Men with BRCA1 / 2 mutations who develop prostate cancer tend to develop these cancers at an earlier age than average and may develop
more aggressive forms of the disease.
They found that when an MS - like disease was induced in mice genetically engineered to be deficient in Tob1, the mice had significantly earlier onset compared with wild - type mice, and developed
a more aggressive form of the disease.
Carriers of germline mutations in BRCA2 have at least five times greater risk of prostate cancer and frequently develop
a more aggressive form of the disease.
One reason may be that men in the study seemed to develop Alzheimer's at a younger age than women and had
a more aggressive form of the disease.
Not exact matches
Women with the variant were at much higher risk for cancer, had
more recurrences, were often hit with multiple cancers and were
more likely to die from
aggressive forms of these
diseases.
The study evaluated 56 patients with ovarian clear cell adenocarcinoma (CCA), an
aggressive form of ovarian cancer that is
more likely to be resistant to chemotherapy and to have a poorer prognosis than other
forms of this
disease.
By age 80,
more than 50 percent
of men will develop prostate cancer but not all will have the
aggressive, deadly
form of the
disease.
Geneticist Xiao - Jiang Li and colleagues recently published a paper in Cell Reports that may explain why
more aggressive juvenile - onset
forms of polyglutamine
diseases have different symptoms and pathology.
While men with the
more aggressive form of the cancer make up about 5 %
of the 180,000 to 200,000 cases
of prostate cancer in the U.S. each year, and only 12 % will have these mutations, that population is still at considerably higher risk
of developing advanced
disease.
The visceral
forms of this
disease require
more aggressive treatment, and even then, the treatment will not likely be curative.
Also, cats mount a much
more aggressive immune response against the worms than do dogs, and the resulting inflammation is responsible for much
of the damage in the feline
form of this
disease.