Sentences with phrase «more cell changes»

When this zygote goes through more cell changes and divisions and attaches itself to your uterus wall, your developing baby reaches the embryonic stage.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

... yeah suzy and others... I just happen to realize that when monkey devolving didn't quite work out on paper it all changed to single cells and from the slime off of the worlds garbage can and so on... I just happen to know more than you think... In another ten or twenty years the science books will all have a new teaching... the Bible has been around and hasn't changed one word in over two thousnad years..

A clump of cells with no brain, and no neural tube is no more «a human life» than cells from your skin layer, or a sperm cell with no change of fertilizing an egg.

This module is developed for customers that want the benefits from using Eilersen digital load cells but can not change existing equipment designed for analog strain gage load cells [more]

Caucasian babies are more prone to experience changes in eye color as their skin cells gradually build up melanin.

While you are making adjustments for your changing shape, there are a lot of changes going on inside your womb as your baby, who was just a cluster of cells a couple of months ago, has organs, nerves, muscles and is looking more like a little person.

The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, 53

Scientists must seek a new, more energetic engagement with Americans if they are to overcome public skepticism on issues ranging from climate change to stem cell research, AAAS CEO Alan I. Leshner writes in a commentary in The Chronicle of Higher Education.

When compared to other religious groups, Evangelicals have often been more wary of science as evidenced in debates about evolution, stem cell research, and climate change.

The researchers attribute this decrease to the way that microgravity changes the interaction between blood vessel capillaries and red blood cells, but say that more research is needed to understand what is happening in the capillaries.

Other researchers have tried changing cell behavior by creating protein switches from scratch, but Lim's approach — mixing and matching naturally existing proteins — may be more versatile and practical: «It can be useful as a biotechnology device or for repairing cells in humans.

But something did change about 800 million years ago, and cyanobacteria and other minute organisms in continental margin ecosystems got more phosphorus, the backbone of DNA and RNA, and a main actor in cell metabolism.

Zika induced changes that were more focused on genes involved on DNA replication and repair, indicating that Zika infection disrupts cell replication more.

The results show — for the first time, Briggs thinks — that the bacterial genomes change with depth: the micro-organisms at 554 metres carry more mutations in genes that code for energy - related processes like cell division and biosynthesis of amino acids than are seen in their shallower counterparts.

When exposed to cold, clusters of cells within the body's white fat become beige — a color change that reflects the creation of more energy - producing mitochondria, cellular components that enable cells to burn calories and give off heat.

In contrast to the conversion of alpha cells, which only concerns a small fraction of the alpha cell population, the new mechanism involving delta cell fate change is a more efficient way of offsetting the loss of beta cells and thus diabetes recovery.

These changes make the multiple myeloma cells more aggressive.

Identifying changes in the mitochondrial DNA in PPN cholinergic neurons has the potential to allow the development of more effective treatments targeted to specific cell - types.

And his group has applied for funding to run lab studies to see if the fish hosting blotchy lesions develop more subtle — and disturbing — symptoms with time, such as a slower swimming speed or changes in blood - cell counts.

(Blaser's group reported earlier this month in Cell that giving mice penicillin soon after birth changed their gut microbiome and made them much more likely to be obese as adults.)

«This appears to be because immune cells from the joints of rheumatoid arthritis patients are more committed to inflammation, and therefore less likely to change, even though they have all the machinery to respond to vitamin D.»

Holdcroft believes that the changes in the brain are more likely to be the result of changes in the volume of individual cells, rather than changes in the number of cells in the brain.

The TERT promoter mutation does not generate enough telomerase to immortalize the pre-cancerous cells, but does delay normal cellular aging, Hockemeyer said, allowing more time for additional changes that turns telomerase up.

But something more significant than the changes in cell number is also going on.

They also plan to evolve the chemistry behind the materials so that it may be possible for gels to better mimic more complex cellular environments beyond the control of stiffness alone, as well as investigate how dynamic changes in matrix properties — a hallmark of the stem cell niche — can be mimicked in the laboratory.

Regulatory changes, under which the Japanese government allowed the distribution of iPS cells for clinical use, also prompted researchers to switch the study to a more efficient process of using cells from third - party donors instead of using a patient's own cells.

Each cell type can be distinguished based on its transcription factors, and a cell can in certain cases be directly converted from one type to another, simply by changing the expression of one or more transcription factors.

The findings, published Sept. 20 in the Journal of Virology published by the American Society for Microbiology, were publicly revealed almost simultaneously with those from China - based scientists who found a change of a single amino acid made the virus more dangerous to developing brain cells.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

«Most aging cells develop genomic changes that make them more susceptible to the carcinogens in the environment,» says oncologist Lodovico Balducci, who studies and treats cancer in the elderly at the Moffitt Cancer Center in Tampa, Fla..

As a factor becomes more concentrated in a cell, it will begin to activate genes that it has less intrinsic affinity for, potentially changing the cell's behavior.

FlaB appears to be especially good at activating a secondary molecule, TLR5, that seems to make immune cells more aggressive, «changing them from Dr. Jekyll to Mr. Hyde,» the researchers wrote.

This is more than a mere change of color, as the researchers also found that these bile acids increase the number of mitochondria in the new fat cells.

In last week's Proceedings of the National Academy of Sciences, the researchers suggest that when the enzyme is knocked out the prostate cells may be more prone to cancerous changes.

In adults, more cannabinoids will force one group of cells to more intensive work, but at the same time it will weaken the efficiency of the other, and in consequence blood glucose level will not change or may even increase significantly.»

He argued that unlike stem cell research, whose detractors» religious motivations are more clear, evangelicals who deny climate change are being deliberately misled by the religious right juggernaut.

«Our next step is to find out more about how we can vary the size of the embryoid body by changing the printing and structural parameters, and how varying the embryoid body size leads to «manufacture» of different cell types» adds Rui Yao, another author on the paper.

The team modelled how the membrane changed, enabling LUCA's descendants to move to new, more challenging environments and evolve into two distinct types of single - celled organism, bacteria and archaea, creating the deepest branch of the tree of life.

After tracking the injected cells in the mice for more than 10 days using bioluminescence and fluorodeoxyglucose (FDG)- positron emission tomography (PET) imaging, they found that the injection of the senescent cells into the knee region caused leg pain, impaired mobility and characteristics of osteoarthritis, including damage to surrounding cartilage, X-ray changes, increased pain and impaired function.

If so, it could make cell fate more resilient to random mutations in a plant's genetic code, even when such changes keep some gene - regulating proteins from binding their intended DNA targets.

The images show how a growth factor caused cells to change forms and regroup from tight packs of epithelial cells to more mobile, loose arrays of mesenchymal cells — information useful for studying cancer and wound healing.

Schaal, dean of the faculty of arts and sciences at Washington University in St. Louis, called for more effective communication and public engagement by scientists in explaining their work, both to policy makers and to the general public, across a range of topics — climate change, evolution, stem cells, and use of genetically modified organisms (GMOs) in agriculture.

But he suspects that when water washes out saliva — a salty, acidic mucus — it changes the pH within the cells, making them more likely to fire.

To investigate in more detail, researchers from KU Leuven and elsewhere employed in vitro fertilization in cattle as a flexible system to study chromosomal changes in single embryonic cells.

«Clearly, estrogen regulates TLR8 and other TLRs in ways that change the threshold of an inflammatory response, and female cells are hard wired to be more sensitive to this change,» said Nicholas Young, PhD, a molecular biologist with Ohio State's department of immunology who worked on the study.

In this way, the effect of vaccines or drugs (for example) can be tested: the more effective the active ingredient is, the smaller the number of cells that are destroyed by the viruses and the lower the measured resistance change will be.

One reason that fast - relaxing microenvironments promote more osteogenesis and form bone is that cells inside these matrices can mechanically remodel the matrix and more easily change shape, said Ovijit Chaudhuri, former postdoctoral fellow in the Mooney lab and co-first author.

«The apparent ability to change immunosuppressive T cells within the tumor into T cell types that are more active and potentially helpful against cancer was a really exciting finding, and one that we're continuing to investigate,» says Poznansky, who is an associate professor of Medicine at Harvard Medical School (HMS).