Background: Oxford Nanopore Technologies Ltd (Oxford, UK) have recently commercialized MinION, a small single -
molecule nanopore sequencer, that offers the possibility of sequencing long DNA fragments from small genomes in a matter of seconds.
A reference bacterial genome dataset generated on the MinION ™ portable single -
molecule nanopore sequencer
Not exact matches
• Oxford
Nanopore Technologies Ltd, a U.K. - based developer of nanopore - based electronic systems for analysis of single molecules, raised $ 100 million pounds ($ 140 m
Nanopore Technologies Ltd, a U.K. - based developer of
nanopore - based electronic systems for analysis of single molecules, raised $ 100 million pounds ($ 140 m
nanopore - based electronic systems for analysis of single
molecules, raised $ 100 million pounds ($ 140 million).
Researchers, including Karnik's group, have developed techniques to fabricate graphene membranes and precisely riddle them with tiny holes, or
nanopores, the size of which can be tailored to filter out specific
molecules.
UK - based Oxford
Nanopore Technologies published a report last year showing that it could detect methylated DNA at a single -
molecule level.
Nanopores are miniscule holes (often as small as a few billionths of a meter) that measure a change in electrical current as
molecules pass through them.
Now, a team led by University of Pennsylvania physicists has used solid - state
nanopores to differentiate single - stranded DNA
molecules containing sequences of a single repeating base.
Background The MinION ™ is a new, portable single -
molecule sequencer developed by Oxford
Nanopore Technologies.
The audience fidgeted with eager impatience to hear Clive Brown of Oxford
Nanopore present an update on their single -
molecule, real - time sequencing technology.
Early MinION ™
nanopore single -
molecule sequencing technology enables the characterization of hepatitis B virus genetic complexity in clinical samples — Virginie Sauvage — PLOS ONE
Scott D. Collins, Ph.D., University of Maine, Orono $ 850,000 (2 years) «High - speed
Nanopore Gene Sequencing» Skilled in silicon fabrication methods, this group will try to fabricate a nanopore with tiny electrodes and built - in circuits that will be used in experiments that attempt to measure differences in the electron tunneling of individual nucleotides in DNA mo
Nanopore Gene Sequencing» Skilled in silicon fabrication methods, this group will try to fabricate a
nanopore with tiny electrodes and built - in circuits that will be used in experiments that attempt to measure differences in the electron tunneling of individual nucleotides in DNA mo
nanopore with tiny electrodes and built - in circuits that will be used in experiments that attempt to measure differences in the electron tunneling of individual nucleotides in DNA
molecules.
Andre Marziali, Ph.D., University of British Columbia, Vancouver $ 650,000 (3 years) «
Nanopores for Trans - Membrane Bio-Molecule Detection» This group will contribute to understanding how single biological
molecules interact with pores inserted into membranes, and how useful information can be derived from those interactions.
New generation of sequencing technology uses
nanopores to deliver ultra long read length single
molecule sequence data, at competitive accuracy, on scalable electronic GridION platform.
The design and engineering of advanced solid - state
nanopore materials could allow for the development of novel gene sequencing technologies that enable single -
molecule detection at low cost and high speed with minimal sample preparation and instrumentation.
Sequencing the gigabase plant genome of the wild tomato species Solanum pennellii using Oxford
Nanopore single
molecule sequencing
Motivation: Single
Molecule Real - Time (SMRT) sequencing technology and Oxford
Nanopore technologies (ONT) produce reads over 10kbp in length, which have enabled high - quality genome assembly at an affordable cost.
Nanopore sequencing is a promising technique for genome sequencing due to its portability, ability to sequence long reads from single
molecules, and to simultaneously assay DNA methylation.
Nanopore - based single
molecule sequencing of the D4Z4 array responsible for facioscapulohumeral muscular dystrophy
The Oxford
Nanopore MinION is a portable single -
molecule DNA sequencer that can sequence long fragments of genomic DNA.
The Oxford
Nanopore Technologies (ONT) MinION is a new sequencing technology that potentially offers read lengths of tens of kilobases (kb) limited only by the length of DNA
molecules presented to it.
The MinION is a portable device that uses
nanopore technology and can sequence long DNA
molecules.
An obstacle to realizing this promise is delivering ultra-long DNA
molecules to the
nanopores.
The MinION is a portable single -
molecule DNA sequencing instrument that was released by Oxford
Nanopore Technologies in 2014, producing long sequencing reads by measuring changes in ionic flow when single - stranded DNA
molecules translocate through the pores.
Motivation:
Nanopore sequencing may be the next disruptive technology in genomics, due to its ability to detect single DNA
molecules without prior amplification, lack of reliance on expensive optical components, and the ability to sequence very long fragments.