Sentences with phrase «more cellular proteins»

Not exact matches

Burke predicts more fluorescent proteins and dyes that indicate cellular events (e.g., neurotransmission) will make real - time, rapid imaging appealing to many scientists.

For instance, Evan's blue, a dye that stains the cellular protein albumin, penetrates the brain 10 times more efficiently in stressed mice than in unstressed mice.

Because they act while embedded within the cellular membrane, transmembrane proteins have proven to be more difficult to study than proteins that operate in the watery solution that make up the cells» cytoplasm or in the extracellular fluid.

After more than six years of research, the research team led by María Soengas, head of CNIO's Melanoma Group, showed that RAB7 acts as an orchestra director, determining the fate of melanoma cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout the body.

Once considered nothing more than a cellular courier, RNA turns out to be astonishingly versatile, not only encoding genetic information but also acting like a protein.

What's more, only a very small percentage (6 %) of proteins encoded by Pandoravirus salinus are similar to those already identified in other viruses or cellular organisms.

The latter are more easily accessible to the cellular machinery that translates genes into their protein products.

They found that by attaching to a mitochondrial protein called TOM20, alpha - synuclein prevented the mitochondria from functioning optimally, which resulted in the production of less energy and more damaging cellular waste.

«Single enzyme's far - reaching influence in human biology, disease: Enzyme Fam20C chemically modifies more than 100 different secreted proteins, thus directing numerous cellular processes.»

The researchers found that the more aggressive the cancer, the higher the expression of this protein, which helps maintain cellular stability.

Previous studies in the lab showed that once HCMV is inside the cell, it quickly becomes latent by entering the cell's nucleus and co-opting a cellular protein called Daxx — part of the intrinsic immune system — to shut down its own replication, the process of reproducing its genetic material to make more copies of itself.

By fiddling with the cellular postal codes that direct proteins to the appropriate destination, they inserted a more efficient mannosidase and engineered a yeast strain with glycoproteins containing far fewer mannose groups, they reported earlier this year.

«Since protein synthesis is one of the most prominent hallmarks of cellular life, it shows that these new viruses are more «cell - like» than any virus anyone has ever seen before.»

A universal difference between cellular genomes is that they are far larger and have far more proteins called histones than viral genomes.

In this new paper, the researchers reveal more about that mechanism, showing that without the protective ability of BRCA1, breaks in the DNA strands go unfixed, prompting the molecule ATM kinase to activate a cellular «suicide» pathway involving a protein called p53.

In the current paper, the shapes are made up of strut - reinforced tripods, which assemble themselves from individual DNA strands in a process called â $ œDNA origami.â $ Already, at 5 megadaltons, each tripod is more massive than the largest known single protein (titin, involved in muscle contraction) and more massive than a ribosome, one of the cellular factories in which proteins are made.

For example, inflammation in brain tissue caused by either genetic susceptibility or triggered by accumulating cellular proteins and external events, such as severe concussions, will leave the brain more open to injury.

Autophagy (more specifically macroautophagy) is the process by which cellular compartments, such as membranes and organelles and also protein aggregates, are recycled back into their building blocks [122].

Hartl, a biochemist, and Horwich, a geneticist, are pioneers in the realm of cellular protein... Read more

In these tools, NanoLuc - fluorescent protein fusion shifts NLuc's bright blue luminescence to wavelenghts more friendly for cellular and in vivo imaging.

On their own, these unstable proteins might be expected to perform their cellular duties more poorly, possibly causing harm to the organism.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

Abundant cellular glucose, caused by high blood glucose levels, enable them to reproduce and generate immune - impairing proteins more prolifically.

Glycated proteins and cellular structures have altered function, increased vulnerability to oxidative damage, and reduced degradation and clearance.6 Slowing the entry of glucose into the brain would delay these processes and possibly give the body's defenses more time to dispose of the AGEs.

As cells become more insulin resistant, the pancreas faithfully cranks out even more insulin, causing levels of C - reactive protein to rise in the body — which triggers cellular inflammation.

Large amounts of this protein create a cellular matrix, or a scaffolding, to which other structural proteins attach themselves to reform the wound, including more collagen itself.

The more mitochondria we have, and the better they work, the better the cellular infrastructure for cranking out new proteins to GROW.

Well, it could be that the supplements are full of amino acids and phytonutrients that are amazing for the overall health of the body (which naturally improves the health of the skin) or it could be that the specific amino acids that the collagen protein are utilized to produce more collagen — again, the jury is still out at the cellular level.