather than individual income.69 Beliefs or expectations of the role that the family caregiver ought to play may thus exist and may influence the way individuals respond to the intervention.

They have taken the treatment of anxiety disorders far beyond the disease model that CBT has been stuck in by brilliantly examining the core psychological processes that make fear and anxiety disordered and explaining in clear language what all anxiety disorders have in common.