He'd like a way to perform single - cell analysis using microarrays, instead of full sequencing, but chip - based bisulfite methods require
more nucleic acid — about a microgram — than one cell can provide.
The more nucleic acids the sequences have in common, the more closely related two cultivars are.
Even after initial purification of the sample, liquid biopsies typically contain much
more nucleic acid from healthy cells than from tumors.
Not exact matches
Says Roberts: «He quickly figured out that if Illumina was successful, it would need
more than the world's supply of oligonucleotides» — the short snippets of
nucleic acid that are designed to pair up with specific genetic sequences, and which are critical for DNA or RNA analysis.
An HPV test, in which doctors test a cervicovaginal specimen for the presence of the
nucleic acids of carcinogenic types of HPV, is
more sensitive than the Pap test (a microscopic examination of exfoliated cells) for detection of precancers.
Nucleic acid and protein sequences, as well as three - dimensional structures of proteins, are frequently the objects of study, but gene expression as well as the simulation of pathways and biochemical networks are attracting
more and
more attention.
The article in the journal Molecular Therapy —
Nucleic Acids titled «As Technologies for Nucleotide Therapeutics Mature, Products Emerge» describes the analysis of
more than 60,000 research publications related to oligonucleotide therapies.
A new
nucleic acid sequencing platform, the Sequel System, provides higher throughput,
more scalability, a reduced footprint, and lower sequencing project costs compared to the PacBio RS II System, while maintaining the existing benefits of single molecule, real - time (SMRT) technology.
It also hints at why proteins were eventually preferred by evolution over
nucleic acids as catalysts in biology: proteins offer much
more ability to «tune» their «jiggling and wiggling» and their response to chemical reactions.
The find highlights how ancient viruses can
more easily be identified by their proteins than their
more commonly studied
nucleic acids, such as DNA or RNA.
Nucleic acids and proteins trapped in ancient mummies and still
more ancient bones can serve as time capsules of history.
«We identified a set of novel microRNAs that are potent inducers of neuroblastoma cell differentiation and found that mimics (synthetic fragments of
nucleic acid used to raise microRNA levels in cells) of some of the identified microRNAs are much
more potent in inducing neuroblastoma cell differentiation than the current differentiation treatments.
To develop practical
nucleic - acid computers, scientists will have to clear some major hurdles, but Adleman is hopeful that
nucleic - acid computers will be
more than mere curiosities.
More information: Kalina Paunovska et al, A direct comparison of in vitro and in vivo
nucleic acid delivery mediated by hundreds of nanoparticles reveals a weak correlation., Nano Letters (2018).
«It involves much
more than a certain
nucleic acid sequence of DNA.»
We reasoned that contamination from XMRV - infected LNCaP cells was
more likely given that the laboratory at the Cleveland Clinic performing the
nucleic acid extractions in 2004 was simultaneously working with LNCaP and had only worked with 22Rv1
more than 2 years prior.
The co-delivery of small molecular drugs with
nucleic acids can improve gene transfection efficiency, reduce side - effects of these drugs, and achieve the synergistic effect of drug and gene therapy for the
more effective treatment of cancer.
In 1999 the
nucleic acid sequence archives contained a total of 3.5 billion nucleotides, slightly
more than the length of a single human genome; a decade later they contained
more than 283 billion nucleotides, the length of about 95 human genomes.
More recently, Mirkin lab has developed a novel version of spherical
nucleic acids, named Sticky - Flares (Briley et al., PNAS 112:9591 - 9595, 2015), which has also been patented for commercial use.
More importantly, it can deliver nucleic acids more effectiv
More importantly, it can deliver
nucleic acids
more effectiv
more effectively.
Magnesium is required for
more than 300 enzymatic reactions, including the synthesis of fat, protein and
nucleic acids, muscular contraction and relaxation, as well as cardiac and bone health.
Pine Pollen is also rich in
more exotic, albeit vitally important, compounds such as
nucleic acids (DNA - repairing fragments) and superoxide dismutase, a powerful antioxidant and cell protectant, among many others.
Such enzymes will break down sugars,
nucleic acids, amino acids, and fatty acids so that they are
more easily assimilated into the body.
Although chlorella contains less beta - carotene and protein than spirulina, yet it has
more essential fatty acids and is twice higher in the
nucleic acid and chlorophyll.
After invading the cells, papilloma viruses insert their genetic information into the host cell's DNA (
nucleic acid) and upset the normal regulatory mechanisms of cell division, so that the cell divides abnormally and
more frequently.