Sentences with phrase «molecular signaling pathway»

But what scientists did not know is how the mutations trigger a molecular signaling pathway that leads to the death of photoreceptor cells.

A molecular signaling pathway determines the worm's life - span.

Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy - induced neuropathy and HIV.

Now, Dr. Katharina Walentin and Professor Kai Schmidt - Ott of the Max Delbrück Center for Molecular Medicine (MDC) Berlin - Buch have discovered a new molecular signaling pathway which regulates the development of the placenta.

In McGlinn's mutant mouse, the disrupted pattern - forming genes belonged to the molecular signaling pathway named Sonic hedgehog.

But as with many other types of treatments, treating tumors with PDT can stimulate molecular signaling pathways that support tumor survival.

Moreover, these sex - specific behavioral differences are accompanied by sex differences in molecular signaling pathways in the striatum brain region.

Study authors then further refined the process, identifying additional molecular signaling pathways that drive formation of critical stomach cell types of the fundus.

We are particularly interested in how several molecular signalling pathways control the size to which the worm grows (about 1 mm long).

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

Her group aims to unveil the molecular signaling pathways that are relevant for cardiac disease.

Not exact matches

«Certainly at the molecular level, research on signal pathways and chemistry are important,» Jock says.

By using a combination of advanced genetics, molecular approaches, and microscopy techniques, they found that this signaling pathway is used in the adult brain in a completely novel way.

And the mutation that bestows such remarkable longevity is a gene that happens to regulate activity in the insulin / IGF signaling pathway, says Robert Schmookler - Reis of the University of Arkansas, a molecular geneticist who discovered the relationship between the mutation and the superworm's extraordinary life.

Dr. Copland says that the study shows that molecular work decoding cancer signaling pathways and the effect of agents on those pathways is possible — and necessary.

«We discovered that three particular proteins involved in the Wnt signaling pathway aren't just involved in the development of severe illnesses, but also in the qualitative refinement of highly developed tissue,» says co-first author Claudio Cantù from the molecular biologist research group lead by Prof. Konrad Basler.

«Signaling pathways and gene expression profiles are very different in cells that grow in 2D and 3D cultures,» says Oksana Sirenko, a research scientist at Molecular Devices in Sunnyvale, California.

The team's next step is to zoom in on the molecular mechanisms that control how the Wnt signaling pathway interacts with the nail stem cells to influence bone and nail growth.

The molecular structure of the two key lipid components in the newly discovered signaling pathway are ceramide (right) and cardiolipin (upper left).

Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.

«Recently, the attention of scientists has been attracted to endocrine - disrupting chemicals (EDCs), compounds that are suspected of promoting the development of various metabolic disorders via their capacity to impact hormonal and metabolic signaling pathways,» said lead author Shane Regnier, a doctoral candidate at the University of Chicago's Committee for Molecular Metabolism & Nutrition.

As a clinician - scientist with a translational research focus, Dr. Deininger is heading an extramurally funded research laboratory that is dedicated to the study of signaling pathways, drug resistance, and new molecular therapies in leukemia.

When analyzing the biology behind the molecular alterations in these tumors, the researchers found that nearly three - quarters of cervical cancers had genomic alterations in either one or both of the PI3K / MAPK and TGF - beta signaling pathways, which may also provide targets for therapy.

Research of the last decade revealed that the CNS and the vascular system share many molecular mechanisms and signaling pathways, which is also known as neurovascular link.

«Almost nothing is known» about the molecular and cellular mechanism by which water is detected in the mouth and throat, and the neural pathway by which that signal is transmitted to the brain, says Zachary Knight, a neuroscientist at the University of California, San Francisco.

«TWEAK and its signaling receptor, Fn14, have emerged as a fundamental molecular pathway regulating tissue responses after acute tissue injury and in many different contexts of chronic injury and disease» said Linda Burkly, Ph.D., Senior Distinguished Investigator, VP, Biogen, Inc., and co-senior author on the current study.

To figure out how signalling pathways work, molecular biologists carry out and validate experiments, sometimes over many years, to characterise the exact interactions taking place between proteins.

The team identified a critical pathway of molecular signals which throw a lifeline to cancer cells, enabling them to survive even though they contain vast DNA errors which would usually trigger cell death.

Professor Heiko Lickert, director of the IDR, in collaboration with Professor Gunnar Schotta of LMU München, showed that the Wnt / β - catenin signaling pathway regulates Sox17, which in turn regulates molecular programs that assign pluripotent cells to the endoderm, thus inducing an initial differentiation of the stem cells.

«We discovered that male zebrafish have a very important set of structures on their pectoral fins that they use for breeding and that these structures secrete a potent molecular inhibitor of a key signaling pathway to aid their cycles of regular replacement,» explains senior author Kenneth Poss of Duke University Medical Center.

While our studies provide important insight into the molecular pathophysiology of the mutant ACVR1 receptor on the BMP signaling pathway in FOP, interpretations of these data are limited to those allowed by the experimental systems used.

The effects of mutations and other genetic changes in cancer cells play out in the complex networks of molecular interactions or «signaling pathways» involved in cell growth, proliferation, and other hallmarks of cancer biology.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

Molecular genesis of cutaneous melanoma pathways; rous avian sarcoma homologue (Ras); v - raf murine sarcoma viral oncogene homologue B1 (BRAF); mitogen - activated protein kinase (MEK); extracellular signal - regulated kinase (ERK); microphthalmia transcription factor (Mitf); phosphatidylinositol - 3 kinase (PI3K); murine v - akt oncogene homologue (Akt).

Dr. Joyal has over 20 years of drug discovery experience with expertise in cell and molecular biology, particularly in the areas of receptor biology, cell signaling pathways, and assay development.

Current projects in the laboratory include: 1) functional screens of ubiquitin ligases to identify novel cancer drug targets; 2) defining the molecular regulation of breast cancer metastasis to the brain; and 3) understanding signaling pathways that influence the response of cancer cells to chemotherapy.

Signaling pathways function a bit like very accurate games of molecular telephone.

We use neuronal cultures, induced pluripotent stem (iPS) cells and transgenic and gene - targeted mouse models to study the differential effects of apoE3 and apoE4 on cell signaling pathways and cytoskelatal structure and function at molecular, cellular and behavioral levels.

While core pathways for BR metabolism and signaling have largely been defined, little is known about the molecular mechanisms regulating BR homeostasis and how these in turn modulate plant development.

His team uncovered a genetic element known as a silencer that plays a crucial role in shaping the molecular identity of CD4 cells, as well as the immunological signaling pathways in which CD4 and CD8 molecules participate along with the T cell antigen receptor.

We have identified several molecular targets such as Bcl - xL, Bcl - 2, and survivin, along with upstream signaling intermediates such as PI -3-kinase, Akt, and the canonical and non-canonical NF - κB pathways that control the activities of OX40.

The results, which were published and highlighted in Molecular Systems Biology, give researchers a more complete view of cell signaling pathways.

Thus, leptin determines the extent of bone formation by modulating, via sympathetic signaling, osteoblast proliferation through two antagonistic pathways, one of which involves the molecular clock.

This PI3K - AKT Signaling poster provides an overview of the key molecular targets and their interactions involved in this pathway.

So today we'll discuss insulin signaling and leptin signaling pathways, we'll talk about the molecular basis of insulin resistance and leptin resistance, and then we'll try to talk about at the end how insulin and leptin signaling interacts to regulate appetite, food intake and metabolism.

Bacterial toxins are valuable molecular tools for elucidating signaling pathways in cells [53].

In 2014, Anna earned her Ph.D. in Cell & Molecular Biology at Drexel University where she focused on characterizing Sonic Hedgehog signaling pathway and its role in Amyloid Precursor Protein (APP) processing, Amyloid - beta clearance, and trafficking to primary cilia.

Notably, we found «Protein processing in endoplasmic reticulum» and «PI3K - Akt signaling pathway» might be impaired in DACD pathogenesis, while Growth factor receptor - bound protein 2 might be a crucial protein as a molecular target of the neuroprotective effects of ZBPYR.

Michael A. Davies, M.D., Ph.D., Associate Professor and Deputy Chairman, Department of Melanoma Medical Oncology and Associate Professor, Department of Systems Biology, Department of Translational Molecular Pathology University of Texas MD Anderson Cancer Center «Integrated interrogation of oncogenic signaling pathways, immunology, and heterogeneity in cancer»

Kelly earned her Ph.D. in Cell and Molecular Biology from the University of Pennsylvania studying the role of the EGF - Ras - ERK signaling pathway in cell fate specification.