Sentences with phrase «more aggressive tumors»

Chemotherapy may be recommended for patients with more aggressive tumors (e.g. higher grade tumors).

Led by Cheryl Thompson, PhD, the study is the first - of - its - kind to show an association between insufficient sleep and biologically more aggressive tumors as well as likelihood of cancer recurrence.

The number of mutations within each tumor and the prevalence of the basal - like and mesenchymal stem - like subtypes — all of which suggest more aggressive tumors — was also greater in the tumors of African American patients.

«Potential pancreatic cancer target challenged: New research finds PDX1 critical for cancer growth, but blocking it may lead to more aggressive tumors.»

In their paper published online in the Journal of Clinical Oncology, the researchers report that several genetic characteristics of more aggressive tumors were significantly more prevalent in African American patients and appeared to be associated with a greater risk of tumor recurrence.

Mice that were given antioxidants developed additional and more aggressive tumors.

The researchers are now further investigating the possibility of using this approach on other cancers, including prostate cancer, where it could be used to distinguish more aggressive tumors from those that grow much more slowly, Bhatia says.

Participants with high levels of TCEP in their house dust were more than four times as likely to have larger, more aggressive tumors that extended beyond the thyroid, according to the study.

The luminal cells generally lead to more aggressive tumors.

«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.

«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the study.

Not surprisingly, the more aggressive a tumor, the more likely it is to engraft — probably because those cancer cells are particularly adept at growing and spreading.

Not exact matches

«This research represents a big step forward in understanding why some tumors are more aggressive than others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic Cancer Research at MSK, and corresponding author of the companion study in Nature.

Many biomarkers are available for estimating tumor mass, but a possibly more important aspect of a tumor's pathology is how aggressive it is and how fast it is growing.

Conventional, high - dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors» recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered.

The African American mRNA variants encode protein isoforms that make a tumor more aggressive, whereas the protein isoforms generated in European Americans appear to make the tumor less aggressive.

«Tumor cells closer to 1 were more similar to stem cells and significantly more aggressive than tumor cells closer to 0,» Malta Tumor cells closer to 1 were more similar to stem cells and significantly more aggressive than tumor cells closer to 0,» Malta tumor cells closer to 0,» Malta said.

Triple - negative tumors are aggressive and more likely to metastasize than other breast cancers, and there is no effective treatment.

«Study identifies potential treatment target for pancreatic cancer: Molecular signature found in 30 percent of PDAC tumors associated with more aggressive cancer.»

Possibly, this is because the body can recognize which tumors are more aggressive and react to them,» said Balla.

«Finding which mechanisms determine why melanoma is so aggressive is very complex because more than 80,000 mutations have been described for this tumor,» says Direna - Alonso Curbelo, the article's first author.

These are indications that areas of diseased tissue could be dying, while other parts of a tumor could be rapidly growing or becoming more aggressive.

The Cancer Vaccine Collaborative is working on treatments that target multiple cancer antigens, which should trigger a more aggressive immune response and increase the odds of defeating tumors.

By tracking and understanding which host cell pathways are manipulated by these T. gondii proteins, scientists can identify potential new targets to develop more effective therapies against highly aggressive solid tumors.

Little is known about how CNS - PNETs develop, although these tumors are more aggressive than other PNETs and have an overall survival rate of only about 20 percent.

The authors say it is plausible that smokers have pathologically more - aggressive tumors, or that smoking may decrease the efficacy of colorectal cancer treatment.

In the meantime, he adds, gaining a better understanding of aggressive NF1 - related tumors allows researchers to develop more realistic models of these cancers in the lab.

Study leader Fausto J. Rodriguez, M.D., associate professor of pathology at the Johns Hopkins University School of Medicine and member of the Johns Hopkins Kimmel Cancer Center, says the new study sought to sort out what makes the more aggressive NF1 - related tumors genetically different from low grade tumors and normal, healthy cells.

Despite the success of melanoma - targeting drugs, tumors inevitably become drug resistant and return, more aggressive than before.

Researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread.

It has been recognized that the more aggressive triple - negative breast cancer occurs more frequently in African American women, but no previous study has examined racial differences in tumor genotype and how they might contribute to the risk of cancer recurrence.

As in the knock - out mice, aggressive tumors failed to thrive and were reduced to low - grade tumors looking more like cysts; metastasis, while not completely abolished as in the knock - out mice, was reduced some 70 percent.

The results suggest that the pockets of stiffer extracellular matrix in the breasts of obese women contribute to tumor growth as well as to more aggressive cancers, Fischbach says: «People always think it's all about soluble factors, chemicals.

«Mutations are acquired over time as the tumor progresses and becomes more aggressive, more invasive, and more metastatic.

«Low oxygen, high risk: How tumors adapt to become more aggressive.»

These findings show that MAX acts as a tumor suppressor gene in one of the more aggressive types of lung cancer.

«Researcher discovers metabolite of prostate cancer drug more effective at treating aggressive tumors.»

Hypoxia, or a lack of oxygen, is one example of a phenomenon that should weaken the tumor, but instead, the malignant cells are able to compensate and drive more aggressive disease behavior.

Certain kinds of tumors have been found to be more aggressive and associated with less than favorable prognoses compared to others.

But the other tumor types may require more aggressive measures to prevent relapse, including chemotherapy and sometimes investigational drugs.

As this variant also appears to be associated with the development of more aggressive prostate tumors, a diagnostic test for the variant may enable doctors to make more informed decisions as to how closely they should monitor those who are at high risk, and how aggressively they should treat the disease once it presents.

However, unfortunately the mechanisms of tumor cells have the ability to resist to immunotherapy and patients who relapse with acquired resistance to BRAF and MEK inhibitors often present with melanomas that display a much more aggressive and invasive phenotype [13, 14].

The researchers found that non-Hispanic white women were more likely to have smaller tumors, and more likely to have the less - aggressive HR + / HER2 - subtype of breast cancer, compared with African - American women, who were more likely to have large tumors, more likely to have the aggressive triple - negative breast cancer, and 40 to 70 percent more likely to be diagnosed at stage 4 of all subtypes of breast cancer.

Mutations in the beta - catenin gene, or flaws in the factors that degrade it, have long been linked to more aggressive disease in various tumor types, including colon, lung and prostate cancer, and melanoma.

Rudensky's team compared Tregs in normal human breast tissues with those found in untreated breast tumors, and found that Tregs in tumors were capable of more potent and aggressive immunosuppressive action.

It has been postulated that hypoxia contributes directly to the development of more aggressive cancers by exerting selective pressure on the tumor cell population to favor cells that can survive decreased O2 and nutrients [18 — 20].

In addition, our investigators have used epigenetic biomarkers to: develop screening tests for cancer; help guide surgeons in removing cancerous tumors; predict drug resistance; and, pinpoint more aggressive cancers.

It can make a difference, for example, if community members know that tumors may be more aggressive in certain populations.

«Tumor cells closer to 1 were more similar to stem cells and significantly more aggressive than tumor cells closer to 0,» Dr. Malta Tumor cells closer to 1 were more similar to stem cells and significantly more aggressive than tumor cells closer to 0,» Dr. Malta tumor cells closer to 0,» Dr. Malta said.

Since completing the initial paper published Thursday, the team has analyzed 50 more samples from eye fluid of retinoblastoma patients, including those with less aggressive tumors whose eyes were saved, to get a start on determining what factors might be at play in tumor progression.