Sentences with phrase «modes of action for»

Dr. Peter Infante, a former director of the Office of Carcinogen Identification and Classification at the Occupational Safety and Health Administration, called the NAS critique «arrogant» because «we don't know the mode of action for most things that cause cancer.»

«New mode of action for HUMIRA in rheumatoid arthritis patients.»

AcCoA complex reveals an additional mode of action for the antimetabolite N - pentyl pantothenamide (N5 - Pan) is published in Biochemistry.

Not exact matches

Liz Vaccariello, author of The Digest Diet, explains how you can lose weight fast by eating foods you already shop for, as certain foods, actions, and activities can gently shift your body into fat release mode.

They say then that it is more simple to believe at once in the eternal pre-existence of the world, as it is now going on, and may for ever go on by the principle of reproduction which we see and witness, than to believe in the eternal pre-existence of an ulterior cause, or Creator of the world, a being whom we see not, and know not, of whose form substance and mode or place of existence, or of action no sense informs us, no power of the mind enables us to delineate or comprehend.

Science and metaphysics too, providing the latter is viewed as a natural mode of cognition and is not unconsciously supplemented by theological knowledge about God's saving action in the history of redemption, can each from their own angle quite well think of God as the transcendent ground of all reality, of its existence and of its becoming, as the primordial reality comprising everything, supporting everything, but precisely for that reason can not regard him as a partial factor and component in the reality with which we are confronted, nor as a member of its causal series.

... even if, like Germany's Gerhard Schröder, German Chancellor from 1998 - 2005, you are of the general social democrat mode, you rely on centralized government action too much, and you are not above stoking rabid denunciation of U.S. efforts to fight terrorism and WMD proliferation for your own political gain.

... even if, like Germany's Gerhard Schröder, German Chancellor from 1998 - 2005, you are of the general social democrat mode, you rely on centralized government action too much, and you are not above stoking rabid denunciation of U.S. efforts to fight terrorism and WMD proliferation for....

Functioning on the basis of the principle that «the how of our present experience must conform to the what of the past in us» (S 58), symbolic reference operates in the intersection of the two modes of perception, an intersection at which «a pair of such percepts must have elements of structure in common, whereby they are marked out for the action of symbolic reference» (S 49).

For the Jaina, the task was that of real purification, requiring definite modes of action and abstinence from action.

Granted, there is room for considerable disagreement about the Christianly appropriate mode of this action.

But in her motion challenging the EFCC's ex parte application, Mrs. Jonathan, through her lawyers, argued that the EFCC's «Ex parte Originating Summons» was not one of the modes of commencement of action under Order 3, Rule 1 of the Federal High Court (Civil Procedure Rules) 2009, and that it was not known or provided for by any law or rules of court.

To get the most efficient cuts out of this jigsaw, you will also want to choose the appropriate orbital action mode for the material you are working with.

«We were looking for agents that display a mode of action very different from those of current antibiotics,» said Nibbering.

Now, for the first time the JMU scientists crystallized an antibody effective against Sclerostin and analysed its mode of action in detail.

«Mensacarcin's unique mode of action indicates it might represent a promising lead for the development of new anticancer drugs.»

«Its unique mode of action suggests it may be a useful probe for examining energy metabolism,» she added.

Model for two distinct modes of Sox9 action in cartilage formation proposed in the present study.

Once in stampede mode, their actions can be predicted by taking into account particle interactions like repulsion and friction, says Dirk Helbing, a physicist at the Institute for Transport and Economics at Dresden University of Technology in Germany.

This is a new mode of action and might be a starting point for novel tuberculosis therapies.

«We anticipate a similar mode of action may operate in other organisms because similar RNAs have been found for clock genes in mice.

After obtaining his Ph.D. in June 2008 — and winning his university's prize for the best dissertation in natural sciences — Gebauer stayed at the Max Planck Institute of Colloids and Interfaces for 6 months, working with Markus Antonietti, the institute's director, exploring the mode of action of common antiscalants using his quantitative setup.

By studying the mode of action of the interleukin - 33 protein, an alarmin for white blood cells, a team at the Institut de Pharmacologie et de Biologie Structurale (IPBS — CNRS / Université Toulouse III — Paul Sabatier) has been able to evidence truncated forms of the protein that act as potent activators of the cells responsible for triggering allergic reactions.

The next step for the researchers will be to decipher the mode of action of the 100 new chromatin factors.

Stahlberg's team has now, however, found indications for another mode of action.

The precise understanding of the mode of action is thus the basis for developing specific drugs for the treatment of epilepsy and cardiac arrhythmias.

This indicates that the innovation potential has been substantial for fungicides with new modes of action and excellent performance, not least because some of the older groups have suffered from an erosion of efficacy against some important pathogens due to the emergence of resistance [see also FRAC 2007 (1)-RSB-.

In an interdisciplinary approach, the team will first systematically identify genes that are required for this differentiation process - information which will then be used to investigate their molecular mode of action, their targets, and if and how they interact with each other.

In conclusion, anthelminthics poorly fulfill the preconditions of a specific mode of anticancer action and availability of pharmacokinetic and pharmacodynamic data for a favorable repurposing as anticancer drugs.

In order to prioritize these hits compounds for the development of probe or lead molecules it is critical to determine their mode of action, i.e. the biological target protein.

The comprehensive information presented for each cell therapy includes: an overview of the therapy, a list of therapeutic cells utilized in the specific treatment, mode and regimen of cell delivery, mechanism of action, formulation, in vitro data, animal models, preclinical data and related clinical trials.

He gave a similarly negative reply to a question about the use of the vaccine in patients undergoing deep brain stimulation (DBS) for PD, «given the mode of action of disease modifiers,» because DBS is typically reserved to patients in relatively advanced stages of the disease.

The first signal of pain would send glial sends into an alert mode, preparing them for more action.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Features, such as fast parasite killing, good safety margin, a potentially novel mode of action and a distinct chemotype support the clinical development of SC83288, as an intravenous application for the treatment of severe malaria.

Ultimately, while much remains to be known about IER, its modes of actions and long - term efficacy, the positive findings to date serve to highlight promising avenues for future research.

The mode of action may lie in the fact that there are omega - 3 receptors on the channels for potassium in the blood vessels, allowing the flow of potassium, which lowers blood pressure (18, 19).

Finally, while the most obvious solution to metabolic endotoxinemia appears to be to reduce saturated fat intake, the Western diet is not conducive to this mode of action, and it is difficult for patients to comply with this request»

First springtime mode of action: trade in your bulky sweaters for bright, flirty sundresses!

You can make use of the 3 chat modes which includes instant messenger, flash chat and chat rooms for live actions.

It shows human beings in all their pitiable, noble, stupid or sensitive modes of action, and it reminds us there's always time to fall in love, if only for a few days.

The fast paced gameplay mixed with the abundance of online modes make this easily recommendable for any fans of hardcore shooting action.

For all the cinematic dreck currently peddling disorienting editing as «action,» no one in good conscience could deride Tarantino for his indulgence in split screens or extreme close ups or smash zooms or any other mode of cinematic gimmickry, when it affords us hauntingly sparse centerpieces such as The Bride's live burial, an aural choir of oppressive dirt, panting whimpers, and futile struggling set to the visual accompaniment of pitch black confinement that stretches on well past any spectator's comfort levFor all the cinematic dreck currently peddling disorienting editing as «action,» no one in good conscience could deride Tarantino for his indulgence in split screens or extreme close ups or smash zooms or any other mode of cinematic gimmickry, when it affords us hauntingly sparse centerpieces such as The Bride's live burial, an aural choir of oppressive dirt, panting whimpers, and futile struggling set to the visual accompaniment of pitch black confinement that stretches on well past any spectator's comfort levfor his indulgence in split screens or extreme close ups or smash zooms or any other mode of cinematic gimmickry, when it affords us hauntingly sparse centerpieces such as The Bride's live burial, an aural choir of oppressive dirt, panting whimpers, and futile struggling set to the visual accompaniment of pitch black confinement that stretches on well past any spectator's comfort level.

When you want to play an epic, meaty game like Super Mario Odyssey or Breath of the Wild, the dock is waiting for some big screen action, but when you want a quick burst of fun, games like Puzzle Adventure Blockle and Kamiko are there to keep you company in handheld mode.

As well as being copiously stuffed with a ridiculous number of mind - twisting puzzles, the Switch version features touchscreen controls for maximum intense finger action in handheld mode.

Vehicle Tag — Once you're done taking down the Freaks and the Cell, join your friends for a new multiplayer mode where up to eight Agents can compete in these six arenas: Speed is the Quay, Industrial Action, Maim Street, Skid Row, Beachhead and The Sum of Human Knowledge.

The 3DS version of Super Smash Bros. offers a ton of single player content, an improved online mode, and plenty of multi-player options with non-stop fighting action to keep you coming back for more.

The 3DS version of Super Smash Bros. offers a ton of single player content, an improved online mode, and plenty of multiplayer options with non-stop fighting action to keep you coming back for more.

Unlike the Naruto: Ultimate Ninja Storm series which is more and more a mess of technical, balance and gameplay issues these days, Brave Soldiers delivers what is a nice, franchise - based fighting game, at first, i was expecting a simple fighting game with some button mashing, however, the game proved me wrong and i fell in love, the combo system, while easy, is a lot more deep than the one in the Naruto games, with all of the characters having two special attacks, two «burst attacks», a knock - away and a launcher respectively, a throw and an ultimate attack (called a «Big Bang Attack»), every character also has an universal dodge - action that sends them behind their enemies while spending one cosmo bar, making bar management that much precious and shielding you from a half - a-hour combo, unlike in the NUNS series, the fighting and the characters are nicely balanced, with every character being fun to play and viable at the same time, the game runs smoothly without frame - rate issues and the cell - shaded graphics, character models, arenas and effects alike are nice to the eye, battles are divided into rounds, with all the tiny nice stuff like character introductions and outros being intact (fun fact: the characters will even comment on their score after the battle), the game also features an awakening system, called the «Seventh Sense» awakening, unlike the NUNS awakening system which became severely unbalanced in the later game, every character simply gains a damage / defense boost, with the conditions being the same for all characters, eliminating situations when one character can use awakening at almost any point in the battle, or one awakening being drastically stronger than the other, the game has a story mode with three story arcs used to unlock characters, a collection mode, tournament modes, a survival mode, a series of special versus modes and online battle modes.

However, the «Performance» mode drops the resolution down to 720p and boosts the framerate to 60 fps (needless to say this only applies to docked mode); whether or not this is an acceptable trade - off for you is all down to personal taste, but the smoothness of the action really does make a difference, and we opted to play in Performance during the whole adventure.