Sentences with phrase «more gene transcription»

With single - cell RNA sequencing, much more gene transcription was detected than before.

Not exact matches

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manner.

Other proteins, called transcription factors, interact with the genes more directly: They bind to landing sites situated near the gene under their control.

Genes become more or less active at the touch of proteins called transcription factors, each of which can influence hundreds or thousands of other gGenes become more or less active at the touch of proteins called transcription factors, each of which can influence hundreds or thousands of other genesgenes.

We had started working on this more than a year ago, when we tried inserting four transcription factors, which regulate genes, into the skin cells.

These are the same T cell genes inhibited by digoxin, and since replication of integrated HIV - 1 requires transcription of nearby genes, this provides an explanation for why wild type HIV - 1 is more susceptible to digoxin: digoxin represses the genes that the virus more frequently targets for integration.

Although the majority of genes related to energy production, cell division, and metabolism in M. jannaschii are most similar to those found in Bacteria, most of the genes involved in transcription, translation, and replication in M. jannaschii are more similar to those found in Eukaryotes.

The proximity and anchoring of the genes to the nuclear pores during transcription has been known of for more than a decade.

Naturally, every gene is not regulated by its own distinct transcription factor; otherwise, a codebook of as many as 30,000 genes would require 30,000 transcription factors — and 30,000 more genes to code for them.

They later showed that RORA, a nuclear hormone receptor that functions as a transcription factor, can potentially regulate the transcription of more than 2,500 genes, including over 400 genes already associated with autism.

Whereas liver and blood gene activity patterns showed the expected differences among the three groupswith human transcription looking similar to that of the chimp, and different from that of the more evolutionarily distant macaquegene activity in the brain revealed stark differences between humans and chimps.

In response to signals from inside and outside cells, transcription factors attach to the DNA and cause specific genes to be more or less activated, producing more or less of the corresponding protein.

Genes within the same TAD interact with each other more than with genes in other TADs, and domains undergoing active transcription occupy different locations in a nucleus than quiet domGenes within the same TAD interact with each other more than with genes in other TADs, and domains undergoing active transcription occupy different locations in a nucleus than quiet domgenes in other TADs, and domains undergoing active transcription occupy different locations in a nucleus than quiet domains.

Studies could include examining the activation and deactivation of genes (e.g., transcription factors or epigenetic regulation) or involve more classical genetic identification studies.

«Looking at gene expression, the ketogenic diet suppressed the longevity - related TOR pathway and insulin signaling and up - regulated the fasting - related transcription factor PPAR - alpha, a master regulator that helps the body more efficiently metabolize fat.»

A third, more basic, project in our lab concerns the transcription and splicing of very large mammalian genes.

10/10/2007 Researchers Reveal Repressor Protein Blocks Neural Stem Cell Development A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... More...

But in a recent study, researchers described a balancing act that seems more counterintuitive than most: Bacterial cells prioritize transcription — the process of making RNA transcripts of genes as the first step in protein production — over repairing double - strand breaks in their DNA.

What's more, one transcription factor typically targets thousands of genomic locations in the cell and changes gene expression at each location.

A few receptor genes have more than 8 different isoforms (38 VRs and 10 ORs), however in most of these cases this is due to the presence of several transcription start sites (TSS) or exons that differ in length by just a few nucleotides, so several of the final transcripts differ only very slightly (Figure S7B).

In fact, CH methylation within a gene correlated more highly with repression than inaccessibility of DNA to transcription machinery (as measured by the ability of a transposase to grab onto genes).

Among the 2857 common genes (CDS and ncRNA), more than 85 % of those in strain GP59 showed no significant difference in the transcription levels (< 2-fold difference in TPM)(Data S4) with their counterparts in strain JAM1.

BGEM contains images for more than 400 genes with DNA binding and / or transcription factor activity, and more than 300 genes with protein translation and protein transport activity.

More recently, a common variable number tandem repeat (VNTR) polymorphism lying 1.2 kb upstream of the transcription initiation site of MAOA has been shown to affect transcriptional activity of the gene in transfected cells.