Not exact matches
(On a
cellular level, the delta - ray pattern of
damage is
more like that of X-rays or gamma rays.)
They found that by attaching to a mitochondrial protein called TOM20, alpha - synuclein prevented the mitochondria from functioning optimally, which resulted in the production of less energy and
more damaging cellular waste.
This
cellular damage may be a
more accurate indication of our biological age than the number of years since we were born.
Based on the previous evidences, it rusults important to maintain
cellular NAD + availability especially in mitochondria when stresses induce a major consumption of NAD + and ATP and prone the organism
more susceptible to ROS
damages.
O'Shea says this may explain why people with conditions resulting in high levels of
cellular DNA
damage (e.g., cancer, chemotherapy, inflammation and aging) are
more susceptible to viral infections.
Meanwhile, the same thing goes wrong in the aging brain, bringing one
more insult to the accumulating
cellular and molecular
damage that slowly erodes the functional capacity of the aging brain, culminating in Parkinson's and other degenerative syndromes.
Several types of intracellular
damage are highly challenging — sophisticated
cellular and genetic therapies will be needed to combat them, which are surely at least 20 years away and maybe much
more.
This DNA becomes
damaged in the course of normal
cellular processes, and certain forms of mitochondrial DNA
damage - to the thirteen genes needed for oxidative phosphorylation - produce malfunctioning mitochondria that can overtake their cells, either by replicating
more readily or being
more resistant to quality control mechanisms.
Electrolytes (a fancy name for micronutrients) are depleted rapidly, while antioxidants (such as vitamins A, C, E, CoQ10 and alpha lipoic acid) are utilized
more quickly, in order to reduce the
cellular oxidative
damage caused by exercise.
Glycated proteins and
cellular structures have altered function, increased vulnerability to oxidative
damage, and reduced degradation and clearance.6 Slowing the entry of glucose into the brain would delay these processes and possibly give the body's defenses
more time to dispose of the AGEs.
The
more intense the training and the
more overload placed on our body, the
more cellular muscle
damage we cause.
What starts this process is some insult — too many calories, smoking, a sunburn, exposure to toxins, anti-nutrients, sugar, and
more — that tips the balance starting a chain reaction of
cellular and tissue
damage.
A review published in «Antioxidants Sport Nutrition» in 2015 also notes that green tea's antioxidant activity may be especially beneficial for preventing
cellular damage caused by exercise, since your body burns
more calories and creates
more free radicals during exercise.
If you have inflammation inside your body, there is a greater increase in the free radical
damage and if there is inflammation, inflammation is also related to
cellular damage because the cell membranes around your cells are
more permeable to allowing bad things in and allowing good things out.