Sentences with phrase «modified nucleoside»

It hasn't revealed which modified nucleoside is in its newest generation of drug candidates.

The team knew that the frequency and placement of the modified nucleosides in the strand changed how it folded, and hence how it interacted with the ribosome.

Initially operating in «stealth mode» — without announcement of its existence — Moderna's team screened mRNA assembled from various modified nucleosides and hit on one called 1 - methylpseudouridine.

Even between mRNAs with the same sequence, they were finding that different modified nucleosides produced different amounts of protein.

Mass - spectrometry - based methods have been at the forefront of identifying and quantifying modified nucleosides.

However, they often require synthetic reference standards, which do not exist in the case of many modified nucleosides, and this therefore impedes their analysis.

Not exact matches

«It would be stupendous to see the data out of Moderna,» says Paul Agris, an analytical biochemist at the State University of New York in Albany's RNA Institute who has spent decades studying the consequences of modifying RNA nucleosides.

However, very early I discovered that this was not the case and later on I found out that cells are not ready to recycle these modified forms of nucleosides.