Sentences with phrase «more cytotoxic»
On average, in comparison with GO, IMGN632 was 70-fold more cytotoxic to AML progenitors and only fivefold more cytotoxic to normal myeloid progenitors.
http://www.bloodadvances.org/
Unexpectedly, X-ADC treatment was > 40-fold more cytotoxic to the normal myeloid progenitors than IMGN632 (median IC90 values of 45 pM vs 1900 pM, respectively, in matched samples).
Not exact matches
«These new results are significant because they represent the discovery of a number of more potent variations of the natural product as cytotoxic agents against cancer cells,» Nicolaou said.
Thus, the molecule's observed «effect» on cell growth is nothing more than the well - known cytotoxic effect of alcohol.
New research from La Jolla Institute for Allergy and Immunology lays the groundwork to parse how the virus interacts with its host and causes disease by pinpointing CD8 + T cells, a subset of T cells more commonly known as cytotoxic or killer T cells, as important gatekeepers that control Zika infection or limit the severity of disease.
Our data suggests that targeting DGKζ could prove to be a more useful clinical approach to augment cytotoxic T cell activity against tumor than targeting Cbl - b, perhaps resulting from enhanced Ras / ERK signaling.
Furthermore, they may be cytotoxic or may instead exert an anticancer effect by acting on one or more aspects of the tumor microenvironment either alone or in combination with existing anticancer treatments [3, 4].
Lung cancer treatment is an evolving field of science, currently there are several pathways under investigation as a possible treatment target.1 - 3 Targeted treatment is currently considered to be more efficient compared to the non-specific cytotoxic drugs, however; the small number of patients identified with mutations, limit the application of these drugs.
Mice and human volunteers who underwent cycles of the Fasting Mimicking Diet had decreased numbers of myeloid cells, the inflammatory immune cells that become more numerous as we age, and increased numbers of cytotoxic T cells, which protect the body against viruses and cancer.
Despite similar mechanisms of action between CsA and tacrolimus, tacrolimus has been demonstrated to be 10 to 100 times more potent than CsA in its ability to inhibit cytotoxic T lymphocytes and production of IL - 2, IL - 3 and gamma interferon in vitro.