Sentences with phrase «molecular and cellular mechanisms»

Vascular Calcification Insights into vascular biology from rare disease Cynthia St. Hillaire, University of Pittsburgh Biomechanical regulation of fibrocalcific aortic valve disease Craig Simmons, University of Toronto Molecular and cellular mechanisms of aortic valve remodeling Katherine E. Yutzey, Cincinnati Children's Medical Center

Main interest of the Unit is to unravel the key molecular and cellular mechanisms controlling immune tolerance, responsible for maintaining tissue homeostasis and avoiding adverse immune responses.

This tenet links and integrates basic molecular and cellular mechanisms in an organism with cognitive motivations and psychology.

The critical molecular and cellular mechanisms that the T cells use to sense their environment and how this sensing is relayed into a particular functional response are still unclear.

Penetration of a male copulatory organ into a suitable mate is a conserved and necessary behavioral step for most terrestrial matings; however, the detailed molecular and cellular mechanisms for this

Targets of research range from basic molecular and cellular mechanisms, the manipulation of these mechanisms in animal models, analyses of the genes and gene products in cardiovascular disease, and clinical research that seeks to improve diagnosis and therapy for patients.

After this experience, I felt the itch to look deeper into the molecular and cellular mechanisms of behavior.

«We reasoned that if we could identify microRNAs that regulate the progression of colorectal cancer, we could use them as molecular probes to better understand the molecular and cellular mechanisms that govern liver colonization,» says Tavazoie, who is Leon Hess Associate Professor and head of the Elizabeth and Vincent Meyer Laboratory of Systems Cancer Biology.

Yet the molecular and cellular mechanisms that underlie these problems are still only partly understood.

In addition, it provides a marker for cell fates and insight into the molecular and cellular mechanisms by which FSC progeny diverge into distinct fates.

Future studies should elucidate the molecular and cellular mechanisms by which regional environment controls phenotypic variations of neuronal types.

But the new findings «are the first clear evidence for a molecular and cellular mechanism of synaptic loss in schizophrenia,» said Jonathan Sebat, chief of the Beyster Center for Molecular Genomics of Neuropsychiatric Diseases at the University of California, San Diego, who was not involved in the study.

Future studies on the molecular and cellular mechanisms of chandelier cell wiring will uncover important insights into how inhibitory circuits are assembled during development.

«Almost nothing is known» about the molecular and cellular mechanism by which water is detected in the mouth and throat, and the neural pathway by which that signal is transmitted to the brain, says Zachary Knight, a neuroscientist at the University of California, San Francisco.

A previous study by Segev at the laboratory for research of molecular and cellular mechanisms, directed by Prof. Kobi Rosenblum in the Sagol Department of Neurobiology at the University of Haifa, found a connection between a genetic condition known to be a risk factor for sporadic Alzheimer's and premature aging as manifested in ongoing metabolic stress.

Dr. Maria Iribarne, first author of this study, commented: «The gosh mutant is a good model for understanding the molecular and cellular mechanism of cone cell death and the pathological process of human LCA.

Such effects alone could explain why memory seems to falter with age, without there being any weakening of the molecular and cellular mechanisms of memory itself.

What are the molecular and cellular mechanisms by which patients with certain chronic diseases have increased or decreased risks for developing cancer, and can these connections be exploited to develop novel preventive or therapeutic strategies?

Dr. Sonntag's scientific interest is to understand the molecular and cellular mechanisms and factors governing neuronal function and dysfunction in the aging brain and in neurodegenerative or neurological disorders.

Our goal is to characterize some of the molecular and cellular mechanisms involved in the local regulation of the energy metabolism in the axon during the embryonic and postnatal development, and to understand the consequences of disrupting the energy metabolism of developing neurons on axon development and circuit formation in the mouse.

Research in our laboratory focuses on the biological and pathophysiological functions of apolipoprotein (apo) E. Long - term goals of our research are to understand the molecular and cellular mechanisms by which apoE4 increases the risk of Alzheimer's disease (AD) and related neurodegeneratative disorders and to develop therapeutic strategies to treat or prevent AD.

At Weizmann, Dr. Spiegel will be establishing his own independent research group which will attempt to identify the molecular and cellular mechanisms through which experience alters the structure and function of neural circuits in the brain in behaviorally relevant ways and to understand how these processes, when they go awry, might give rise to psychiatric disorders.

«Our findings both validate and prompt further use of this first - in - kind fly model of kidney cyst formation in order to pinpoint the molecular and cellular mechanisms at work,» says Gamberi.

In recent years, our laboratory has focused much effort on understanding the molecular and cellular mechanisms regulating muscle cell fusion.

She is interested in the molecular and cellular mechanisms that regulate stem cells in the adult brain.

Dr. Mucke has spent most of his career uncovering the molecular and cellular mechanisms that cause memory loss and behavioral abnormalities in Alzheimer's disease and related conditions.

Yusuke did his graduate work in Dr Yukiko Gotoh lab at University of Tokyo and joined the Polleux lab in 2013 where he studies the molecular and cellular mechanisms underlying presynaptic capture of mitochondria.

In addition to ADA - SCID and WAS, the research group is currently investigating the molecular and cellular mechanisms linked to mutations in genes encoding the gp91phox NADPH oxidase (Chronic Granulomatous Disease), ARPC1B and ADA2 / CECR1 with the final goal to develop a gene therapy approach for these diseases.

While mouse has been successfully used to study multiple aspects of kidney development, the amphibian pronephros of Xenopus offers a valuable alternative to explore the underlying molecular and cellular mechanisms.

She continued to develop these models and to investigate the molecular and cellular mechanisms underlying human tumor dormancy as an instructor in Folkman's lab and later as an Assistant Professor at the Center of Cancer Systems Biology at Tufts University School of Medicine, Boston.

Most of the discussion section at the end of the paper focuses on the complexity of the molecular and cellular mechanisms involved with vascular injury, especially in very advanced lesions.

She is studying the molecular and cellular mechanisms that control the development and homeostasis of medullary thymic epithelial cell, key actors in T - cell tolerance induction.

We examine the molecular and cellular mechanisms through which androgens and estrogens, as well as the neuropeptide vasotocin, affect behavioral and brain responses to sensory cues that elicit different types of social output, from courtship to aggression to withdrawal.

However, the molecular and cellular mechanisms controlling interactions within the metaorganisms are poorly understood and many key interactions between the associated organisms remain unknown.