Sentences with phrase «more aggressive disease»

Young dogs with osteosarcoma tend to have shorter survival times and more aggressive disease than older dogs with osteosarcoma.

And a study released in March 2008 by researchers at the University of Texas M.D. Anderson Cancer Center in Houston showed that obese and overweight women also had lower breast cancer survival rates and a greater chance of more aggressive disease than average - weight or underweight women.

In patients with lung cancer, higher levels of HGF may indicate more aggressive disease.

Differently from all other proteins in this class, survivin is selectively over-expressed in virtually every human cancer where it signals more aggressive disease and unfavorable outcome.

Mutations in the beta - catenin gene, or flaws in the factors that degrade it, have long been linked to more aggressive disease in various tumor types, including colon, lung and prostate cancer, and melanoma.

Unfortunately, doctors currently have no reliable way of predicting which men will develop evidence of worsening or more aggressive disease during active surveillance.

After following 154 men with low - risk prostate cancer for 38 months, the investigators found that low levels of free testosterone were significantly linked with an increased risk of developing more aggressive disease.

Hypoxia, or a lack of oxygen, is one example of a phenomenon that should weaken the tumor, but instead, the malignant cells are able to compensate and drive more aggressive disease behavior.

«Metastatic prostate cancer cases skyrocket: More lax screening rather than more aggressive disease?.»

«The fact that men in 2013 who presented with metastatic disease had much higher PSAs than similar men in 2004 hints that more aggressive disease is on the rise,» Schaeffer said.

The researchers also reasoned that if erectile dysfunction medications cause melanoma, they would expect to find more aggressive disease among people who take the medications, but that was not the case.

«Once they block this first pathway, then other pathways can get activated, leading to an even more aggressive disease.»

Not exact matches

The unaware mothers also reported more aggressive behavior, sleep problems, and child anxiety and depression than mothers who knew that their children had celiac disease.

Mothers of 66 children who had celiac disease but didn't know it yet reported more child anxiety and depression, withdrawn behavior, aggressive behavior, and sleep problems when compared to the more than 3,651 mothers of children who did not have celiac disease at all.

BOSTON (AP)-- A new report is urging Massachusetts officials take more drastic steps to combat Lyme disease, from launching aggressive public education campaigns to exploring expanded crossbow hunting to cut down on the number of deer that may be carrying ticks.

We are concerned also that intensive harvesting for fuel will lead to more aggressive clear - cutting and to increases in emissions of soot particles that contribute to lung disease.»

Prof. Severine Vermeire (KU Leuven / UZ Leuven): «In the future, gut bacteria may be used to help identify PSC patients with a more or less aggressive disease, or patients that may benefit from microbiota - based therapies, such as fecal microbiota transplantation or targeted pre - and probiotics.»

He says a molecular test that sorts lesions as more or less aggressive has the potential to help doctors and patients decide how to treat and monitor the progression and control of the disease.

PARP inhibitors have shown efficacy for a small group of patients with breast cancer with inherited mutations in BRCA genes, but have failed in the more aggressive triple - negative disease.

Women with the variant were at much higher risk for cancer, had more recurrences, were often hit with multiple cancers and were more likely to die from aggressive forms of these diseases.

«Building upon previous data related to the PRSS1 mutations found in patients with early - onset pancreatitis, we learned that combined with our current data, patients with PRSS1 are more likely to have an aggressive disease course,» said Giefer.

The study evaluated 56 patients with ovarian clear cell adenocarcinoma (CCA), an aggressive form of ovarian cancer that is more likely to be resistant to chemotherapy and to have a poorer prognosis than other forms of this disease.

By age 80, more than 50 percent of men will develop prostate cancer but not all will have the aggressive, deadly form of the disease.

These are indications that areas of diseased tissue could be dying, while other parts of a tumor could be rapidly growing or becoming more aggressive.

The authors stressed that the long - term reduction in aggressive disease was observed only in men after more than a year of testosterone use, and the risk of prostate cancer did not differ between gels and other types of preparations.

This is especially concerning because radiation therapy is increasingly being used after mastectomy as a way to further reduce the risk of the cancer returning in women with more aggressive or advanced disease.

The report considers whether a recent trend of fewer men being screened may be contributing to the rise, or whether the disease has become more aggressive — or both.

More otters means more chances for disease transmission, for example, or for aggressive conflMore otters means more chances for disease transmission, for example, or for aggressive conflmore chances for disease transmission, for example, or for aggressive conflict.

Professor Nick Talbot, Professor of Molecular Genetics and expert in plant diseases, said: «The strategy of introducing less aggressive microbes to fight more aggressive ones may prove effective to control some crop disease, but our study shows that they are not a silver bullet and caution needs to be exercised.

Seventy - five percent of these cases are classified as high grade serous type, and they show more advanced disease at diagnosis and are more aggressive.

It also gives us a marker of disease that might prove valuable in the clinic to predict which patients have a more aggressive cancer.

Geneticist Xiao - Jiang Li and colleagues recently published a paper in Cell Reports that may explain why more aggressive juvenile - onset forms of polyglutamine diseases have different symptoms and pathology.

As this variant also appears to be associated with the development of more aggressive prostate tumors, a diagnostic test for the variant may enable doctors to make more informed decisions as to how closely they should monitor those who are at high risk, and how aggressively they should treat the disease once it presents.

Men with BRCA1 / 2 mutations who develop prostate cancer tend to develop these cancers at an earlier age than average and may develop more aggressive forms of the disease.

«This would be useful and important,» he said, «because physicians could decide to switch or modify therapies if they know whether the patient is likely to have an aggressive course of disease, or a more benign course.»

Men with these mutations are more likely than non-carriers to contract aggressive, lethal prostate cancer, to be diagnosed at a more advanced stage and to ultimately die of the disease, researchers say.

They found that when an MS - like disease was induced in mice genetically engineered to be deficient in Tob1, the mice had significantly earlier onset compared with wild - type mice, and developed a more aggressive form of the disease.

A small, phase 1 trial, published early online in the journal Radiology, found that this approach, designed to treat just the diseased portion of the prostate rather than removing or irradiating the entire gland, is safe and can be performed without the troubling complications associated with more aggressive therapies.

They identified a signalling protein that was frequently mutated in more aggressive subsets of the disease.

Carriers of germline mutations in BRCA2 have at least five times greater risk of prostate cancer and frequently develop a more aggressive form of the disease.

Although most of the variants individually confer moderate risk, they are common and some are linked to more than less aggressive disease.

But to really stand a chance against this aggressive disease, we should focus on more interdisciplinary collaboration.

While men with the more aggressive form of the cancer make up about 5 % of the 180,000 to 200,000 cases of prostate cancer in the U.S. each year, and only 12 % will have these mutations, that population is still at considerably higher risk of developing advanced disease.

«Studies show that people who are low in vitamin D are at greater risk of developing MS, as well as having more frequent relapses and a more aggressive progression of the disease,» Kalb says.

The findings also hint that in coming years, it may be possible to use the panel not just among men with advanced disease but to distinguish between men who develop the slower growing type of prostate cancer from the more aggressive type.

«Now rheumatologists are more aggressive at treating the diseases — because we can be,» he says.

One reason may be that men in the study seemed to develop Alzheimer's at a younger age than women and had a more aggressive form of the disease.

The report considers whether a recent trend of fewer men being screened may be contributing to the rise, or whether the disease has become more aggressive — or both.

Rabies spreads through the saliva of the infected animal, and rabid animals are much more likely to attack because the disease makes them aggressive.

The visceral forms of this disease require more aggressive treatment, and even then, the treatment will not likely be curative.