Since the 1970s, however, work on isolated chunks of nervous - system tissue has identified a host of
molecular players in memory formation.
Since the original work was done more than 30 years ago, many follow - up studies have focused on identifying other
molecular players involved in circadian rhythms, teasing out how they interact with one another and discovering how disruptions to this fundamental part of our physiology may lead to numerous health problems.
A dizzying number of genetic transcripts, proteins and
other molecular players alternatively glom together or fall apart, turning on or tuning down countless patterns of gene expression that keep our cells, organs and bodies humming along with the Earth's daily rotations.
«Molecular pilot light prepares body's heating system for the cold: Animal study discovers
new molecular player in burning sugar and fat to boost metabolism.»
«To have the list
of molecular players that make each of these subtypes different from one another gives us an important handle on learning more about what that cell type does and how we can manipulate only that subtype,» said Dymecki.
«This new study uncovers for the first time the dynamic of stem cells during wound healing and identifies new
molecular players associated with skin regeneration.
The paper focuses on two
key molecular players in the story of influenza infection: a human protein called TRIM25, which was recently discovered to play an important role in the human immune response to flu infection; and a protein called NS1 present in all strains of the influenza A virus and shown to bind TRIM25 to keep it from doing its job.
Magdalena earned her PhD from Albert Einstein College of Medicine with Dr. Anna Francesconi, focusing on elucidating cellular /
molecular players involved in regulation of dendritic spine morphogenesis by metabotropic glutamate receptor signaling.
In last years, the «Stress and Cancer» laboratory has identified two
new molecular players of the oxidative stress response, the miR - 200 family of microRNA and the transcription factor JunD.
It's the first step in making proteins, the stuff of all the structures in the body and
molecular players in the countless dramas unfolding every second as cells execute tasks that enable our organs to function.
Scientists have identified
the molecular players central to an incurable brain injury common in premature babies, and have shown how such injuries might one day be treated, sparing people from lifelong conditions such as cerebral palsy.
Other
molecular players, lincRNAs for example, orchestrate many of the processes of life (SN: 12/17/11, p. 22).
Now scientists have figured out
the molecular players that make it so.
In each branch of these networks, layers of regulatory controls constantly change the nature and abundance of
the molecular players.
Molecular players might include acetone (the stuff in nail polish remover), methyl formate, and ethylene glycol (antifreeze), she notes.
It's a «provocative» paper, says molecular biologist Ellen Filvaroff of Genentech in South San Francisco, California, who has worked previously on
the molecular players involved in fracture healing.
A genetic approach allowed the researchers to tease apart
the molecular players involved in this process.
«Gaining familiarity with
the molecular players in a behavior — as this new tool promises — may someday lead to clinical interventions targeting dysfunctional brain states.»