Sentences with phrase «modification of human cells»

«Germline editing» — genetic modification of human cells, including embryos, eggs and sperm, that can be passed to future generations — has been controversial.

Not exact matches

Therefore, it is essential that we learn how specific types of chemical modifications normally regulate RNA function in our cells, in order to understand how dysregulation of this process contributes to human disease, says Cristian Bellodi.

Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant cells, «our discoveries pave the way for future avenues of research aimed at exploring the role of pseudouridine in human development disease,» concludes Cristian Bellodi.

Dr. Bellodi's laboratory uncovered a new important function of pseudouridine, the most common type of RNA modification in human cells.

Researchers in optogenetics can control genetically modified brain cells using light but because of these modifications, the technique is not yet deemed safe to use in humans.

The researchers have shown that it is possible to produce chromosome modifications in human cells that are genetically identical to those observed in leukemia and other types of human cancer.

In the human body cells turn genes on and off by means of chemical modifications that change DNA and related proteins.

That paper, which tried to correct a mutation that causes a blood disease, fed into a firestorm over the ethics of modifying human reproductive cells (or «germline» modification).

In the Nature papers, the researchers compared gene transcription, chromatin modification and other processes that control gene activity in a wide range of mouse and human tissues and cell types.

«While genetic modification of crops can introduce new beneficial traits into existing crops, the resulting products need to be tested for long - term health effects before making assumptions about their impact on human health,» said senior investigator Frances Sladek, a professor of cell biology and neuroscience at UC Riverside.

Marson stressed that, while recent reports of CRISPR / Cas9 editing of human embryos have stirred up controversy, T cells are created anew in each individual, so modifications would not be passed on to future generations.

The NIH Roadmap Epigenomics Consortium has just published the largest collection of epigenomes characterized to date: 111 primary human tissues and cells profiled for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

One of my favorite papers from this year was the landmark publication of the NIH Epigenomics Roadmap Consortium, which profiled 111 primary human tissues and cell types for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

Now, in Stem Cells Translation Medicine, the group of Shu Wang at the National University of Singapore describe the derivation of EPCs from human iPSCs, their therapeutic modification, and their ability to inhibit tumor growth in a mouse breast cancer model [4].

Modification of human embryonic stem cell - derived dendritic cells with mRNA for efficient antigen presentation and enhanced potency.

The molecules central to this balancing act, H3K4me3 and H3K27me3, are among the so - called epigenetic modifications that influence the activity patterns of genes in both human embryonic stem (ES) cells and mature human adult cells.

A human embryonic stem cell is reined in — prevented from giving up its unique characteristics of self - renewal and pluripotency — by the presence of a protein modification that stifles any genes that would prematurely instruct the cell to develop into heart or other specialized tissue.

While many important developments impacted the field, two that garnered significant public, political and scientific attention in 2016 were the proliferation of clinics using unproven stem cell «therapies,» and the steps forward in therapeutic modification of human oocytes (unfertilized eggs) through a process called mitochondrial replacement therapy (MRT).

Dr. Vijayanand also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

Publication in Molecular Cell on reversal of base modifications in messenger RNA (mRNA) and role in human disease

The quality and novelty of the data, leads to new insights into the replication landscape of the human genome and to further unravel the links between replication, gene expression, epigenetic modification and 3D genome organization in normal and cancer cells.

Vijay also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

«Before our technique, genetic modification of human embryonic stem cells largely was inefficient,» Hohenstein said.

[PRESS RELEASE 2017-05-05] A new study in Science from Karolinska Institutet maps out how different DNA - binding proteins in human cells react to certain biochemical modifications of the DNA molecule.

Dissertation: «Epigenetic Modification of Vitamin D - induced Gene Expression in Human Colorectal and Breast Cancer Cell Lines.»

Keiichiro Suzuki, a CRISPR expert from Salk Institute researcher, also not involved in the study, said by email: «Due to the high stability, specificity and ease for biosynthesis, the synthetic CRISPR RNA approach developed in this study will facilitate targeted genetic modification in a variety of human cells for fundamental studies as well as therapeutic applications»

Epidemiological evidence and intervention studies clearly show that in humans saturated fat significantly worsen insulin - resistance, while monounsaturated and polyunsaturated fatty acids improve it through modifications in the composition of cell membranes which reflect at least in part dietary fat composition.

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