Sentences with phrase «molecule lead compounds»

Not exact matches

To try to develop a more sensitive probe for isolating individual peptides — short strands of amino acids — from a pool of similar molecules, a team led by chemist Clark Still of Columbia University 4 years ago synthesized small organic compounds that selectively fish out peptides dissolved in chloroform.

A team led by Stuart Licht at the Technion - Israel Institute of Technology in Haifa has come up with a new cathode made from unusual iron - based molecules — iron (VI), or «super-iron,» compounds — that absorb more electrons than manganese dioxide.

Cyanide compounds are very reactive, so reactions on early Earth could have led to the more complex organic molecules that life needed (Geophysical Research Letters, DOI: 10.1029 / 2009gl040252).

Volcanic plumes were ideal crucibles for sparking stable nitrogen to form reactive compounds that led to the first organic molecules, chemists report in the 15 August Geophysical Research Letters.

A specially designed chiral catalyst is used to oxidize hydrocarbons into multifunctional compounds that are obtained in high purity and are readily converted into an assortment of molecules that will streamline the synthesis of future pharmaceutical drugs,» said Dr. Leila Bayeh, a former graduate student and lead author of the study.

«We've provided the first solid fundamental data on these compounds,» said Berry, who led the effort to synthesize the stable version of a normally short - lived molecule.

A team of researchers led by biophysicists at the University of Washington have come one step closer to designing tailor - made drug molecules that are more precise and carry fewer side effects than most existing therapeutic compounds.

University of Illinois chemist Martin Burke, a pioneer of a technique that constructs complex molecules from simple chemical «building blocks,» led a group that found that thousands of compounds in a class of molecules called polyenes — many of which have great potential as drugs — can be built simply and economically from a scant one dozen different building blocks.

Based on a plant - based class of molecules known as indoline alkaloids, the compound inhibits an enzyme called polymerase, which enables a virus to make thousands of copies of itself and cause disease, explains Claire Marie Filone, the study's lead author.

«It never ceases to amaze me how a simple molecule, such as saccharin — something many people put in their coffee everyday — may have untapped uses, including as a possible lead compound to target aggressive cancers,» says Robert McKenna, Ph.D., who is at the University of Florida.

The initial work identified the precursor to GS - 5734, a small - molecule antiviral agent, which led to the effort by Gilead and USAMRIID to further refine, develop and evaluate the compound.

In order to prioritize these hits compounds for the development of probe or lead molecules it is critical to determine their mode of action, i.e. the biological target protein.

Currently, Everon is optimizing several lead compounds: small molecules and biologics that have already demonstrated a rejuvenation effect in aging animals, as measured by a lowered mouse FI (similar FI has recently been accepted by FDA as a measure of aging in the ongoing Metformin human trial).

«Unfortunately, this compound was rather toxic, which led me to think more about the safety of molecules.

But for people with type 2 or type 3 SMA, «the reality is that any sort of treatment would be a blessing,» says Jill Jarecki, research director of Families of SMA who, in a previous job, led the small - molecule screening effort that yielded RG3039, the Repligen compound.

We are pursuing both goals by studying the underlying biology, defining therapeutic targets, identifying active molecules by high - throughput screening and developing lead compounds.

The functional disruption leads to oxidative stress inside the cell; an accumulation of highly reactive oxygen compounds takes place and a large number of the cell's molecules are damaged.