In the future, scientists may be able to
modify human stem cell lines in the laboratory by using gene therapy or other techniques to overcome this immune rejection.
Church is already adapting MAGE for genetically
modifying human stem cell lines.
Muscles from mice treated with
modified human stem cells show human dystrophin - producing muscle fibers (yellow) integrated among mouse muscle fibers (red).
51) Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J.E., van Wezel, T., Nik - Zainal, S., Kuiper, R.P., Cuppen, E., and Clevers, H. Use of CRISPR -
modified human stem cell organoids to study the origin of mutational signatures in cancer.
Not exact matches
The laboratory process, described in the journal Scientific Reports, entails genetically
modifying a line of
human embryonic
stem cells to become fluorescent upon their differentiation to retinal ganglion cells, and then using that cell line for development of new differentiation methods and characterization of the resulting cells.
In a commentary accompanying the new study, Dolly cloner Ian Wilmut and his co-worker Jane Taylor of the University of Edinburgh in Scotland wrote that «a
modified approach to direct reprogramming... is likely to be the ultimate method of choice for producing
human stem cells.»
Beilhack and colleagues found that a slightly
modified version of STAR2 has a similar effect on
human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic
stem cell transplants.
While the
human stem cells derived through conventional methods failed to integrate into the
modified embryos, the
human rsPSCs began to develop into early stage tissues.
Lentiviral - based gene therapy methods to
modify human CD34 + hematopoietic
stem cells have been investigated as a way of treating various hematological disorders including X-linked chronic granulomatous disease (X-CGD).
Kucherlapati: Without thinking about
modifying the
human genome line, would this technology have the ability to affect the health of
humans by
modifying the
stem cells?
Not only could
modifying the subject matter attract more diversity to
STEM, it could also help ensure that future technologies are more empathetic to a wider range of
human needs.
However welcome the recent announcement that a team of scientists based at Newcastle University, has grown a section of
human liver using
stem cells from umbilical cords, rather than from the more controversial source of embryonic
stem cells, and whatever the eventual promise or potential of harvesting organs for transplantation from genetically
modified pigs, the benefits of either of these two pioneering techniques to currently dying / suffering patients, remain both elusive and distant.