Sentences with phrase «molecular mechanisms of the cancer»
However, the molecular mechanisms of the cancer - promoting effects of capsaicin are not clear.
http://cancerres.aacrjournals.org/
Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well - known «resistance» mutations in the gene called epidermal growth factor receptor (EGFR).
The Center theme is to elucidate the molecular mechanisms of cancer and define how environment, diet, genetics and epigenetics influence susceptibility to developing cancers.
Onyx - 015 is an example of the new wave of cancer therapies emerging based on researchers» growing understanding of the molecular mechanisms of cancer and viruses.
And in 2006, Kristiina Vuori, M.D., Ph.D., an authority on the molecular mechanisms of cancer metastasis, assumed that leadership role.
Dr. Massagué gave his ambitious new colleague free rein to pursue the molecular mechanism of cancer metastasis even though no research of this sort had ever been attempted in his lab, and Dr. Kang had limited background in cancer research and no experience in genomics.
His laboratory focuses on the cellular and molecular mechanisms of cancer progression.
Not exact matches
Similar to capsaicin, tumor necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor necrosis factor (50).
This work confirmed these suspicions and discovered novel molecular genetic mechanisms driving the evolution of HPV - inactive cancers.
«We've long known that NF - kB promotes cancer development by subverting apoptosis, an internal safety mechanism that otherwise would cause cancer cells to self - destruct,» says principal investigator Denis Guttridge, PhD, professor of molecular virology, immunology and medical genetics and of molecular and cellular biochemistry.
We hope that these new insights will allow us to increase our understanding of the molecular mechanisms that result in cancer and to more effectively treat this aggressive type of leukemia.»
«We reasoned that if we could identify microRNAs that regulate the progression of colorectal cancer, we could use them as molecular probes to better understand the molecular and cellular mechanisms that govern liver colonization,» says Tavazoie, who is Leon Hess Associate Professor and head of the Elizabeth and Vincent Meyer Laboratory of Systems Cancer Bicancer, we could use them as molecular probes to better understand the molecular and cellular mechanisms that govern liver colonization,» says Tavazoie, who is Leon Hess Associate Professor and head of the Elizabeth and Vincent Meyer Laboratory of Systems Cancer BiCancer Biology.
These techniques are key to understanding the molecular mechanisms underlying cell function in healthy and diseased individuals and the development of diseases like cancer.
«This remodeling process of the cell proteome by autophagy is an important immune - suppressive survival mechanism for Ras - driven cancers, and inhibiting autophagy can provide a means to target these aggressive cancers,» notes White, who is also a distinguished professor of molecular biology and biochemistry at Rutgers School of Arts and Sciences.
The molecular mechanisms involved in the development of cancer have been uncovered by extensive research over the past 30 years, culminating in The Cancer Genome Atlas, a National Institutes of Health project that identified and characterized many genetic mutations that fuel ccancer have been uncovered by extensive research over the past 30 years, culminating in The Cancer Genome Atlas, a National Institutes of Health project that identified and characterized many genetic mutations that fuel cCancer Genome Atlas, a National Institutes of Health project that identified and characterized many genetic mutations that fuel cancercancer.
Understanding the molecular mechanisms underlying Aurora kinase - overexpressing tumours will help in the design of targeted and personalised cancer therapy,» said Dr Linda Chuang, Senior Research Scientist at CSI Singapore, who is the first author of the study.
The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patCancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patcancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.
«We challenged a current dogma in the field that emphasized PLK1's role in mitosis (cell division) as a primary mechanism for cancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medcancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of MedCancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of MedCancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medicine.
Understanding the physiological mechanisms that cause or, as in this case, prevent genetic instability is a basic question in Molecular Biology and Biomedicine which is of vital importance in the research against cancer, given that genetic instability is a distinctive feature of tumorous cells.
The study, published Nov. 17 by Proceedings of the National Academy of Sciences, shows that triclosan causes liver fibrosis and cancer in laboratory mice through molecular mechanisms that are also relevant in humans.
Researchers from the University of Missouri School of Medicine have identified a molecular mechanism that operates in memory T cells that could be manipulated to produce and maintain more memory T cells in the body, a finding that could improve vaccinations and cancer immunotherapies.
Now, researchers from the University of Missouri School of Medicine have identified a molecular mechanism that operates in memory T cells that could be manipulated to produce and maintain more memory T cells in the body, a finding that could improve vaccinations and cancer immunotherapies.
And with non-melanoma skin cancers being the most frequent human tumors, there is clearly a tremendous need to understand the underlying molecular mechanisms, to allow the development of drugs to treat these types of cancer.
Telomere dysfunction — alterations in the structure and / or functioning of telomeres — is one of the molecular mechanisms underlying a number of age - related diseases but, to date, little is known about its possible role in pathologies of the liver such as cirrhosis, hepatitis and liver cancer.
Jean - Christophe Larsimont and colleagues used state of the art genetic mouse models to dissect the functional role and molecular mechanisms by which Sox9 controls skin cancer initiation and invasion.
In a new study published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers at Huntsman Cancer Institute and the University of Utah have identified a molecular mechanism that triple negative breast cancer cells use to survive andCancer Institute and the University of Utah have identified a molecular mechanism that triple negative breast cancer cells use to survive andcancer cells use to survive and grow.
Students in the UBC program engage in a wide range of research: molecular mechanisms underlying cell proliferation in cancer or cell death in stroke; relating gene mutations to disease mechanisms; the social factors that determine access to health care for women living on the street.
The «small, but perfectly formed» flies will help scientists sort out the mechanisms governing cell size and number during development, says molecular biologist Sally Leevers of the Ludwig Institute for Cancer Research in London.
Molecular microbiologists at the University of Southern California (USC) have uncovered intricate regulatory mechanisms within the cell that could lead to novel therapeutics for the treatment of cancer and other diseases.
This research confirmed that suspicion and discovered molecular genetic mechanisms that drive the evolution of HPV - inactive cervical cancers.
Dr. Qimin Zhan, Principal Investigator of this project and the Director of State Key Laboratory of Molecular Oncology, Chinese Academy of Medical Sciences Cancer Hospital, said, «For sure, the findings of this project provide novel insights into understanding of underlying mechanism for this malignant ESCC, and enable us to explore potential diagnostic biomarkers and drug targets, and to develop useful clinical therapeutic approaches.
Moreover, our previous study found that regular use of aspirin after diagnosis was associated with longer survival among the 15 % to 30 % of patients with colorectal cancer and with a mutation in phosphatidylinositol -4,5-bisphosphate 3 - kinase, catalytic subunit alpha (PIK3CA [NCBI Entrez Gene 5290]-RRB-, one of the PI3K family genes.30 Markedly improved survival associated with aspirin according to PIK3CA status was also found in an analysis within a separate clinical trial cohort.31 Further investigations for the joint effect of these genes would be helpful to better understand the underlying molecular mechanisms of aspirin, NSAIDs, and colorectal cancer.
The group at the Ludwig Institute for Cancer Research at the University of Oxford, led by Gareth Bond, Ph.D., performed complex experiments to confirm the molecular mechanism that linked the variant with cancer and taCancer Research at the University of Oxford, led by Gareth Bond, Ph.D., performed complex experiments to confirm the molecular mechanism that linked the variant with cancer and tacancer and tanning.
Cellular mechanisms and molecular regulation of epithelial morphogenesis in development and cancer.
By gaining an understanding of this underlying mechanism, this discovery has the potential to vastly help researchers learn what happens at the molecular level when this mechanism is disrupted — such as in cancer or when exposed to a particular drug.
Our laboratory is interested in exploring the molecular mechanisms that drive the production of cancer stem cells and specifically in dissecting the microRNA / transcription factor circuitry that connects such differentiation metastability to tumour aggressiveness.
This better understanding of BCX's molecular mechanism could lead to dietary recommendations for patients undergoing chemotherapy for lung cancer and for those who have survived, said Wang, who is also a professor at the Friedman School.
Johanna Roostalu is a Sir Henry Wellcome Postdoctoral Fellow at the Cancer Research UK London Research Institute where she is working on a project to elucidate the molecular mechanism of spindle assembly and microtubule self - organization using a combination protein biochemistry, fluorescence microscopy, microfluidics and mathematical modeling.
Lloyd Trotman Molecular mechanisms of tumor suppression; cancer modeling and treatment; molecular cancer visualization; PTEN rMolecular mechanisms of tumor suppression; cancer modeling and treatment; molecular cancer visualization; PTEN rmolecular cancer visualization; PTEN regulation
The tumorigenesis mechanisms of colorectal cancer have been widely studied at a molecular level.
As an example, the ICGC / TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) project, co-led by our group, is leveraging cloud solutions to globally standardize and analyze cancer genomics data, with the aim of uncovering commonalities and differences between molecular disease mechanisms in disparate cancer entities.
We seek to «Track and Treat» the cancer cells present in patients» tissues by using lineage tracing, as well as sequencing technologies, to determine the molecular mechanisms responsible for the dissemination of cancer cells to various organs, and resistance to current therapies.
Almost every mechanism of cancer cells tested was reported to be affected by these drugs, a phenomenon hardly to be traceable back to one or a few underlying molecular targets.
Her work in the COBRE for Cancer Research and Development has traced the molecular mechanisms underlying the effect of a pathway called mTOR.
To cite a few instances, polymerase chain reaction (PCR), a molecular method developed over three decades ago, has been widely applied in disease diagnosis, disease mechanism deciphering, and prognosis prediction; the elucidation of tyrosine kinase activity in cancer cells has led to the development of novel drugs for cancer treatment; and the identification of proteins and genetic molecules by molecular methods as biomarkers for disease diagnosis and prognosis has been drawing great interest.
Dr. Phillip Sharp's research has centered on the molecular biology of gene expression relevant to cancer and the mechanisms of RNA splicing.
The potential role of lycopene for the prevention and therapy of prostate cancer: From molecular mechanisms to clinical evidence.
Dr. Semenza's research interests include the molecular mechanisms of oxygen homeostasis; gene and stem cell therapy for ischemic cardiovascular disease; the role of HIF - 1 in cancer; and protection of the heart against ischemia - reperfusion injury.
The findings also support using the Tff1 - knockout mouse model for in vivo studies of molecular mechanisms in gastric cancer.
Our ultimate goals in this activity include (1) a better understanding of the molecular mechanisms governing cellular processes and especially those involved in certain kinds of diseases such as cancer and (2) the development of computational tools that can be used for diagnostic / prognostic purposes based on genomic data.