AMD3100, alone or in combination with VIC - 008, decreases expression of the
immune checkpoint molecule PD - 1 on CD8 T cells, implying that the CXCR4 / CXCR12 pathway
modulates PD - 1 expression.
PEGylated arginine deiminase can
modulate tumor
immune microenvironment by affecting
immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration.