Sentences with phrase «molecular machinery of»

The molecular machinery of mitochondrial dynamics was first described in yeast and then the corresponding pathways found in mammals and humans.

Although the molecular machinery of fat loss is vast and complex, the practical application remains simple.

At ISB, we use state - of - the - art scientific instruments and cutting edge computational techniques to detect thousands of proteins at once, giving us a systems - level view of the molecular machinery of life.

«In essence, OX40 activates the IL - 9 gene in T helper cells, leading to the overproduction of IL - 9 through a powerful molecular machinery of super-enhancers that regulate gene expression,» says Dr. Xian C. Li, the director of the Immunobiology & Transplant Science Center at Houston Methodist Research Institute.

Researchers at Michigan State University have built a molecular Swiss Army knife that streamlines the molecular machinery of cyanobacteria, also known as blue - green algae, making biofuels and other green chemical production from these organisms more viable.

Like all viruses, rhinovirus C uses the molecular machinery of host cells to replicate and become infectious.

«We found that the molecular machinery of autophagy guides the degradation of components of the nuclear lamina in mammals,» said senior author Shelley Berger, PhD, the Daniel S. Och University Professor in the departments of Cell & Developmental Biology, Genetics, and Biology.

Scientists longing to sneak a peek at the molecular machinery of living cells came one step closer to that goal in March with the creation of lenses that break the limits of current light microscopy.

By dosing dogs with the gene for a myostatin precursor, Sweeney has found he can throw a wrench into the molecular machinery of myostatin signaling, removing a critical check on muscle growth and allowing deteriorating muscles to regain their strength.

Not exact matches

All living things, from viruses to humans, from bacteria to grasses, share complex molecular machinery — the whole DNA / RNA code of life and protein synthesis machinery and the ATP system of energy transfer.

Super small beings of intelligence, building and maintaining molecular machinery within all megalithic life formations may well be considered ID yet to think of such issues outside the veins of rudimentary sciences is where debates of, are to be made manifestations for thought inspired conjectures.

«This is a big step in determining the identity of key components of the molecular machinery that converts sound waves into electrical signals in the inner ear,» said the study's co-senior author, Gregory Frolenkov, of the Department of Physiology at the University of Kentucky.

Allan Jacobson, Ph.D., of the University of Massachusetts Medical School and co-founder of PTC Therapeutics, the company that developed ataluren, and David Bedwell, Ph.D., professor of the UAB Department of Biochemistry and Molecular Genetics, have sought to understand precisely how ataluren allows the ribosome, the machinery of cellular protein synthesis, to skip over these inserted stop signs and produce proteins that have normal or near - normal function.

While nature has had billions of years to perfect its complex molecular machinery, modern science is only beginning to scratch the surface of what might be possible in tomorrow's world.

We don't yet fully understand what the potential of molecular machinery is, but there are many applications that can be developed once we develop a deep understanding of how motion takes place in solids.»

Prof Leigh says: «Molecular robotics represents the ultimate in the miniaturisation of machinery.

The remaining 90 or so characterized proteins include molecular chaperones, which prevent other proteins from sticking together; translation machinery, which coaxes messenger RNAs and ribosomes to form proteins; and proteins that control the structure of RNA.

Molecular robotics represents the ultimate in the miniaturization of machinery, researchers say.

This bundling of DNA acts as a switchboard for controlling genes» activity and directs a cell's complex molecular machinery.

Many of the same molecules have been implicated in both declarative and nondeclarative memory and in species as varied as sea slugs, fruit flies, and rodents, suggesting that the molecular machinery for memory has been widely conserved.

Despite decades of study, until these experiments scientists did not fully understand the molecular mechanisms that cells use to transduce information about environmental conditions to their replication machinery.

With careful observation and experiments with mouse oocytes, the precursors of eggs, they've detected molecular signals that create an asymmetry in the machinery that drives meiosis, the cell - division process that gives rise to gametes.

Alex Dammermann and his team from the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna, together with his collaborators from the Institute of Molecular Pathology (IMP), have been investigating how the duplication of one key component of the cell division machinery, named centrioles, is coordinated with the cell cycle — the series of events that lead to a cell's division.

«In nature, polymerase, the molecular machinery that copies DNA within living cells, can sequence hundreds of millions of base pairs of DNA.

Ultimately, we hope to illuminate the intimate machinery of living molecular systems like ourselves,» says Rondelez.

New research at Rice University suggests actin filaments that control the shape of neuron cells may also be the key to the molecular machinery that forms and stores long - term memories.

«At a biochemical level, there is a lot of commonality between the molecular machinery in Drosophila and that in mice and humans,» said Dr. Ferguson.

Researchers are finding ways to assemble nanodevices and materials with the help of molecular machinery such as DNA and proteins as well as viruses, bacteria and other micro-organisms.

«We need to understand the signaling machinery that underlies these behaviors if we hope to manipulate or block them,» says John Parkinson, a molecular biologist at the University of Utah in Salt Lake City.

Mapping that dense molecular machinery is one of the most promising and challenging frontiers in medicine and biology.

Yet within each and every nucleus resides genomic machinery that is incredibly vast, at least from a molecular point of view.

By detecting the molecular machinery used by the plankton to create one of the enzymes needed to split nitrogen molecules apart, scientists appear to have discovered a new microbial source of the ocean's nitrogen - bearing nutrients.

With four molecular wheels and a carbon - based frame, the mini-roadster is a step toward devices that mimic the machinery of molecular life.

These include molecular wheels, rotors, cars, and elevators, developed by the Nobel trio, that have considerable potential as components of molecular machinery.

«We found that the same machinery that makes these tumors so aggressive also makes them vulnerable to nutrient deprivation,» said senior study author Jen - Tsan Ashley Chi, Ph.D., associate professor of molecular biology and microbiology at Duke University School of Medicine.

«Cells overexpressing the oncogene MYC will be more sensitive to inhibition of the splicing machinery,» says Ernesto Guccione, from the A * STAR Institute of Molecular and Cell Biology, who led the research.

A group of researchers, including Tomonori Kimura, a researcher at the Department of Nephrology, Osaka University (the research was conducted at the University of New Mexico, USA), identified the molecular machinery by which autophagy mediates secretion of the inflammatory cytokine, interleukin - 1 beta, in corporation with SNARE proteins.

A group of researchers identified a molecular machinery by which autophagy mediates secretion.

These are self - assembling cellular organs that perform myriad metabolic functions, and in a sense, they are molecular factories with many different pieces of machinery.

MicroRNAs lower the levels of proteins such as BDNF by binding to messenger RNA, the molecular middleman that carries instructions from genes to the protein - making machinery of the cell, and tagging it for destruction.

Together with phosphorus, sulphur and traces of iron and a few other elements, these form the molecular machinery in...

But despite more than half a century of research, the underlying molecular and cellular machinery remains a mystery.

The functional significance of this is still not clear although it is suspected that this molecular machinery may be involved in (unconscious) nutrient recognition and food and nutrient utilization.

October 21, 1994 Immortalizing agent of tumor cells found in yeast Researchers at the University of Chicago Medical Center have isolated the gene for a component of the elusive molecular machinery that plays a key role in making cancer cells immortal.

Researchers at the University of Chicago Medical Center have isolated the gene for a component of the elusive molecular machinery that plays a key role in making cancer cells immortal, offering scientists a tantalizing target for new anticancer drugs of greater effectiveness and lower toxicity.

In research reported this week in the «first release» section of the journal Science, Aseem Ansari, a professor of biochemistry and genomics at UW — Madison, and colleagues showed that their «molecular prosthesis» can help cellular machinery overcome the blockade posed by the repeats in Friedreich's ataxia.

Kriwacki also said that the paper was significant because it emphasizes the importance of the role that p53 plays in the cytosol of the cell, in addition to its role in the nucleus; his further studies are seeking to map that molecular machinery in great detail.

Hartl, a biochemist, and Horwich, a geneticist, are pioneers in the realm of cellular protein chemistry whose collaborations helped unravel the molecular machinery that assists with protein folding.

For example, PPAM alters the molecular composition of the serotonin receptor 2C through direct binding to the pre-mRNA causing a conformational change, which makes the regulated splice site more accessible to the splicing machinery, such promoting alternative exon inclusion [86].

«So we think that these proteins are part of the molecular machinery that is used for positioning genes at the inner nuclear membrane, as well as potentially for repressing them,» he said.