Sentences with phrase «models of disease such»

Although stem cell therapy is fairly new to veterinary medicine, it has been demonstrated to be an effective treatment in numerous animal models of disease such as osteoarthritis, tendon repair, fractures, muscular dystrophy, autoimmune problems, and other disorders.

Duke s research will use patented multielectrode technology to directly measure the activity of hundreds of neurons to study brain dynamics in unique preclinical models of diseases such as Parkinson s and schizophrenia.

Not exact matches

Although the observational studies that underlie our models all adjusted for multiple confounders, including known risk factors for the disease outcomes of interest, risk factors for early breastfeeding cessation such as preterm birth, preeclampsia, and obesity are also risk factors for metabolic disease in later life.

We do not cover developments of interest only to specialists, such as new animal models of a disease or the opening of new science research centres.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

Currently, I work on three directions: (1) cell motility and the cytoskeleton, (2) modeling of physiology and diseases (such as autoimmune diabetes), and (3) swarming and aggregation behaviour in social organisms.

But epidemiologists are increasingly turning to agent - based models to include factors that the equations ignore, such as geography, transportation networks, family structure, and behavior change — all of which can strongly affect how disease spreads.

He says they hope to be able to create miniature models of brains experiencing a range of diseases, such as Parkinson's and Alzheimer's.

Satellite imagery is used for all sorts of climate study, from identifying conditions that allow infectious diseases like West Nile virus and cholera to emerge, to creating models for predicting hurricanes, to distinguishing natural resources such as wind, water and sunlight.

The new research investigated the effectiveness of MSC therapy in a mouse model of chronic inflammatory lung disease, which reflects some of the essential features of diseases such as COPD and cystic fibrosis.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Modern geographers and cartographers are involved in diverse projects: tracking fleets of vehicles or products, helping customers locate a Dunkin' Donuts, modeling environmental scenarios such as oil spills, and studying the spread of disease.

Some studies blame a parasite - stress model: High infectious disease rates can exacerbate tensions such as xenophobia and strain resources, elevating the risk of conflict.

Flaherty, who studies conditions such as hypergraphia (an uncontrollable urge to write) and writer's block, also looks to disease models to explain the drive behind this mode of communication.

He hopes the model will be useful for future predictions along these lines, such as looking at pathways of disease progression.

Researchers at RTI International will continue to further refine their model to incorporate other national health issues, such as obesity, and to also assess how positive interventions could alter the course of kidney disease in America.

A new Journal of Internal Medicine article proposes that artificial intelligence tools, such as machine learning algorithms, have the potential for building predictive models for the diagnosis and treatment of diseases linked to imbalances in gut microbial communities, or microbiota.

The new Penn - developed model replaces a previous model that only examined pre-operative features such as a history of chronic obstructive pulmonary disease, congestive heart failure, or coronary artery disease.

The most important advancement in medicine in the last 25 years was the development of genetic modeling in animals, enabling us to figure out how fundamental mechanisms of physiology and disease work, such as in bone loss.

«Additionally, the genetically - engineered mouse model will allow us to test potential treatments aimed at correcting achlorhydria, not just for gastric NETS, but also for other diseases of the gastrointestinal system such as Barrett's esophagus (chronic inflammation of the lower part of the esophagus), or hiatus hernia,» says Dr Calvete.

Potential outbreaks of diseases such as Ebola and Lassa fever may be more accurately predicted thanks to a new mathematical model developed by researchers at the University of Cambridge.

Such ease of use will likely encourage the use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workshop).

First, the researchers developed a model of Parkinson's in zebrafish — the first such animal model of the disease — and exposed them to ziram so that they lost dopamine.

«Computer modeling, also known as in silico modeling, of such a complex disease allows us to work toward potential treatments much more rapidly.»

«The model also suggests ongoing warming of global temperatures will likely influence the ecology and distribution of such medically important ticks, favoring more tick - borne diseases among people and pets.

While ADNI researchers use maps such as these to study the pattern and range of degeneration among groups of patients over time, this model could also be used to monitor the progress of the disease in a single patient.

With their experimental collaborators, the researchers are now exploring whether the algorithm can model more complex biological processes, such as the dynamics of insulin secretion in the pancreas and its relationship to the onset of a disease like diabetes.

Now, the same groups have built more elaborate models that paint a detailed picture of how the British countryside was ravaged by the FMD virus, taking into account things such as the location of every farm, the estimated number of pigs, cattle, and sheep each farm contained, as well as exhaustive data about the spread of the disease and the culling process.

«In the future, such efforts could allow us to much better understand human - microbiome interactions, model malnutrition disorders and inflammatory diseases of the gut, and perform personalized drug testing,» said co-first author Alessio Tovaglieri, a Graduate Student at the Department of Health Science and Technology at ETH Zurich in Switzerland, who performs his thesis work on Ingber's team.

His symptoms may come closer to mimicking the human disease than most mouse models of mental illness, because the gene involved has such a powerful effect.

By tuning the model to replicate population data, such as the number of people at risk for developing TB and the fraction of TB patients who have drug resistance, the model can predict changes in the TB disease burden — or number of cases — over many years.

Several other components would be disbursed among the National Institute of General Medical Sciences (such as disease model resources), NIH's imaging institute, and its institute for minority health research.

That has implications for genetic models that predict how likely it is that members of a family will inherit a trait, whether it's a disease such as schizophrenia or a physical trait, such as height.

In a Philadelphia Inquirer op - ed, he wrote that such eternal life was in our reach because «Being able to decode the human genome allows us to develop detailed models of how major diseases, such as heart disease and cancer, progress, and gives us the tools to reprogram those processes away from disease.»

Such a language is a critical and essential element in addressing the ongoing challenge of developing more intricate and comprehensive models of Alzheimer's disease... for the identification of new interventions and diagnostics.»

The model offers the possibility of carrying out studies that might result in treatments to reverse or prevent diseases such as type 2 diabetes and obesity.»

Besides potentially upending the textbook model of DNA organization, the team's results suggest that controlling access to chromatin could be a useful approach to preventing, diagnosing and treating diseases such as cancer.

A new model for post-integration latency in macroglial cells to study HIV - 1 reservoirs of the brain, AIDS, DOI: 10.1097 / QAD.0000000000000691 Link to the original publication As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus and lung diseases.

Experimental animal models have been used to investigate many aspects of the clinical disease such as the sex bias in myocarditis where testosterones in males promote autoimmunity in the heart while estrogens in females suppress virus infection and autoimmunity.

«In the future, such detailed digital models of diseases and the structure of organs could be used to help diagnose conditions, understand the impact of surgical interventions and even run digital drug trials.

We postulate that HD mutant hPSC (embryonic or induced) lines can constitute such models and would be key to the exploration of the molecular mechanisms of the disease and ultimately allow the screening of therapeutic compounds endowed with a therapeutic potential.

«We are excited to be part of such a visionary initiative from the three leading ALS foundations to build a truly groundbreaking model to underpin the future of therapeutics discovery,» said Wen Hwa Lee, Ph.D., Director of Disease Foundations at the Structural Genomics Consortium and based at the University of Oxford.

Using this model, individuals and public health officials can monitor disease incidence and implement strategies — such as vaccination campaigns, communicating to the public and allocating resources — to stay one step ahead of infectious disease spread.

The objective is to support innovative projects dedicated to the development and the study of rare disease models using small animals (mouse model excepted) such as zebrafish, drosophila, nematode, rat and rabbit.

These in turn can be used for disease modeling and drug discovery, but hopefully one day also for cell - based therapy of the many devastating diseases such as Alzheimer and Parkinson's Ddisease modeling and drug discovery, but hopefully one day also for cell - based therapy of the many devastating diseases such as Alzheimer and Parkinson's DiseaseDisease.

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

We carry out translational research programmes to develop infectious disease vaccines, therapeutics and diagnostics using animal models of tuberculosis, influenza, HIV / AIDS, Clostridium difficile, meningococcal disease, chlamydia, burkholderia and anthrax, as well as emerging viral diseases such as Crimean Congo haemorrhagic fever.

Historically, researchers have generated their own lines of knockout mice to serve as models for human disease, such as heart disease or cancer.

Complementing its extensive capabilities, PsychoGenics offers a variety of validated mouse models including in - licensed transgenic models that support research in areas such as Alzheimer's disease, Huntington's disease, Parkinson's disease, Autism spectrum disorders, psychosis / schizophrenia, Spinal Muscular Atrophy (SMA), muscular dystrophy and other muscle disorders.

He uses the paradigm of nuclear hormone receptor activation / signaling and the contribution of this process to myeloid cell differentiation, function, and to diseases, involving these cells, such as atherosclerosis, tissue regeneration, metabolic, and various inflammatory disorders, as his model systems.