Sentences with phrase «molecular phenotypes»

10:35 - 10:55 Johan Lindberg, Swetox and Jonathan Benskin, Stockholm University, Dept. Applied Environmental Science Molecular phenotyping in zebrafish using metabolomics

Furthermore, because the genomic sequences orchestrate a biochemical system that is much more information ‐ rich than the genome, the vast majority of the measured molecular phenotypes must represent «molecular spandrels», that is phenotypes that are not independent of each other, and instead co ‐ determined by the same genomic sequences.

However, as the genome is finite in length, it can not define precisely optimal values for the quantitative parameters of the experimentally identified molecular phenotypes.

We hypothesize that upon retinal neuronal damage MG or RPE cells undergo defined and controlled changes in cellular and molecular phenotype towards a cell with progenitor properties — this process that we are studying we call regenerative reprogramming.

The groups plan to further characterize gene activity in tissues by analyzing several molecular phenotypes, or properties of cells - such as which genes are turned on and off, the various ways genes are regulated and the proteins that cells produce based on such regulation.

Research initiatives in his laboratory include analysis of the interaction between host immune factors (e.g., macrophages) and muscle stem cell remodeling during HIV - associated muscle wasting, and the molecular phenotyping of aging and identification of biomarkers for anabolic response.

«We show that the molecular phenotypes of these neurons track quite tightly to their developmental origin, with anatomy making some interesting contributions as well.»

We want to find the molecular phenotypes that distinguish health from disease, and that's what metabolomics provides.

This Epigenesys - funded project aims to apply system genetic approaches based on Bayesian networks to model regulatory pathways between genetic variants and molecular phenotypes measured in blood cells.

The screens in the German Mouse Clinic are designated to the areas of behaviour, bone and cartilage development, neurology, clinical chemistry, eye development, immunology, allergy, steroid metabolism, energy metabolism, lung function, vision and pain perception, molecular phenotyping, cardiovascular analyses and pathology

Applied to large multi-omics datasets from the BXD mouse genetic reference population, novel associations between genes and clinical and molecular phenotypes, and regulatory relations between genes could be identified.

Although the genes implicated in these disorders are involved in a variety of pathways, most of them share a molecular phenotype: high (and often transcript ‐ specific) expression in retinal tissue.

To identify and group interacting parameters involved in the development of clinical and molecular phenotypes.

By integrating 36 brain transcriptomes and proteomes and a de novo assembled genome of the offspring we investigate the molecular reaction to increased CO2 as well as the heritability of the molecular phenotype.

Importantly, there is a clear signature of the parents» sensitivity to high CO2 in the molecular phenotype of the offspring expressed by the differential regulation of genes controlling the circadian rhythm indicating adaptive potential through natural standing variation.

Broadly speaking, however, analysis of transcriptional regulation at the single cell level has provided evidence for a strong stochastic element: genetically identical cells within the same environment show significant variation in molecular phenotype, in a fluctuating manner [24].

I am interested in how this variation affects the cellular and molecular phenotypes that mediate complex trait variation.