Sentences with phrase «molecular mechanisms of resistance»
Not exact matches
Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well - known «resistance» mutations in the gene called epidermal growth factor receptor (EGFR).
https://www.sciencedaily.com/
Adrian Mulholland, Professor of Chemistry at the University of Bristol, said: «This work shows how molecular simulations can reveal mechanisms of drug resistance, which can be subtle and non-obvious.
«Many mechanisms of resistance to Bt proteins have been proposed and studied in the lab, but this is the first analysis of the molecular genetic basis of severe pest resistance to a Bt crop in the field,» said Bruce Tabashnik, one of the paper's authors and the head of the Department of Entomology in the UA College of Agriculture and Life Sciences.
She spoke with ASBMB Today about her lab's work exploring molecular chaperones and mechanisms of bleach resistance in bacterial and human cells.
Taken together, these observation impinge on one central problem: the development of rational targeting strategies aimed at overcoming therapeutic resistance require the precise elucidation of the molecular mechanisms whereby carcinoma cells that undergo EMT acquire the functional traits that render them resistant to conventional therapy.
She started her scientific career as an undergraduate and then PhD fellow at the Pasteur Institute, Paris, France, uncovering the molecular basis of IFN - induced OAS proteins in mediating resistance to West Nile virus infection and characterizing the molecular mechanism of action of DC - SIGN surface lectin polymorphisms that associate with severe Dengue hemorrhagic fever.
Such a strategy will require a better understanding of the molecular mechanisms of antibiotic resistance, so in this study, the researchers solved the crystal structure of the resistance enzyme aminoglycoside phosphotransferase (4)- Ia in complex with the aminoglycoside hygromycin B.
We seek to «Track and Treat» the cancer cells present in patients» tissues by using lineage tracing, as well as sequencing technologies, to determine the molecular mechanisms responsible for the dissemination of cancer cells to various organs, and resistance to current therapies.
Similar approaches could be used to study the molecular basis of response to a given therapy, as well as mechanisms of resistance to treatment.
His research interest focuses on 1) development and application of TALEN and CRISPR technologies for targeted genome editing in plant species, and 2) molecular mechanism of plant / microbe interactions and crop disease resistance engineering by using the bacterial blight of rice as a model.
These findings provide a rich resource for researchers investigating the molecular mechanism of drug resistance.
Areas covered by Cancer Cell include, but are not limited to, molecular and cellular mechanisms of cancer, mechanisms for the sensitivity and the resistance to cancer therapies, and development of better cancer therapies.
«By understanding how the environment in which the parasite lives influences its susceptibility to drugs and the molecular mechanisms of drug resistance, we hope to be able to develop new intervention strategies to combat visceral leishmaniasis in Brazil.»
The papers, published in the Journal of Antimicrobial Chemotherapy and in the journal Molecular Microbiology, detail the team's discovery of two mechanisms associated with β - lactam antibiotic resistance.
Uberuaga has had three outstanding scientific achievements over the past 10 years: accelerated molecular dynamics method development, amorphization resistance of complex oxides, and the discovery of a new mechanism for point defect recovery at interfaces.
The main hypothesis includes a stress preconditioning response mechanism, in which it is believed that periods of nutrient deprivation displays a beneficial mild stress that results in molecular adaptive changes in various tissues, which increases the organism's resistance to bigger stressors such as excitotoxic and oxidative injury, including ischemia (33,71).
A study in 2013 found that being leptin resistant predicts obesity, 4 Jung, CH., Kim, MS., «Molecular mechanisms of central leptin resistance in obesity,» Archives of Pharmacal Research 36 (2)(2013): 201 - 7.
The present review will discuss the trends in fructose consumption, the metabolic consequences of increased fructose intake, and the molecular mechanisms leading to fructose - induced lipogenesis, insulin resistance and metabolic dyslipidemia.