Sentences with phrase «molecular model analysis»

Liu came to him to request a molecular model analysis to learn why salt made it easier to melt metals with chalcogens and get them to react.

Not exact matches

The work applies a data analysis model for the growth and maturation of biomedical research to characterize the progress of research on the pharmaceutical chemistry of oligonucleotide therapeutics, as well as the molecular targets, for their actions.

In addition to Loring, Boland and Nazor, authors of the study, «Molecular analyses of neurogenic defects in a human pluripotent stem cell model of Fragile X syndrome,» were Ha T. Tran, Candace L. Lynch and Pietro Paolo Sanna of TSRI; Attila Szücs of the University of California, San Diego, and Eötvös Loránd University; Ryder Paredes of California State University, Channel Islands; and Flora Tassone of the University of California, Davis.

Examples of funding areas include but are not limited to molecular genetic analysis of relevant neural circuit assembly and function; genetic and epigenetic research; animal models created by genetically altering neural circuits; and testing of new chemical entities that might be used in animal models as exploratory treatments.

Our teams develop novel approaches as well as utilize routine routes to synthesize molecular, nanostructured, and solid - state systems; analyze the samples with multiple instruments; and model the results for detailed insight and to predict new systems for synthesis and analysis.

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.

More specifically, we use large - scale data acquisition and quantitative modelling of phenotypes and molecular profiles, systematic perturbations (such as drugs or high - throughput genetics) and computational analysis of non-linear, epistatic interaction networks.

The Intel «Cherry Creek» supercomputer — which ranks among the world's fastest and most powerful supercomputers for its combination of speed, power, and energy efficiency — cut down calculation time on complicated analyses from years to days, advancing fields such as genomics and bioinformatics, medical and climate research, molecular modeling, and data analytics.

Genetic Engineering and Model Validation: engineering and generation of customised genetically modified mouse models, generation of genetically modified ES cells, genotyping, analysis of gene expression, model validation by molecular analysis, CRISPR / Cas9 nucleases technModel Validation: engineering and generation of customised genetically modified mouse models, generation of genetically modified ES cells, genotyping, analysis of gene expression, model validation by molecular analysis, CRISPR / Cas9 nucleases technmodel validation by molecular analysis, CRISPR / Cas9 nucleases technology

Much of the research carried out today on rodent models generates high resolution image data, allowing characterization and analysis of brain molecular distribution, gene expression, and connectivity.

This framework will be built upon available open - source deep learning platforms that can be adapted to address different aspects of the cancer process as represented by JDACS4C's challenge topics: 1) understand the molecular basis of key protein interactions; 2) develop predictive models for drug response; and 3) automate the extraction and analysis of information from millions of cancer patient records to determine optimal cancer treatment strategies.

Moreno H, Lewandowski N, Bordelon Y, Brickman A, Angulo S, Khan U, Muraskin J, Griffith E, Wasserman P, Menalled L, Vonsattel J.P, Marder K, Small S.ARegional vulnerability in Huntington's disease: fMRI - guided molecular analysis in patients and a mouse model of disease.

Clinical Trials Research and Billing First in Human / Early Phase PET in Oncology Case - Based Dose Reduction in Pediatric Nuclear Medicine: Practical and Necessary Radioiodine Therapy for Hyperthyroidism: The State of the Art Spondylodiscitis: Role of Imaging for Diagnosis and Monitoring Treatment Response Current Status and Future Prospects: PET and SPECT Instrumentation Alternative Payment Models and Value - Based Health Care: Nuts and Bolts Maximal Tolerated Activity of Radioactive Iodine for Metastatic Thyroid Cancer Teaching Old Radiopharmaceuticals New Tricks Intraoperative Detection Devices and Probes Molecular Imaging of Lung Inflammation Standardization of Advanced PET / SPECT Data Acquisition and Analysis Thyroid Cancer Management: Novel Therapeutics and Management Options Targeting Radionuclide Therapy in Various Non-Malignant Arthritic Conditions Using Radiosynoviorthesis (RSO) Are You Prepared for a Radiation Accident?

We perform a broad range of molecular and cellular investigations ranging from DNA mutation and RNA expression analysis to translational in vivo models utilized to understand the biology of the genetic alterations.

Required capabilities include kinetic turbulence simulations, related three - dimensional fluid simulations with gyro - Landau kinetic extensions, large - scale molecular dynamics simulations of materials, and couplings of lower - dimensional models (for fast analyses) to simulate interactions between zones and particle species.

Thus, the focus of research in the Giovannoni lab is molecular and genetic analysis of fruit ripening and related signal transduction systems, using tomato as the model system.

Microarray analysis of prostate cancer progression to reduced androgen dependence: studies in unique models contrasts early and late molecular events.

Targets of research range from basic molecular and cellular mechanisms, the manipulation of these mechanisms in animal models, analyses of the genes and gene products in cardiovascular disease, and clinical research that seeks to improve diagnosis and therapy for patients.

Because of robust off - target effects of most RIPK2 inhibitors, we carried out molecular modeling (docking) and cheminformatics analyses by carefully analyzing the only known crystal structure of RIPK2 in association with the c - ABL kinase inhibitor ponatinib (https://www.rcsb.org/pdb/explore/macroMoleculeData.do?structureId=4C8B).

Molecular and genetic analysis of fruit ripening and related signal transduction systems, using tomato as the model system

The Czech Centre for Phenogenomics and the Institute of Molecular Genetics of the ASCR, v.v.i., would like to invite you to a seminar «Gait Analysis in Animal Models of Human Disorders» presented by Dr. Thomas G. Hampton (Mouse Specifics, Inc., Boston, USA).

Using molecular modeling (docking) and chemoinformatics analyses, we used the RIPK2 / ponatinib crystal structure and searched in chemical databases for small molecules exerting binding interactions similar to those exerted by ponatinib.

Systems biology and bioinformatics analyses are employed to compare research results from model organisms with human aging to develop models and predictions for causative molecular mechanisms and circuits that influence human aging.

Specifically, developing systems biology data analysis framework to quantify and model diabetes and cancer molecular pathways

in the short - term, further understand the molecular pathways involved in the process of oncogenic transformation in human hemopathies, using fine structural in vivo analysis of clinical materials, combined with the development of functional in vitro experimental systems and in vivo models of genetically modified mice;

Some of these new tools relate to strengths on the PNNL campus, said Teeguarden, including modeling and data analytics, analytical chemistry, toxicology, and the multi-omics analyses made possible by instrumentation and experts at the Environmental Molecular Sciences Laboratory, a national science user facility.