Not exact matches
One of the team's new biosensors is made from a nanoplasmonic material that is able to accommodate a large number of
cells on a single substrate and to
monitor cell proliferation, a fundamental process involving
cell growth and
division, in real time.
By measuring how the light has changed once it emerges through the other side of the slide, the researchers can detect and
monitor processes occurring on the sensor surface, such as
cell division.
The assay uses time - lapse microscopy to
monitor individual yeast
cells undergoing a small number of
divisions to form microcolonies.
«Many
cell types have been shown to reach a size threshold before they commit to
cell division and this requires that they somehow
monitor their own size,» says Professor Martin Howard from the John Innes Centre.
Researchers at Johns Hopkins recently learned that most
cells will not divide without centrioles, and they found out why: A protein called p53, already known to prevent
cell division for other reasons, also
monitors centriole numbers to prevent potentially disastrous
cell divisions.
«P53 was already known to
monitor many things, like DNA damage and having the wrong number of chromosomes, that make
division dangerous for
cells,» says Andrew Holland, Ph.D., an assistant professor of molecular biology and genetics at the Johns Hopkins University School of Medicine.
The eggs are
monitored to confirm that fertilization and
cell division are taking place.
For endodermal
cells, a window of 20 — 65 non-dorsal sox17: eGFP +
cells were
monitored for
cell divisions from the onset of GFP expression to approximately 85 % epiboly in three time windows to allow for correction of focus (20 frames, 54 frames, 20 frames, respectively).