Sentences with phrase «more efflux»
It had been reported that the ADEP resistance of M. tuberculosis was due to the presence of one or perhaps more efflux pumps.
https://www.sciencedaily.com/ Not exact matches
To address this challenge, our research group is using nanoparticles not only to deliver more chemotherapy drugs to the target site within cancer cells, but also to compromise the function of the efflux pumps and thereby significantly improve safety and efficacy of cancer therapy.»
«After more extensive analysis, we narrowed down our list to predict which molecules were most likely to disrupt the function of the efflux pump.»
They plan to leverage a recently awarded Innovative and Novel Computational Impact on Theory and Experiment (INCITE) allocation from DOE to perform larger simulations on the Titan supercomputer to gain deeper understanding of how bacterial efflux pumps function, identify more potent efflux pump inhibitors and optimize the best antibiotic - plus - inhibitor combinations to make them suitable for clinical trials.
Second, our current study suggests that after the long - term drug administration in mice, the more rapid recovery may also involve the interplay of ABC efflux transporters and SLC influx transporters in the testes.
Importantly, cisplatin toxicity and Pgp efflux transporter activity measured on - chip more closely mimic the in vivo responses than results obtained with cells maintained under conventional culture conditions.
The higher ice efflux, in turn, further reduces the ice compactness, thus more solar radiation is absorbed by the oceans which enhances the summer melting process.
It also shows that there is a step in the relationship, probably caused by either temperature, anthropogenic changes to the biotic capacity or more likely that the efflux of CO2 from the atmosphere is of an order greater than 1 (i.e. has a first - order and second - order reactions).