Sentences with phrase «models of human physiology»

Not exact matches

In 1859, Charles Darwin's evolutionary theory reinforced the conception that animals could serve as models for humans in the study of biology and physiology.

The advance, reported in Proceedings of the National Academy of Sciences (PNAS) journal, for the first time allows scientists to analyze how normal gut microbes and pathogenic bacteria contribute to immune responses, and to investigate IBD mechanisms in a controlled model that recapitulates human intestinal physiology.

«In our human airway epithelial model system, one of the drugs destabilizes and deactivates the protein that the other drug tries to correct,» said Martina Gentzsch, PhD, an assistant professor of cell biology and physiology and senior author of the UNC Science Translational Medicine paper.

«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.

It is being instituted as a routine service for research means that all researchers now have the capability to more closely relate research model findings to human health and physiology,» said Jose Barrera, director of the Shimadzu Institute and a co-author on the new paper published by the journal Analytica Chimica Acta.

Eran Andrechek, a physiology professor in the College of Human Medicine at Michigan State University, has discovered that many of the various models used in breast cancer research can replicate several characteristics of the human disease, especially at the gene lHuman Medicine at Michigan State University, has discovered that many of the various models used in breast cancer research can replicate several characteristics of the human disease, especially at the gene lhuman disease, especially at the gene level.

Models using human tissues, reproducing key features of biochemistry and physiology, have enormous potential in brain research.

Professor Segal's research has two major directions 1) Gene regulation — using quantitative and computational models to understand how DNA sequence variation among human individuals generates phenotypic diversity 2) Microbiome and Nutrition — understanding how the microbial composition of individuals affect their physiology and health.

Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

adapt computer hardware or software for medical science or health care applications (for example, develop expert systems that assist in diagnosing diseases, medical imaging systems, models of different aspects of human physiology or medical data management)

THE MOUSE MODEL FOR CYSTIC FIBROSIS, as with models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his work.

Meanwhile, CRISPR also makes it easier to edit the genomes of relatively large animals, whose metabolism, physiology and anatomy are closer to humans than previous models have been.

«We hope our human model of ALS will help us to move quickly and effectively to identify promising therapeutic candidates for ALS,» said Gladstone Senior Investigator Steve Finkbeiner, MD, PhD, who is also a professor of neurology and physiology at the University of California, San Francisco, with which Gladstone is affiliated.

The story was based on a paper presented by Steven Sherwood of the University of New South Wales, who adds human physiology into the climate models to suggest that «physiological limits of the human body will begin to render places impossible to support human life if the average global temperature rises by 7C on pre-industrial levels».

The course will include discussion about the unique difficulties of doing sex therapy for the therapist - The definition of female and male sexual dysfunctions - The physiology of the human sexual response - The models of sexual behaviors - How to diagnose and evaluate if the couple does actually present with a primary sexual dysfunction or the dysfunction is a symptom of a deteriorated relationship that has to be addressed before sex therapy is started.