This enables scientists to genetically
modify phage genomes systematically, provide them with additional functionality, and finally reactivate them in a bacterial «surrogate» — a cell - wall deficient Listeria cell, or L - form.
Isolating
the modified phage was therefore often like searching for a needle in a haystack.
Not exact matches
With the use of careful
phage isolation procedures and environmental samples from various locations, such as alternative media usage and
modified plaque - picking methods, we isolated potentially novel
phages.