Sentences with phrase «models of disease through»

The CRISPR - Cas technology is used to generate more accurate genotypic models of disease through precise genomic changes.

Not exact matches

Neurologist Malcolm MacLeod of the Centre for Clinical Brain Sciences at the University of Edinburgh and his colleagues combed through papers reporting the efficacy of drugs in eight animal disease models and checked whether the authors reported four measures that are widely acknowledged to reduce the risk of bias.

Instead of systematically testing the effects of known compounds — the pharmaceutical industry's basic model for more than a century — scientists can now investigate backward, combing through genomic data to find links between specific genotypes and diseases and then screening drug data to identify therapeutic candidates.

Now Perry and Holmes have built up a detailed picture of how this happens through experiments in mice with prion disease, a model of neurodegeneration.

Written by 25 authors, it described the collaboration between government, academic researchers, and disease advocacy groups that led to the ICV trial as a model of the teamwork that can speed drugs through early development, boosting their chances of being commercialized.

One of the most promising avenues for developing a cure, however, is through gene therapy, and to create those therapies requires animal models of disease that closely replicate the human condition.

With the brain - on - a-chip platform, Kulp said researchers could analyze how disease spreads through the brain, model epilepsy, or potentially examine the effects of chemical or biological exposure over a timespan of several months.

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The construction of the University Technology Center is the next step to enabling Penn State College of Medicine to utilize «big data» to enhance patient care through disease modeling and predictors for disease by more efficiently processing and analyzing clinical information.

This makes a strong case for the utility of lineage through program cells for diseased modeling.

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Sergiu P. Pasca, 36, assistant professor of psychiatry and behavioral sciences at Stanford, uses models of the human brain — created through cellular reprogramming technology — to explore the biological underpinnings of brain diseases like autism.

«In a way, we're modeling one mechanism through which genes affect disease or traits, which is the regulation of gene expression level.»

In the fall of 2012, their group demonstrated that misfolded versions of α - synuclein, the protein implicated in Parkinson's disease, can be transmitted from cell to cell in mouse models, adding weight to a hypothesis that a common mechanism of neurodegenerative disorders could involve the passage of misfolded proteins through the central nervous system.

Each month through partnerships with researchers around the world, the MMRRC enhances critical research with a continuously expanding catalog of mouse models of human disease.

Through the use of animal models, researchers have sought to understand the etiology of post-treatment Lyme disease syndrome (PTLDS), namely whether or not the spirochetes persist post-treatment and could thus contribute to chronic symptoms.

The main goal of these technologies is to accelerate the comprehension of our genome and of human diseases, and to promote therapeutic innovation through the validation of molecular targets and their effects in reference model organisms.

The mouse phenogenomics is currently the key way through modelling of disease in biomedicine.

Emulate continues to develop a wide range of Organ - Chips and disease models through collaborations with industry partners and internal R&D programs.

Drugs that block signaling through this CRF receptor reduce brain damage and deficits in learning and memory in a mouse model of Alzheimer's, suggesting a new potential treatment for this devastating disease.

We aim to develop a system that links gene discovery to signaling pathways and eventually to set up animal models of disease by manipulating genes of interest through mouse genetics.

Will this use of higher mammals, modeled and modified through the marvels of CRISPR, lead to effective therapies for some of our most intractable diseases?

Chronic exposure to aluminum and melatonin through the diet: Neurobehavioral effects in a transgenic mouse model of Alzheimer disease Food Chem Toxicol.

This diet is not one to model after, «The data collected through this new investigation shows that Eskimos do have a similar prevalence of [coronary artery disease] CAD to non-Eskimo populations, and in fact, they have very high rates of mortality due to cerebrovascular events (strokes).

Some phytochemicals that have demonstrated protective effects in both tissue culture and animal models of Parkinson's and neurodegenerative disease through the Keap1 / Nrf2 / ARE pathway include:

The emphasis is on developing intellectual abilities and research skills through investigations of infectious diseases of food - producing, companion, and aquatic animals, as well as animal models for human disease.

J. Lidicker MA et al, Lyme Disease Cases in the United States Projected Through 2012: Time Series Model Identification and Forecasts of the Federal CDC Data.