Several researchers found a greater effect for those who are suffering from mild to
moderate depression rather than intermittent bouts of depressive symptoms or more severe depression (Celano et al., 2016)
Not exact matches
According to reviews of the role of the 5 - HTTLPR in
moderating the effects of stress upon
depression, the effect is most reproducible when objective measures of stress are used (Uher and McGuffin, 2010),
rather than subjective measures, for which the interaction has not universally replicated (Risch et al., 2009).
It may be reasonable therefore to apply these results to patients with alcoholism who have
moderate,
rather than severe,
depression after detoxification and washout.
Age did not significantly
moderate this relationship, which could suggest that the emergence of the gender difference in
depression rates is caused by puberty - related,
rather than age - related changes.