Sentences with phrase «molecular causes of disease»

We now have an excellent model for this childhood disorder to learn about the molecular causes of disease and to test for potential therapeutic strategies.

Identifying the molecular causes of disease represented a major breakthrough in the history of medicine, moving the discipline from pattern recognition and therapeutic strategies based on syndromic pathophysiology to molecular mechanism and evidence ‐ based therapies derived from clinical trials designed on the basis of molecular mechanism.

Not exact matches

The notion that antisense oligonucleotides might inhibit the progression of genetic diseases or tumor - causing viruses dates back to the late 1970s, when legendary molecular biologist Paul Zamecnik and colleague Mary Stephenson demonstrated the method's viability against the Rous sarcoma virus.

These studies helped illuminate some of the molecular mechanisms by which these fungal pathogens cause disease in the banana.

«I do think the science is becoming mature enough that we are starting to understand really at a molecular level how a lot of these diseases are caused,» Fontoura said.

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

The team identified 345 regions of the genome where they could pinpoint the likely molecular causes underlying a person's predisposition to immune - related diseases such as inflammatory bowel disease, type 1 diabetes and multiple sclerosis.

«We found that a particular vaginal bacterium, Gardnerella vaginalis, did not cause infection during exposure to the urinary tract, but it damaged the cells on the surface of the bladder and caused E. coli from a previous UTI to start multiplying, leading to another bout of disease,» said the study's senior author, Amanda Lewis, PhD, an assistant professor of molecular microbiology and of obstetrics and gynecology at Washington University.

Mooney added, «Understanding and characterizing potentially functional HD protein interactions gives scientists new tools to connect genomic, genetic, proteomic and other molecular changes to identify the causes of this deadly disease.

Detection and molecular characterization of Ebola viruses causing disease in human and nonhuman primates

This can result in a serious genetic disease that can cause anemia, neuro - cognitive impairment, and even early death,» says the study's lead - author, Dr. Jean - Louis Guéant, director of the Inserm unit of Nutrition - Genetics - Environmental Risks at University of Lorraine and head of the Department of Molecular Medicine and Personalized Therapeutics — National Center of Inborn Errors of Metabolism at the University Regional Hospital of Nancy.

«Clearly, there are basic molecular mechanisms of aging that cause the various diseases that disable and ultimately kill us.»

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

The first clue to the importance of this molecular mimicry in herpes stromal keratitis (HSK), an autoimmune disease of the eye caused by infection with herpes virus 1 (HSV - 1), came about 3 years ago.

«Gastrointestinal diseases are a major cause of mortality in wild and captive pandas but scientists understand very little about their digestive process,» says co-author Ashli Brown Johnson, state chemist and Mississippi State University associate professor of biochemistry, molecular biology, entomology and plant pathology.

While researching the molecular causes of heart failure and new ways to treat it, a Charité - based working group, led by Prof. Dr. Ulrich Kintscher, found that changes in adipose (fat) tissue lipid metabolism affect disease development.

The researchers are investigating other mutations identified through the genetic screen and plan to undertake more genetic analysis of HLHS patients to better understand the molecular and genetic factors that cause the disease.

Bloomfield said updating the ELN recommendations was prompted by new insights into the molecular and genomic causes of the disease, by the development of new genetic tests and tests for detecting minimal residual disease and by the development of novel anti-leukemic agents.

Understanding its molecular causes and risk factors has been challenging because most cases develop sporadically without inherited genetic mutations, and because of the gradual progression of symptoms over the course of disease.

Scientists at the Max Planck Institute for Molecular Genetics in Berlin have found seven new genes that can cause this genetic disease: Mutations of these genes on the X chromosome lead to various forms of intellectual disability.

While the disease is caused by a single gene mutation, the manifestation of the disease at a molecular level is nevertheless highly complex and involves multiple cellular processes.

Published online ahead of print in the leading microbiology journal Molecular Microbiology, the researchers have identified a building block common to many types of bacterial «virulence factors» (the bacterial proteins which act as weapons to cause disease, such as toxins or degrading enzymes).

In the scientific article «Histone mutations separate R loops from genome instability induction» published in Molecular Cell, the researchers state that RNA joins with DNA by chance or because of a disease, the structure of the chromatin, the protein envelope of the chromosomes is altered, causing breaks in the DNA.

With the successful demonstration of the MRI probe, Northwestern researchers now have established the molecular basis for the cause, detection by non-invasive MR imaging and treatment of Alzheimer's disease.

Using this approach, these investigators found that nodes (genes) with high connectivity tend to have lower levels of change in expression than peripheral nodes, consistent with the notion that disease ‐ causing genes are typically not central hubs in a molecular module.

An international collaboration jointly led by scientists from Trinity College Dublin has shed new light on the origins and molecular causes of age related degenerative conditions including Motor Neuron Disease (MND).

Their disease module revealed that two proteins previously linked to some forms of the disease were part of the same molecular pathway and that they work together to cause errors in cell proliferation, which may be linked to the symptoms of the disease.

This can result in a serious genetic disease that can cause anemia, neuro - cognitive impairment, and even early death,» says the study's lead - author, Dr. Jean - Louis Guéant, director of the Inserm unit of Nutrition - Genetics - Environmental Risks at University of Lorraine and head of the Department of Molecular Medicine and Personalized Therapeutics - National Center of Inborn Errors of Metabolism at the University Regional Hospital of Nancy.

For instance, literally countless trials must be undertaken to ensure that a newly synthesized drug acts correctly on inhibiting a particular molecular pathway, and countless experiments must be performed to ensure the responsibility of that pathway as the cause of a particular disease.

CSHL is a private, non-profit research and education institution dedicated to exploring molecular biology and genetics in order to advance the understanding and ability to diagnose and treat cancers, neurological diseases, and other causes of human suffering.

Among Desmond - Hellmann's most distinguishing contributions was establishing precision medicine — which aims to collect and analyze massive amounts of data (genomic, molecular, environmental and clinical) to identify the root causes of diseases and to develop targeted therapies to treat them — as a goal for UCSF and the nation.

In addition to his other roles at the institute, he is director of the Clinical Molecular Genetics Training Program, an executive faculty member of the Joint National Institutes of Health - Johns Hopkins University Genetic Counseling Training Program, and the project officer for the Center for Inherited Disease Research in Baltimore, a research center that analyzes common disorders caused by the actions of multiple genes and interactions with the environment.

Dr. Mucke has spent most of his career uncovering the molecular and cellular mechanisms that cause memory loss and behavioral abnormalities in Alzheimer's disease and related conditions.

«Although we first became aware of prions because they cause several bizarre neurological diseases, the discovery that something so awesomely similar happens in organisms as different as humans and yeast makes us suspect that there is a fundamental, common biochemical process at work here,» said study director Susan Lindquist, PhD, professor of molecular genetics and cell biology and an investigator in the Howard Hughes Medical Institute at the University of Chicago.

To shed light on the putative diseases and causes of death in Tutankhamun's immediate lineage, we first used molecular genetic methods to determine kinship within that lineage.

Dr Søren Tvorup Christensen (Department of Biology) and Professor Lars Allan Larsen (Department of Cellular and Molecular Medicine) at the University of Copenhagen, in collaboration with colleagues in Denmark and France, have spearheaded the recent discovery which sheds new light on the causes of a range of debilitating diseases and birth defects.

Dr. Komáromy studies the molecular causes of inherited eye diseases in dogs and is working to develop gene therapies to stop vision loss.

«Having done a lot of clinical interpretation for patients, my frustration over many years is that we can not diagnose the causes of disease in most of the rare disease patients we test,» said Heidi Rehm, who is also the Chief Laboratory Director of the Laboratory for Molecular Medicine at Partners Personalized Medicine and an associate professor at Harvard Medical School.

Fruit flies serve as a good model organism for understanding the molecular mechanisms behind many human diseases — around 75 percent of disease - causing genes are found in the species in a similar form.

Kim Orth of the University of Texas Southwestern Medical Center and the Howard Hughes Medical Institute has worked to elucidate the activity of bacterial virulence factors on the molecular level, providing insights into how bacteria cause disease and how eukaryotic host cells signalin response to infection.

The FLI investigates the molecular causes for these aging - associated changes with the goal to uncover new approaches for therapies aiming to preserve the functioning of the body's own stem cells and organs thereby reducing the risk of diseases and cancer during aging.

Scientists at Washington University in St. Louis reached a new milestone in cancer research this month with the completion of a comprehensive analysis of the molecular underpinnings of the causes of the disease.

In spite of worldwide research efforts, Parkinson's disease's molecular causes are still not clear.

Besides oxidation, glycation and the subsequent formation of AGEs is one of the major molecular mechanisms causing ongoing damage in your body, which leads to disease, (premature) aging and, eventually, death.

The molecular structure of thyroid tissue is almost identical to that of gluten and therefore the immune system may start sending antibodies not only against gluten proteins but against proteins found in different organs causing autoimmune diseases.

BIO * 235, Microbiology (4 credits / 6 contact hours) $ $ Laboratory Course Fee Gen Ed Competencies: Scientific Knowledge & Understanding, Scientific Reasoning This is an introduction to general microbiology.The course is designed to meet the needs of pre-allied health students as well as biology or science majors.Topics include the structure, physiology, and molecular biology of microorganisms as well as the interactions between microbes and their hosts, including their role in the environment.Students also learn how microbes are studied and how they can cause disease and yet are essential to human well - being.

``... Initially the virus was identified in Greyhounds, and there was some speculation that the virus was exclusively causing disease in Greyhounds,» said Dr. Ruben O. Donis, chief of molecular genetics for the influenza branch at the CDC, who was part of the group of researchers.