Sentences with phrase «molecule drugs designed»

Other companies, including the Swiss drug giants Novartis and Roche, along with Boston's Paratek Pharmaceuticals, are developing ingestible small - molecule drugs designed to increase the inclusion of SMN2 «s exon 7.

«They also provide a promising strategy for identifying small molecule drugs designed to treat Alzheimer's disease and other neurological disorders.»

Not exact matches

In December, Tehrani signed a deal with GlaxoSmithKline that will allow the pharmaceutical giant to test at least four of its drug candidates on a Zymeworks - designed platform, which combines a computer simulation with a way of engineering protein molecules and allows products to be refined before they move to expensive clinical trials.

What Boger wants is to create a better way to develop drugs: through a process called structure - based design in which scientists build up a new drug, atom by atom, after determining the type of molecule that might interrupt the disease process.

Why it matters: Understanding molecules in exact detail will allow chemists to design more effective drugs and better materials for generating and distributing energy.

«We could apply the strategy used in this study to quickly identify and design small molecule drugs for other RNA - associated diseases,» explained study first author Sai Velagapudi, a research associate in the Disney lab.

Dr Baker explained: «Our work has implications not only for understanding the basic science of protein folding and stability, but also for guiding the design and engineering of new proteins and drug molecules.»

Lawrence Goldstein and his colleagues at the University of California, San Diego (UCSD), reasoned that if they could find a molecule that halts kinesin function, they could learn more about when and how they work — and possibly design drugs to disable specific kinesins.

This open layout means that Bio21 students, primarily graduate students and postdocs, are assured of opportunities to interact with researchers from a variety of disciplines; a biochemistry student, for example, has the opportunity to work — and chat — with chemists who are designing molecules for potential drugs, or geneticists, or pharmacologists.

The researchers designed a molecule combining 7,8 - dihydroxyflavone, which mimics a protein critical for development and function of the nervous system, and bisphosphonate, a type of drug that sticks to bones.

Much research is trying to design drug molecules able to cross such barriers, which can act as very specific filters.

The researchers targeted mTOR with an experimental drug based on a prototype first designed by Shokat, a chemist and an expert in designing molecules to target this type of protein, called a kinase.

A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat the most frequent and lethal form of brain cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

It streamlines the process of designing molecules for uses in new drugs, industrial chemicals and new materials.»

These new nanoparticles are equipped with specially designed nanovalves that can control release of anticancer drugs from thousands of pores, or tiny tubes, which hold molecules of chemotherapy drugs within them.

A specially designed chiral catalyst is used to oxidize hydrocarbons into multifunctional compounds that are obtained in high purity and are readily converted into an assortment of molecules that will streamline the synthesis of future pharmaceutical drugs,» said Dr. Leila Bayeh, a former graduate student and lead author of the study.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

Cosa's research group specializes in single - molecule fluorescence techniques, while Sleiman's uses DNA chemistry to design new materials for drug delivery and diagnostic tools.

Small molecule drugs can be screened or designed to increase telomerase activity exclusively within stem cells for disease treatment as well as anti-aging therapies without increasing the risk of cancer.

Ultimately, the researchers hope it might be possible to design a drug that delivers both antibacterial agents and decoy molecules.

A team of researchers led by biophysicists at the University of Washington have come one step closer to designing tailor - made drug molecules that are more precise and carry fewer side effects than most existing therapeutic compounds.

King said he looks forward to a time when cancer - drug molecules will be packaged inside of designed nanocages and delivered directly to tumor cells, sparing healthy cells.

The experimental research, conducted by Griffith University's Centre for Quantum Dynamics, aims to help in the design of new molecules for materials science or drug discovery.

Determining the similarities of molecular structures now plays an important role in designing all kinds of new molecules — mainly drugs, but also pesticides, fuels, polymers and substitutes for blood and other body fluids.

Anderson and Valerie Grum - Tokars, a junior structural biologist on the team, developed a three - dimensional structure of human p38 MAPK, enabling the chemists to design and synthesize novel drug - like small molecules that would disable it.

If it can learn to predict something else, such as how well a molecule binds to an enzyme, it could help with designing drugs, fuel cells, batteries or biosensors.

The ProVision 100 is a computer system with software which converts data such as simulations of drug molecules or architects» designs from a two - dimensional format into three dimensions.

Prof. Joost Schymkowitz and Prof. Frederic Rousseau of VIB - KU Leuven in collaboration with Prof. Johan Van Eldere of University Hospitals Leuven have gone one step further: they have developed a new way of designing antibiotic drugs that can give rise to many new antibacterial molecules.

Dr Emma Smith, senior science communications officer at Cancer Research UK, said: «Revealing the molecule's detailed shape could be the first step towards designing more precise drugs to block it.

The research could help other scientists to use cryo - EM in structure - based drug design studies — in which researchers build the best possible drugs starting from a molecule which already binds to the active site of a target protein.

This unusual binding mechanism opens a new avenue for drug design: Scientists can consider less rigid protein targets and identify molecules that stabilize more mobile forms of the protein upon binding — somewhat like a ski boot with an adaptable inner liner that continually adjusts to the foot.

To combat this problem, the Wyss team rationally designed a more effective, multi-part drug molecule.

The findings, published online October 10 in the Cell Press journal Cell Metabolism, may be useful for designing drugs that utilize this exercise - induced molecule to guard against neurodegenerative diseases and improve cognition in the aging population.

In theory, quantum computers would allow hackers to crack today's toughest coded messages and researchers to better simulate molecules for designing new drugs and materials.

«If the molecule shows equal efficacy and safety in humans, then this particular «smart» drug design may indeed offer perspectives for metabolic precision medicine,» summarizes Tschöp.

A powerful new way of analysing how drugs interact with molecules in the body could aid the design of better treatments with fewer side - effects.

To harness this system for the destruction of cancer proteins, Bradner's team designed a chemical adapter that attaches to a targeted drug molecule.

Now the precise structure of the pyripyropenes is known, chemists should be able to design similar molecules that may be even more effective at blocking ACAT and form the basis of drugs to treat atherosclerosis.

«This is the first instance I am aware of where an academic drug discovery group moved a molecule designed to hopefully treat a chronic brain disorder all the way from early discovery to human trials without there being, at some point along the way, a pharmaceutical partner,» said P. Jeffrey Conn, Ph.D., Lee E. Limbird Professor of Pharmacology in the Vanderbilt University School of Medicine and director of the Vanderbilt Center for Neuroscience Drug Discovery (VCNdrug discovery group moved a molecule designed to hopefully treat a chronic brain disorder all the way from early discovery to human trials without there being, at some point along the way, a pharmaceutical partner,» said P. Jeffrey Conn, Ph.D., Lee E. Limbird Professor of Pharmacology in the Vanderbilt University School of Medicine and director of the Vanderbilt Center for Neuroscience Drug Discovery (VCNDrug Discovery (VCNDD).

By combining quantum and classical mechanics, three researchers could model how electrons jump between elements in a molecule, enabling a deeper understanding of reactions and the design of new drugs

Published in Angewandte Chemie International Edition, the study combines uniquely designed molecules and light - dependent drug release, which may provide a new platform to enhance the effect of anticancer therapeutics.

The molecular models arising from their work can be used to design new drugs that interact with critical regions on the tau molecule to prevent its assembly into tangles.

Typical nanoparticle designs don't allow for scaling, since they call for building a nanoparticle first and then encapsulating the drug molecules within it, or chemically attaching the molecules to the nanoparticle.

Professors Coombes and Ali suggested CDK7 as a drug target, leading the collaboration to attempt to design a molecule that would inhibit its action.

By understanding the details of this motion, one can determine the amount of energy needed to transform reactants into products in a chemical reaction, or the color of light absorbed by a molecule, and ultimately accelerate the design of new drugs and materials, better catalysts and more efficient energy sources.

An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.

The SMDC has allowed Gladstone scientists to design molecules to modulate the functions of proteins or specific cellular phenotypes and, most significantly, screen for drugs that could be used as therapies for disease.

The Unit's scientific mission covers the design, synthesis, molecular modeling, as well as biophysical, biochemical and cellular studies of small - molecule probes and drug candidates targeting nucleic acids or proteins involved in cancer.

rational drug design: which involves designing and synthesising compounds based on the known structure of a specific target molecule.

Further the Meiler laboratory develops a structure - based drug design module for ROSETTA and docking protocols particularly suited for docking small molecules into comparative models.