Sentences with phrase «more aggressive breast cancer»

«We found that PIM1 is indeed highly upregulated in these more aggressive breast cancers that have high MYC expression,» Goga said, «and that patients with high PIM1 tend to do more poorly.»

Not exact matches

«Our discovery of these mutations is a first step in developing a genetics - based system for classifying endometriosis so that clinicians can sort out which forms of the disorder may need more aggressive treatment and which may not,» says Ie - Ming Shih, M.D., Ph.D., the Richard W. TeLinde Distinguished Professor in the Department of Gynecology & Obstetrics at the Johns Hopkins University School of Medicine and co-director of the Breast and Ovarian Cancer Program at the Johns Hopkins Kimmel Cancer Center.

Triple - negative tumors are aggressive and more likely to metastasize than other breast cancers, and there is no effective treatment.

PARP inhibitors have shown efficacy for a small group of patients with breast cancer with inherited mutations in BRCA genes, but have failed in the more aggressive triple - negative disease.

Extensive studies have found that 20 % to 30 % of breast cancers are characterized by over-expression of HER2, which makes the cancer cells grow and divide faster, leading to a cancer that's more aggressive and more likely to be resistant to the standard of care.

Women who have a genetic mutation face a higher risk of developing a second breast cancer and may wish to consider more aggressive treatment, preventive measures or additional screening.

Recent studies have shown an increase in women with breast cancer choosing this more aggressive surgery, called contralateral prophylactic mastectomy, which raises the question of potential overtreatment among these patients.

Women who pursue a more aggressive surgery for early stage breast cancer have nearly eight times the odds of reporting substantial employment disruptions, according to a new study from University of Michigan Comprehensive Cancer Center researcancer have nearly eight times the odds of reporting substantial employment disruptions, according to a new study from University of Michigan Comprehensive Cancer Center researCancer Center researchers.

The study, which will be published December 21 in the Journal of Cell Biology, suggests that the loss of these particular Numb proteins makes breast cancers more aggressive and resistant to chemotherapy, but points the way toward new therapeutic approaches that could improve patient outcome by preserving p53 levels.

«Double mastectomy tied to more missed work: As more breast cancer patients are choosing to remove both breasts, researchers examine the impact this aggressive surgery has on their employment.»

The old idea that cancer is less aggressive in the elderly is not entirely without merit: breast and prostate cancers tend to grow more slowly in older patients.

A new study finds that more than half of women with early stage breast cancer considered an aggressive type of surgery to remove both breasts.

Although prolonged breastfeeding reduces overall cancer risk, women have an increased risk of developing breast cancer for the first 5 to 10 years following pregnancy, and these cancers tend to be more aggressive.

Researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread.

It has been recognized that the more aggressive triple - negative breast cancer occurs more frequently in African American women, but no previous study has examined racial differences in tumor genotype and how they might contribute to the risk of cancer recurrence.

«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the Cancer Center, lead author of the study.

Although breast cancer is somewhat more aggressive in South Asian and Black women than in White women, this is largely due to age differences between ethnic groups in the UK, according to new research.

The results suggest that the pockets of stiffer extracellular matrix in the breasts of obese women contribute to tumor growth as well as to more aggressive cancers, Fischbach says: «People always think it's all about soluble factors, chemicals.

Compared to other types of breast cancer, triple negative breast cancers are often more aggressive and have fewer treatment options.

«Triple - negative breast cancers tend to be more aggressive compared to other types of breast cancers, and being able to predict response to therapy could greatly impact treatment decisions and patient outcomes,» says study author Shaveta Vinayak, MD, oncologist at UH Case Medical Center and Assistant Professor at Case Western Reserve University School of Medicine.

Like pervasive hypertension, some cancers, such as prostate and breast, tend to occur earlier and be more aggressive in blacks than whites, said Dr. Edward J. Kruse, chief of surgical oncology at MCG and the Georgia Cancer Center.

If validated in larger studies, this breakthrough could mean that it may be possible to identify those at the highest risk of their breast cancer spreading, with more aggressive treatments targeted specifically to them, while those at low risk could be spared treatments that may not benefit them, as well as the subsequent side - effects.

The researchers found that non-Hispanic white women were more likely to have smaller tumors, and more likely to have the less - aggressive HR + / HER2 - subtype of breast cancer, compared with African - American women, who were more likely to have large tumors, more likely to have the aggressive triple - negative breast cancer, and 40 to 70 percent more likely to be diagnosed at stage 4 of all subtypes of breast cancer.

The rigidity actually makes breast cancer turn more aggressive.

The researchers found that minority women are more likely to have aggressive subtypes of breast cancer and were less likely to receive guidelines - based standard of care as compared to non-Hispanic white women.

A new score that could identify certain women with primary breast cancer in need of more or less aggressive treatments could play a pivotal role in ensuring they are given the best possible chance of survival, while only giving treatments such as chemotherapy when it's necessary.

It's the aggressive, triple - negative basal - like breast cancer that seems to be reduced by breastfeeding more so than is ER / PR positive breast cancer, which is more treatable.

These breast cancers tend to be more aggressive, with greater frequency of hormone receptor negativity and potential HER2 positivity.

African American women are more often diagnosed with aggressive, late - stage breast cancers — resulting in mortality rates that are 44 % higher than for Caucasian women.

And a study released in March 2008 by researchers at the University of Texas M.D. Anderson Cancer Center in Houston showed that obese and overweight women also had lower breast cancer survival rates and a greater chance of more aggressive disease than average - weight or underweight Cancer Center in Houston showed that obese and overweight women also had lower breast cancer survival rates and a greater chance of more aggressive disease than average - weight or underweight cancer survival rates and a greater chance of more aggressive disease than average - weight or underweight women.

It is also important to note that inflammatory breast cancer is much more aggressive than the other types of invasive breast cancers we have discussed, including both invasive ductal carcinoma and invasive lobular carcinoma.