The phrase
"molecular subtypes" refers to different categories or groups within a larger group of molecules (such as genes or proteins) that exhibit distinct characteristics or behaviors. These subtypes help scientists better understand and categorize the molecules based on their specific traits, allowing them to identify patterns or differences among them.
Full definition
Her current research projects include informatics methods for 1) clinical decision support for treatment prioritization of
molecular subtypes of cancer, 2) longitudinal clinical plan management, 3) data analytics, and 4) learning cancer systems.
In all, there were 291 tumors with KRAS, 393 with NRAS, 393 with BRAF, 378 with microsatellite instability, and 533 with
consensus molecular subtypes.
The researchers report in Neuron that serotonergic neurons come in at least six
major molecular subtypes defined by distinct expression patterns of hundreds of genes.
Patients will receive rapid molecular testing and will be assigned an intravenous or oral therapy based on their
AML molecular subtype.
Colorectal cancer cell lines are representative models of the
main molecular subtypes of primary cancer.Cancer Res.
Broeks et al analyzed gene expression profile data to query whether differences in
molecular subtype exist between sporadic breast cancers and breast cancers associated 1with RT exposure.
Currently researchers are looking at
possible molecular subtypes of the disease, but for now we know that there are 33 locations on the chromosome of the Greyhound that could potentially activate hereditable OS.
The prognosis for anyone diagnosed with lymphoma varies widely depending on
which molecular subtype of the disease they have, so gaining a better understanding of those subtypes is vital to developing better therapies.
The primary tumor location was an independent prognostic marker in patients with RAS wild - type metastatic colorectal cancer after adjusting for age, gender, synchronous / metachronous disease,
consensus molecular subtype, and microsatellite instability and molecular status, according to the results of an analysis (abstract 3503) of data from CALGB / SWOG 80405 presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting.
This finding allowed their team to classify tumors into four
major molecular subtypes, which could also lead to developing new therapies.
Our efforts on this front have resulted in the establishment and validation of four
molecular subtypes of colorectal cancers.
The EPIC cohort study consisted of 337,327 women living in 10 European countries, which creates a heterogeneous cohort both in terms of geography - related dietary fat intake patterns and in terms of
molecular subtype.
A clinical trial has shown that patients with a specific
molecular subtype of diffuse large B - cell lymphoma (DLBCL) are more likely to respond to the drug ibrutinib (Imbruvica) than patients with another molecular subtype of the disease.
Research physicians will measure the effectiveness of rapid genomic AML screening followed by assignment to novel molecular - targeted and immunologic therapies tailored to a patient's
molecular subtype.
In this updated multivariable analysis, the researchers included age, race, gender, synchronous vs metachronous disease, and consensus
molecular subtypes, as well as other mutational events such as BRAF, NRAS, KRAS, HRAS, and microsatellite instability status.
Hirshfield KM, Ganesan S. Triple - negative breast cancer:
molecular subtypes and targeted therapy.
Study 1, led by researchers in Germany, systematically analyzed 961 tumors representing 24
molecular subtypes of pediatric cancer, including 547 whole genome sequences (~ 37x coverage genome - wide) and 414 whole - exome sequences (~ 121x coverage of coding regions only).
As part of the colorectal cancer subtyping consortium, our Moon Shot ™ experts used cutting - edge molecular, biological and «big data» approaches to define four
molecular subtypes of colorectal cancer, which now guide our efforts to develop non-invasive diagnostic tests and new treatment approaches.
MD Anderson researchers helped lead an international collaboration that defined four different
molecular subtypes of this disease.
These molecular subtypes have recently been confirmed in a comprehensive characterization of human breast tumors at the genomic, epigenetic, transcriptomic, and proteomic levels (Cancer Genome Atlas Network, 2012).
Before starting her consulting business, Be Well By Kelly, she worked in the medical field for Fortune 500 companies like J&J, Stryker, and Hologic, eventually moving into personalized medicine, offering tumor gene mapping and
molecular subtyping to oncologists.