It is a way to
modify cells in the immune system.
Not exact matches
In this approach,
immune cells are removed from a patient, genetically
modified or treated with chemicals to enhance their activity, and then re-introduced into the patient with the goal of improving the
immune system's anti-cancer response.
Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor
cells irradiated and genetically
modified to produce
immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity
in multiple mouse tumor models.
Our chemically
modified siRNA molecules, designed to retain stability
in the bloodstream without stimulating the
immune system, are able to target certain kidney
cells without the need for a delivery
system when given intravenously.
In this approach, T
cells are removed from a patient, genetically
modified or treated with chemicals to enhance their activity, and then re-introduced into the patient with the goal of improving the T
cell immune system's anti-cancer response.
In this approach, T
cells are removed from a patient, genetically
modified or treated with chemicals to enhance their activity, and then re-introduced into the patient with the goal of improving the
immune system's anti-cancer response.
In this approach, T
cells are removed from a patient, genetically
modified or treated with chemicals to enhance their activity or numbers, and then re-introduced into the patient with the goal of improving the
immune system's anti-cancer response.
They then injected the edited human
cells into seven mice with compromised
immune systems to see if the
modified cells would take hold — a step that would be necessary if the same procedure were to be done
in humans.
The Joslin researchers then transplanted these
modified human diabetic
cells into wounds
in mice models of diabetes that also had suppressed
immune systems so that they didn't reject human
cells.
Special Areas of Interest: Osteosarcoma, plasma
cell tumors, lymphoma, mast
cell tumors, and investigating ways
in which the
immune system can be
modified to better recognize and eliminate cancer
cells.