Sentences with phrase «molecular mechanism of the disease»

«Understanding the molecular mechanism of the disease is the key to finding a treatment that works.»

Tuncay Baubec, professor at the Department of Molecular Mechanisms of Disease at the University of Zurich, and his team have shown that one particular protein plays an important part in this process: The DNA methyltransferase 3A (DNMT3A) enzyme is responsible for positioning the methylation to the right place on the DNA.

However, many industry insiders say these changes are opening up unique opportunities for researchers who focus on translating basic science into real - world cures and are eager to explore the molecular mechanisms of disease, test hypotheses, and do work that benefits patients.

We postulate that HD mutant hPSC (embryonic or induced) lines can constitute such models and would be key to the exploration of the molecular mechanisms of the disease and ultimately allow the screening of therapeutic compounds endowed with a therapeutic potential.

His research aims to determine the underlying biochemistry and molecular mechanisms of these diseases, then develop and test novel therapeutic interventions through rigorous translational and clinical trial research.

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease.

Not exact matches

These studies helped illuminate some of the molecular mechanisms by which these fungal pathogens cause disease in the banana.

«With the Immunoscape platform, we are seeking to develop a molecular map of inflammatory diseases that will help us identify and characterize disease mechanisms,» Jessica Mega, chief medical officer for Verily, said in Monday's announcement.

Interested in the fundamental biology of real - world problems, he accumulated a wide range of research skills to better investigate the molecular mechanisms at play in neurodegenerative diseases like Parkinson's and Alzheimer's.

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

A better understanding of the molecular mechanism behind diseases and reduced body function might lead to improved drugs and therapies in the future,» says Åsa Johansson.

«We've got a new fundamental understanding of the pathological mechanisms in celiac disease, and it opens the possibility to develop new drugs against this disease,» says head of research, associate professor and ph.d., Thomas J. D. Jørgensen, Department of Biochemistry and Molecular Biology, University of Southern Denmark.

«Clearly, there are basic molecular mechanisms of aging that cause the various diseases that disable and ultimately kill us.»

These techniques are key to understanding the molecular mechanisms underlying cell function in healthy and diseased individuals and the development of diseases like cancer.

Instead of addiction being a chronic, permanent disease, recent evidence is showing that addiction is controlled by molecular switching mechanisms in the brain, that can be turned on or off with the right interventions» says Dr. Steven Laviolette.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

«Integrating these molecular imaging tools offers the opportunity to investigate the possible independent and synergistic contribution of these protein pathologies in neurodegeneration in the living brain and, therefore, greatly advance our understanding of the mechanisms of Alzheimer's disease,» said Drzezga.

Erlich and his team, which included researchers from Harvard, MIT, Stanford University, and Mount Sinai, plan next to study the effect of these eSTRs on more human diseases and better understand their molecular mechanism.

«We have identified a new molecular mechanism which directly contributes to this synapse loss — a discovery we hope could eventually lead to earlier diagnosis of the disease and new treatments.»

«We've identified a novel molecular mechanism that regulates energy expenditure and may help prevent obesity and the metabolic syndrome,» says lead author Bernat Baez - Raja, PhD, a research scientist in the Gladstone Institute of Neurological Disease.

Telomere dysfunction — alterations in the structure and / or functioning of telomeres — is one of the molecular mechanisms underlying a number of age - related diseases but, to date, little is known about its possible role in pathologies of the liver such as cirrhosis, hepatitis and liver cancer.

Students in the UBC program engage in a wide range of research: molecular mechanisms underlying cell proliferation in cancer or cell death in stroke; relating gene mutations to disease mechanisms; the social factors that determine access to health care for women living on the street.

If we want to treat the disease, we must first understand the underlying mechanism,» says Dr Jenny Björkqvist at the Department of Molecular Medicine and Surgery, Karolinska Institutet, one of the researchers behind the study.

Molecular microbiologists at the University of Southern California (USC) have uncovered intricate regulatory mechanisms within the cell that could lead to novel therapeutics for the treatment of cancer and other diseases.

Despite this clinical importance, the exact pathologic process of tumor metastasis is as yet poorly understood, and deciphering the exact molecular mechanism of this process is of paramount importance to identify specific therapeutic targets for this devastating disease.

In this review topic, researchers looked at novel translational noise studies demonstrating the molecular mechanisms that may lead to impaired vascular function, recent epidemiologic evidence of noise - induced cardiovascular disease, and the non-auditory effects of noise and their impact on the cardiovascular system.

Identifying the molecular causes of disease represented a major breakthrough in the history of medicine, moving the discipline from pattern recognition and therapeutic strategies based on syndromic pathophysiology to molecular mechanism and evidence ‐ based therapies derived from clinical trials designed on the basis of molecular mechanism.

Scientists have identified the molecular mechanism that leads to the death of neurons in amyotrophic lateral sclerosis (also known as ALS or motor neurone disease) and a common form of frontotemporal dementia.

The CPC maintains a focus on experimental pneumology with the investigation of cellular, molecular and immunological mechanisms involved in lung diseases.

The strategy of drug discovery may correct defects associated with genetic diseases as it continued to I - Stem is based on the access that pluripotent stem cells provide molecular mechanisms involved in these diseases.

What's more — in the absence of information on the underlying molecular mechanisms of her particular case — that patient will likely end up taking a one - size - fits - all pill rather than a drug tailored for her unique disease subtype.

Isaiah Mansour, an undergraduate at the University of Maine, talks about how a Maine INBRE course on the molecular mechanisms of human disease at the MDI Biological Laboratory changed his life.

In parallel, the generation of functional melanocytes from pluripotent stem cells, capable of producing melanosomes and transferring them to keratinocytes, will facilitate in vitro analysis of molecular mechanisms underlying melanocytic defects observed in genetic diseases such as neurofibromatosis or albinism.

The scientists at BSRC «Alexander Fleming» perform cutting - edge research, aiming to understand molecular mechanisms of complex biological processes in health and disease.

Conclusions: The identification of gene expression alterations as a function of hypoxia and recovery from hypoxia is important to understand the molecular mechanisms underlying retinal dysfunction associated with a variety of diseases.

This unit is devoted to study the molecular mechanisms underlying these diseases, with the goal of developing effective therapeutic strategies.

Examination of such mechanisms by which the brain naturally protects itself may lead to more selective cellular and molecular targets, as well as new therapeutic strategies against brain disease.

The MDC's mission is to study molecular mechanisms in order to understand the origins of disease and thus be able to diagnose, prevent and fight it better and more effectively.

«Sweden's strong track record in biobanking and clinical characterization of patient cohorts should allow important questions to be addressed related to the molecular mechanisms and diagnosis of human disease», says Kerstin Lindblad - Toh.

As an example, the ICGC / TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) project, co-led by our group, is leveraging cloud solutions to globally standardize and analyze cancer genomics data, with the aim of uncovering commonalities and differences between molecular disease mechanisms in disparate cancer entities.

She is passionate about understanding molecular mechanisms underlying the development of oral infectious disease, as well as mechanisms important in maintaining health.

Taal, M. W., Omer, S. A., Nadim, M. K. & Mackenzie, H. S. Cellular and molecular mediators in common pathway mechanisms of chronic renal disease progression.

Molecular mechanism underlying diseases (conformational diseases, cystic kidney disorders, neuromuscular diseases, inflammation, iron - related diseases, disorders of human reproduction, osteoporosis and bone diseases) are being investigated by many groups with robust animal and cellular models and patients» biological samples.

Monogenic diseases are often lacking of physiological human cellular models dedicated to the study of the molecular mechanism implicated in the development of the pathology.

We aim to unravel the molecular mechanisms of the central nervous system's (CNS) response to neurovascular changes, with the ultimate goal to develop novel therapeutic strategies for neurological diseases.

Dr. Tarazi studies the behavioral, genetic, molecular, and cellular mechanisms that mediate the actions of dissimilar psychotropic drugs by using animal models that mimic the core symptoms of different neuropsychiatric diseases.

To cite a few instances, polymerase chain reaction (PCR), a molecular method developed over three decades ago, has been widely applied in disease diagnosis, disease mechanism deciphering, and prognosis prediction; the elucidation of tyrosine kinase activity in cancer cells has led to the development of novel drugs for cancer treatment; and the identification of proteins and genetic molecules by molecular methods as biomarkers for disease diagnosis and prognosis has been drawing great interest.

Research activities are also concentrated on the identification of disease mechanisms in vertebrates with the ultimate goal to identify molecular targets and cells with therapeutical potential.

In further studies, we will try to understand the molecular mechanisms underlying these processes and develop therapeutic strategies in the treatment of cardiovascular diseases.

Dr. Semenza's research interests include the molecular mechanisms of oxygen homeostasis; gene and stem cell therapy for ischemic cardiovascular disease; the role of HIF - 1 in cancer; and protection of the heart against ischemia - reperfusion injury.