Understanding
the molecular basis of aging is critical to finding new methods for prevention and treatment of age -... >> MORE
After the funding for Eurage expired, Clark, Knook, Franceschi, and other colleagues won a grant from the European Commission (E.C.)-- the executive branch of the newly formed European Union — to support Molgeron, a network of 12 European research labs that were studying
the molecular basis of aging.
Not exact matches
Dr. Martin Dohrmann and Professor Gert Wörheide
of the Division
of Palaeontology and Geobiology in the Department
of Earth and Environmental Sciences at Ludwig - Maximilians - Universitaet (LMU) in Munich have now used a new strategy
based on the so - called
molecular - clock to investigate the chronology
of early animal evolution and produce a new estimate for the
ages of the oldest animal groups.
My laboratory aims to understand the
molecular and cellular
basis of aging in mammals.»
This is as you'd predict,
based on the principle
of the «weakest link in the chain»: to move the needle on maximum lifespan, you have to push back on all
of the cellular and
molecular damage
of aging, not just one form.
While the benefits
of calorie restriction (CR — reducing food provisions relative to ad libitum, «free choice» consumption) for metabolic /
aging - related disease prevention and longevity promotion are well documented in multiple organisms, the
molecular basis for these benefits is still debated... >> MORE
Regulatory reform will be necessary to adopt a system
based on treating existing pathology to one
based on repair
of the cellular and
molecular damage that causes it, with the outcome being the delay and eventual indefinite postponement
of the very onset
of such pathology with
age.
With his Pioneer Award, Ismagilov will develop droplet -
based microfluidic technologies for quantitative studies
of protein aggregation diseases and
aging at the
molecular level and in entire organisms.
I now propose to tackle the new problem
of the
molecular basis of skeletal muscle fatigue, particularly as it relates to loss
of muscle function with
aging.
Aging is characterized by progressive loss
of physiological and cellular functions, but the
molecular basis of this decline remains unclear.
Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the
molecular basis of which is largely unknown.