Sentences with phrase «molecular switching mechanisms»
Instead of addiction being a chronic, permanent disease, recent evidence is showing that addiction is controlled by molecular switching mechanisms in the brain, that can be turned on or off with the right interventions» says Dr. Steven Laviolette.
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Similar to capsaicin, tumor necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor necrosis factor (50).
Researchers believe cells developed the affinity switch mechanism for proteasomes to prevent incomplete and faulty pieces from being put together to assemble these «molecular machines.»
And their detailed understanding of the underlying reaction mechanism should enable the LMU researchers to apply this relatively simple way of controlling molecular motions to other types of chemical switches.
«We have understood the mechanism of this molecular switch and, consequently, many wonderful possibilities are opening up for us,» says project group leader Astrid Mach - Aigner.
Principal Investigators Sebastian Deindl (Uppsala University / SciLifeLab) and Simon Boulton (Francis Crick Institute) together with their teams shed light on the molecular mechanisms that switch on and off the oncogenic chromatin remodeling enzyme ALC1 (short for Amplified in Liver Cancer 1).
Understanding the underlying mechanisms allows identifying putative sites for pharmacological intervention and opens the prospect of engineering artificial molecular switches derived from the highly efficient systems that have evolved for cellular signal transduction.
Hunter is known for his 1979 discovery of a mechanism called tyrosine phosphorylation, which is a molecular switch that turns normal cells cancerous.
After a two - year stint as a postdoctoral research fellow in Pharmacology in the laboratory of Dawn Quelle at the University of Iowa, where I studied the molecular mechanisms of tumorigenesis, I made the switch to industry.