Sentences with phrase «molecule library screen»

Not exact matches

David Sinclair of Harvard Medical School in Boston and colleagues at the biotech firm BIOMOL Research Laboratories in Plymouth Meeting, Pennsylvania, screened a library of compounds for molecules that trigger SIRT1 activity.

In this study, the researchers screened a library of 200,000 small molecule compounds to identify potential inhibitors of Ebola virus RNA synthesis.

Today, the pharmaceutical industry screens synthetic chemical libraries of thousands of molecules to find one that may have a medicinal effect, said Parekkadan, who joined Rutgers» School of Engineering in January.

In one case, the researchers screened a small - molecule compound library and identified compounds that bind tightly to NUCB1, an otherwise little - known protein that showed strong interactions with the arachidonoyl probes.

They identified AM404 as a potential antiviral agent by screening the National Institutes of Health Clinical Collection, a library of small molecules that have been used clinically in humans, using a high - throughput screening system.

Nikolas Jorstad and Matt Wilken, graduate students in Reh's lab, screened a library of small molecules to find one that could reopen access to the genetic code in the adult mouse.

To test DDX3's druggability, the team chose to design its own small molecule rather than screen libraries of molecules already created.

The process of drug discovery has been dominated in recent years by the screening of large libraries of structurally diverse small molecules for effects on target proteins associated with disease.

Such projects involve developing and optimizing assays for automation, screening a large compound library, and characterizing each small - molecule probe.

We are going to screen a larger library of chemicals to identify molecules that either boost or weaken NMD, which should help develop better and more targeted drugs for treating ALS, muscular dystrophy and cystic fibrosis.»

Scientists at the Centers for Disease Control and Prevention (CDC) also contributed by performing initial screening of the Gilead Sciences compound library to find molecules with promising antiviral activity.

«We're now working with our colleagues in Sanford - Burnham's Conrad Prebys Center for Chemical Genomics to screen a large chemical library — a collection of around 300,000 compounds — to find molecules that bind to these newly discovered HNF - 4α sites,» Rastinejad said.

The MSC is a core facility providing the use of high throughput screening technology (HTS), as well as expertise and reagents, necessary for the screening of the library of small molecules for biologically active compounds in a variety of readout systems.

The facility maintains a small molecule library of ~ 100,000 drug - like small molecules for high - throughput screening and provides access to liquid handling robotics and a multilabel plate reader.

Our current works have focused on screening the chemical libraries to identify and further characterize small molecules that can control stem cell fate in various systems.

UniChem supports the integration of high - throughput screening data on small molecules with chemical libraries and chemical resources for drug discovery and optimization.

The course gives a broad introduction to high throughput screening (HTS) that is technique used to identify biologically active small organic molecules through screening of compound libraries with the help of robust test systems and advanced instrumentation.

The identification of disease signatures will enable screens of small molecule libraries to delineate molecular targets that modulate these disease signatures and identify new diagnostic and therapeutic leads for schizophrenia and bipolar disorder.

With Jan Stichel at Annette Beck - Sickinger's lab, Leipzig University, Germany and David Weaver, head of the high - throughput screening facilities at Vanderbilt University, I will be screening Vanderbilt's library of small molecules for potential allosteric modulators of the human Y4 receptor.

Another key contribution made to the field is Schreiber's formal planning of diversity - oriented synthesis (DOS), which involves the creation of diverse libraries of small molecules for biological screening.

Once the Vanderbilt small molecule library has been screened for potential modulators of the Y4 receptor, I will use the results to design efficient and accurate descriptors that can be used with artificial neural networks to predict activity at the Y4 receptor based on a small molecule's structural properties.

Using this information, we will then take advantage of recent advances in the quantification of assembly to screen candidate small - molecule libraries for enhanced activity in assembly acceleration, inhibition, and misdirection.

Phenotypic screening of small molecule libraries using iPSC - based models to identify novel drug candidates and disease mechanisms.

The team screened a small molecule compound library and identify a drug, which they call CLP257.