In a culture dish microglia that were modified to make a lot of TREM2 gobbled more amyloid and removed
more dying neurons, compared with microglia having less of the protein.
Not exact matches
Svendsen is
more optimistic about his team's work involving human tests of a novel stem cell approach to treat ALS, a degenerative motor
neuron disease in which cells that transmit messages from the brain and spinal cord to the muscles wither or
die.
However, Markus Butz stresses that this does not work without a certain minimal excitation of the
neurons: «A
neuron that no longer receives any stimuli loses even
more synapses and will
die off after some time.
When the brain is harmed by injury or disease,
neurons often
die or degenerate, but glial cells become
more branched and numerous.
And we know much
more about what can go wrong in the brain that causes motor
neurons to
die.
And when they tracked the striatal
neurons carrying the mutant huntingtin over time, they found them much
more likely to
die than those from other brain regions.
This work is based on his previous research showing that a specific type of
neuron that
dies in Parkinson's disease is
more vulnerable to problems in mitochondrial fission.