Sentences with phrase «modulates cytokine production»

CRAC channels control the entry of calcium into immune and other cell types, and calcium is an important intracellular signaling molecule that modulates cytokine production and the immune response.

Not exact matches

(2005) Pressure - Induced Production of Inflammatory Cytokines and Activation of NF B Is Modulated by Calcium Channels in Retinal Glia (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 3579).

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

Thus, a series of studies have shown that marital conflict alters physiological functioning, and hostile behavior, particularly during conflict, markedly enhances adverse physiological changes; moreover, women appear to be more adversely affected than men.5 In this study, we extended this line of research to assess how hostile marital behavior modulated an important health outcome, wound healing, as well as local and systemic proinflammatory cytokine production.

Objective To assess how hostile marital behaviors modulate wound healing, as well as local and systemic proinflammatory cytokine production.