In 2000, researcher Alessio Fasano and his team discovered zonulin, a protein that
modulates tight junction integrity (6).
Not exact matches
A protein called zonulin is responsible for induction of tolerance and orchestration of immune responses by
modulating intercellular
tight junctions in the gastrointestinal epithelium in a rapid, reversible, and reproducible fashion (Fasano, 2011).
Tight junctions, regulated by a molecule called zonulin, as well as by conformational changes in the proteins occludin and claudin, are dynamic intercellular structures that
modulate the trafficking or passage of macromolecules from the intestinal lumen to the submucosa and into systemic circulation (Fasano, 2012).