The CCP is engaged in numerous multidisciplinary projects in other model systems (e.g. fly, zebrafish, yeast) that aim to determine how complex
molecular circuits function and evolve in response to genetic and environmental changes, cellular differentiation, evolution and disease.
Not exact matches
The potential for mind - boosting drugs and technologies has increased stunningly over the past decade as neuroscientists have unlocked the secrets of neuronal
circuits, neurotransmitters, and specific
molecular events triggering brain
functions in three interconnected cognitive domains — attention, memory, and creativity.
«Our work suggests that the apparent complexity of protein networks is deceiving, and that a
circuit involving a small number of proteins might control each cellular
function,» said senior author Shohei Koide, PhD, professor of biochemistry &
molecular biophysics at the University of Chicago.
Examples of funding areas include but are not limited to
molecular genetic analysis of relevant neural
circuit assembly and
function; genetic and epigenetic research; animal models created by genetically altering neural
circuits; and testing of new chemical entities that might be used in animal models as exploratory treatments.
We aim to identify
molecular,
circuit, and network mechanisms of cognitive dysfunction and to develop novel therapeutic approaches to restore brain
functions in AD and related disorders.
At Weizmann, Dr. Spiegel will be establishing his own independent research group which will attempt to identify the
molecular and cellular mechanisms through which experience alters the structure and
function of neural
circuits in the brain in behaviorally relevant ways and to understand how these processes, when they go awry, might give rise to psychiatric disorders.
In his studies, he uses an inter-disciplinary approach and combines physiological,
molecular, viral and computational approaches to reveal the structure and
function of retinal neuronal
circuits.