Sentences with phrase «more over the duration»

Because the repayment term is longer, interest has more time to add up and you can end up paying thousands more over the duration of your loan.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Total Flow Control ™, our patented airflow system, allows you to set the location and duration of the breakpoint airflow, which eliminates cold spots in the oven, resulting in more consistent product cooking and coloring, and up to a 6 % increase in product yields over other manufacturer's ovens.

It was more upsetting when I read about Usmanov wanting to loan us the debt interest free and over a longer duration so we can keep spending and investing.

Keeping up with an exercise routine over the long haul and slowly increasing intensity and duration is more beneficial than doing too much too soon.

A longer duration of breastfeeding — for example more than 12 months (and this can be over several babies) is more protective, even if you are breastfeeding at all and whether you are mixed feeding with some breast milk and some formula, your breast cancer risks are reduced.

«Other changes I think over the duration of my time being here seeing a switch to a lot more dark chocolate as compared to milk chocolate.

Finally, the draft bill includes a new funding programme, the «Descartes Fellowships,» that would reward between 100 and 150 of the best young researchers with approximately 60 % more money than the lowest wage over the award's 5 - year duration.

«Advances in numerical algorithms, automatic grid generation, and increased supercomputer power will eventually make the simulations of flood waves over large durations of time possible using Titan, and even more so with Summit,» Constantinescu said.

«Such ecological impacts are likely to have become more prevalent with the increasing frequency and duration of [marine heat waves] over the last century.»

«Our results show that increased PsbS expression allows crop plants to be more conservative with water use, which we think will help to better distribute available water resources over the duration of the growing season and keep the crop more productive during dry spells.»

Due to the ability of black cells to capture solar radiation from low angles, they generate more electricity already over the duration of one day as compared to the traditional cells.

Compared with the general population, and after controlling for confounding factors (such as disease duration, other co-existing diseases and socio - economic factors), patients with RA actively on TNF inhibitor treatment were 50 percent more likely to have ACS, while those who had never taken these medications were over twice as likely to have ACS.

Even more promising, it also reduced the duration of common colds by over a day on average.

While drinking enough water may be a simple enough goal during short runs, a much more in depth plan is needed when performance over an extended duration in the heat is the goal.

The crucial component, in this situation, is L - arginine, is still passed over to the feast for the duration of the built - up course, so this too will advance body fluid flow and make available a more solid sexual erection.

While a watchable finale is far cry from the greatness with which the film flirts for a considerable portion of its duration, Minority Report is still top - notch summer entertainment, delivering the requisite thrills while offering something a little more to chew on once it's over.

In the latest analysis we've produced in partnership with our good friend, Professor Tammy Kolbe of the University of Vermont, we found on these two basic questions that, among non-charter schools, the length of the school day has increased slightly over the last few years to 6.8 daily hours — and a bit more among charters — while the duration of the school year has remained consistent at 179 days.

Professional development programs with more than 14 hours in duration and delivered over time are most effective at changing teacher practice and improving student achievement.

That's okay, because when you conduct an article marketing campaign, you're usually committing to marketing more than one article over a longer duration.

He's pretty sure he has some traits of autism, because he's been constantly working and obscenely prolific for the entire duration, writing over a hundred screenplays and TV pilots, which he's adapting into forthcoming books, because these days very few people are willing to turn throw money at him to put his... [Read more...]

Even though this means a lower monthly payment, the total amount you pay in interest over the entire duration of your loan will likely be more.

These ETFs, now available for the municipal, corporate and high yield sectors, enable more precise control over duration risk than previous fixed income ETF offerings.

If you want more protection against rising rates, you can go with a short - term bond fund — for example, Vanguard Short - Term Bond index fund has a duration of just over 2.7 years — or you could split your bond stake between a total bond market and a short - term bond index fund.

Rising rates could, over time, help restore the attractiveness of lower - risk government and shorter - duration debt — at the expense of more richly valued credit sectors that have benefited from the hunt for yield in recent years.

The thing that many people don't realize is that while the payment and the interest are low, the bank neglects to advertise the fact that the duration is so long that over time you end paying way more in interest fees.

When the bank offers lower monthly payments, however, it will definitely be compensated with a longer duration and more interest accumulated over time.

A long - term rate would mean that the prime mortgage rate Canada is for a longer duration may be spread over 10 years or more.

John Miller, fund manager and co-head of fixed income at Nuveen, says that the funds» performance is driven not so much by duration or yield - curve positioning, but more by yield, credit selection and bonds that have the opportunity for credit spreads to narrow over time.

While I was able to sell the June strike for just over $ 6.00 the January strike (that's seven months longer, more than twice the duration for those of you who might be calendar challenged) looks like it would sell for around $ 9.00.

Data from Cerulli and BlackRock also shows bond ETF use generally «starts with broad - based core holdings,» but over time sophisticated users of bond ETF products may shift to more specialized investment objectives, such as managing sector exposure, duration, maturities, and credit risk according to unique client needs.

Put $ 2,000 down on a five - year loan (the average length of most auto loans) at 5.9 % and you'll shell out $ 840 more in interest over the duration of the loan than a dealer - financed borrower who locks in 4.2 % and around $ 2,820 more than a buyer who scores a 0 % interest rate.

If a less specific group of bonds can be delivered to create a new unit, i.e., the bonds must satisfy certain constraints on issuer percentages, issue sizes, duration [interest rate sensitivity], convexity [sensitivity to interest rate sensitivity], sector percentages, option - adjusted spread / yield, etc., then arbitrage can proceed more rapidly, and premiums over NAV should be smaller.

World Travel Awards recipients are decided by travel industry professionals from more than 140 countries who cast more than a million votes over the duration of the campaign.

So once the exclusivity duration is up for a title, why the hell wouldn't a developer take a couple of days to port the game over to Windows, so they could easily sell thousands of copies more?

Ultimately, this makes for a much more relaxed affair than most games and when coupled with the lack of fail state in the game, Fragments of Him just over two hour duration makes it an easily digestible prospect if not one that represents especially good value for money.

If you'd like to learn more about Hero Generations, go check out their Kickstarter campaign - well on its way with over half the duration remaining - or their Steam Greenlight page and consider showing your support!

Anyone who contributes more than the current average of $ 9.75 will also receive Freedom Planet (Wii U), Rhythm Thief and the Emperor's Treasure (3DS), Citizens of Earth (Wii U / 3DS) and a Retro City Rampage: DX Home Theme for the 3DS, with more titles to come over the duration of the sale.

TIME 100: The People Who Shape Our World KIKI SMITH Delighting in the Debased By CHUCK CLOSE Thursday, May 4, 2006 In the face of an era (now more than 25 years in duration) dominated by appropriation over invention and innovation, what are we to make of the career of Kiki Smith?

More recently, Boelens has made a series of large - scale photograms, using various objects or textiles that are folded repeatedly over the duration of the exposure and create radiant fields of color.

The space would go on to host three more exhibitions over its short duration which was only about four months — closing with the end of Linda's academic semester in India.

For the duration of the festival, which runs until Oct. 28, two of the tanks (the third is used for offices) will be given over to performance work by more than 20 artists, including a reworking of the choreographer Anne Teresa de Keersmaeker's 1982 «Fase»; a three - week residency by the Cuban artist Tania Bruguera; an examination of ground - breaking figures in experimental film; and, in the space known as the East Tank, a commission from the Korean performance artist Sung Hwan Kim.

Surely you have more to present than that to support your claim, ``... the duration of the current positve phase of the PDO over the last 30 years... can very much be linked (albeit not with absolute certainty) to anthropogenic global warming.»

Seems to me the debate about AGHG global warming and increasing TC frequency / intensity / duration boils down to the fact that as sea surface temperatures, as well as deeper water temperatures rise, the wallop of any TC over warmer seas without mitigating circumstances like wind sheer and dry air off land masses entrained in the cyclone will likely be much more devastating.

Due to the ability of black cells to capture solar radiation from low angles, they generate more electricity already over the duration of one day as compared to the traditional cells.

But if there is no long lasting step change coincident with the 2015/16 strong El Nino, by 2019/20 the «pause» will then be well over 21 years in duration, possibly even 25 years in duration, and one can expect to see ever more papers putting Climate Sensitivity at ever lower levels.

The models heavily relied upon by the Intergovernmental Panel on Climate Change (IPCC) had not projected this multidecadal stasis in «global warming»; nor (until trained ex post facto) the fall in TS from 1940 - 1975; nor 50 years» cooling in Antarctica (Doran et al., 2002) and the Arctic (Soon, 2005); nor the absence of ocean warming since 2003 (Lyman et al., 2006; Gouretski & Koltermann, 2007); nor the onset, duration, or intensity of the Madden - Julian intraseasonal oscillation, the Quasi-Biennial Oscillation in the tropical stratosphere, El Nino / La Nina oscillations, the Atlantic Multidecadal Oscillation, or the Pacific Decadal Oscillation that has recently transited from its warming to its cooling phase (oceanic oscillations which, on their own, may account for all of the observed warmings and coolings over the past half - century: Tsoniset al., 2007); nor the magnitude nor duration of multi-century events such as the Mediaeval Warm Period or the Little Ice Age; nor the cessation since 2000 of the previously - observed growth in atmospheric methane concentration (IPCC, 2007); nor the active 2004 hurricane season; nor the inactive subsequent seasons; nor the UK flooding of 2007 (the Met Office had forecast a summer of prolonged droughts only six weeks previously); nor the solar Grand Maximum of the past 70 years, during which the Sun was more active, for longer, than at almost any similar period in the past 11,400 years (Hathaway, 2004; Solankiet al., 2005); nor the consequent surface «global warming» on Mars, Jupiter, Neptune's largest moon, and even distant Pluto; nor the eerily - continuing 2006 solar minimum; nor the consequent, precipitate decline of ~ 0.8 °C in TS from January 2007 to May 2008 that has canceled out almost all of the observed warming of the 20th century.

In medium to long duration marriages our Vancouver Cross Over Spousal Support are aware that a cross over of support formula occurs when all children are adults and no more child support is payaOver Spousal Support are aware that a cross over of support formula occurs when all children are adults and no more child support is payaover of support formula occurs when all children are adults and no more child support is payable.

Another advantage of a life insurance policy is that you have great flexibility over what company you choose, the policy, coverage, duration, beneficiary, and more.

Nurse - based home - visiting programs tend to have better staff retention compared with those that employ paraprofessionals, perhaps contributing to program effectiveness.26, 27 Likewise, programs in which paraprofessionals remained involved over a 2 - year time period were more likely to demonstrate effectiveness than those with shorter durations of involvement.28