The x-ray crystallographer at the Scripps Research Institute in San Diego, California, is leading an international effort to develop a potent mix of
monoclonal antibodies against the virus, some of which have already shown promise in animals.
Not exact matches
Data from in vivo mouse models indicate that delivery of the DMAb sequence for the influenza A-targeted
monoclonal antibody protected
against lethal doses of two very different, clinically relevant influenza A
viruses.
For example, the most advanced therapy — ZMappTM, a cocktail of three
monoclonal antibodies — is specific for Ebola
virus (formerly known as «Ebola Zaire»), but doesn't work
against two related ebolaviruses (Sudan
virus and Bundibugyo
virus) that have also caused major outbreaks.
ASU researchers Qiang «Shawn» Chen and Huafang «Lily» Lai infiltrate a tobacco plant to produce
monoclonal antibodies against West Nile
virus.
The study, «Dengue
Virus Envelope Dimer Epitope
Monoclonal Antibodies Isolated from Dengue Patients Are Protective
against Zika
Virus,» was published in the July / August issue of mBio, the journal of the American Society for Microbiology.