I use this test most frequently on those with one or
more MTHFR mutations.
Not exact matches
Those with the
MTHFR gene can have impaired detoxification so I'm very careful aboutRead
More →...
A total of 150 women with a history of two or
more recurrent miscarriages and 20 fertile control women with no history of pregnancy losses had buccal swabs taken for DNA analyses of 10 gene mutations [factor V G1691A, factor V H1299R (R2), factor V Y1702C, factor II prothrombin G20210A, factor XIII V34L, beta - fibrinogen -455 G > A, PAI - 1 4G / 5G, HPA1 a / b (L33P),
MTHFR C677T,
MTHFR A1298C].
This conversation covers all of that and so much
more, including: metabolic typing, preconception nutrition, genetics, defining methylation, and the much talked about
MTHFR mutation.
If you'd like to learn
more on this subject, I've put together a beginner's guide to
MTHFR here, and a FAQ page here.
To make matters
more complicated, about 50 % of the population is estimated to have at least one mutation at the
MTHFR gene and 10 % has two mutations, meaning they're less able to methylate B12 or convert cyanocobalamin to methylcobalamin.
Individuals without dietary restrictions or
MTHFR mutations can simply consume
more meat, fish, poultry, and eggs in their diets.
Those with a defective
MTHFR gene have an impaired ability to produce the
MTHFR enzyme (estimates range from 20 % -70 % or
more).
If you are new to
MTHFR and feel overwhelmed like I did, here are some great resources for
more reading:
The
more mutations you have to the
MTHFR gene the less able you are to methylate and detoxify toxins, such as mercury and lead.
The cost is $ 199, and you get
more information than just
MTHFR status.
You can find
more information about
MTHFR gene mutation at: http://ghr.nlm.nih.gov/gene/
MTHFR http://www.stopthethyroidmadness.com/
mthfr/ http://
mthfr.net/
homocystiene, methylation and
MTHFR mutation How does this relate to
MTHFR mutation; for example heterozygous C677T, where methylation proceeds much
more inefficiently than in folks with homozygous C?
Problem is, nearly half (if not
more) of U.S. women have some sort of
MTHFR mutation, which means they can not properly digest folic acid.
Here, I'd like to chip away at one small piece of the puzzle that I have not written about yet: why benefits from SAMe supplementation should cause one to look not only at the most commonly discussed methylation nutrients (e.g., B12, folate, choline, betaine, methionine) and genetic polymorphisms (e.g.,
MTHFR) but also at issues that are
more commonly neglected when discussing methylation: magnesium and the metabolic rate.
MTHFR is associated with folate
more than anything.
According to research,
more than half the general population has some type of
MTHFR mutation.
I have been starting to learn
more about
MTHFR.
Again, all the latter is simplified and you will need to seek
more detailed information from a qualified practitioner or even some of the excellent website and forums on
MTHFR.
NOTE FROM JANIE BOWTHORPE: I have one copy of the 1298
MTHFR mutation and never had a problem, until the stress of mold exposure followed by having to detox high copper seemed to make it come alive, along with mutations with COMT, MTRR and
more.
So the short answer to your question is no, you can not compensate for an
MTHFR gene variant by taking
more folate in your diet.
Having
MTHFR issues makes it
more difficult for the body to detoxify.
Read
more about
MTHFR and the proven workarounds in my new book, Younger: A Breakthrough Program to Reset Your Genes, Reverse Aging, and Turn Back the Clock 10 Years.
Go to
MTHFR support.net for
more info.