Sentences with phrase «more possibilities due»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Other risks and uncertainties include the timing and likelihood of completion of the proposed transactions between ILG and MVW, including the timing, receipt and terms and conditions of any required governmental and regulatory approvals for the proposed transactions that could reduce anticipated benefits or cause the parties to abandon the transactions; the possibility that ILG's stockholders may not approve the proposed transactions; the possibility that MVW's stockholders may not approve the proposed transactions; the possibility that the expected synergies and value creation from the proposed transactions will not be realized or will not be realized within the expected time period; the risk that the businesses of ILG and MVW will not be integrated successfully; disruption from the proposed transactions making it more difficult to maintain business and operational relationships; the risk that unexpected costs will be incurred; the ability to retain key personnel; the availability of financing; the possibility that the proposed transactions do not close, including due to the failure to satisfy the closing conditions; as well as more specific risks and uncertainties.

There is a real possibility you can pay more in taxes in retirement than when working due to a loss of deductions like college loans and mortgage interests, as well as if you have a healthy nest egg due to minimum required distributions and social security combined.

A large part of the difference between scientists and the general population may be due more to religious upbringing, rather than scientific training or university pressure to be irreligious, although these other possibilities should be further explored.»

Had those who drew and ratified the Due Process Clause of the Fifth Amendment or the Fourteenth Amendment known the components of liberty in its manifold possibilities, they might have been more specific.

Time for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal for a club of this size and financial might... the fact that we could find money for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business model needs a complete overhaul... for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business model was that of a «selling» club... does it really make sense that we could only make a cheeky bid for Suarez, or that we couldn't get Higuain over the line when he was being offered up for half the price he eventually went to Juve for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...

In the days where games really did come thick and fast, rather than being a figment of manager and commentator imagination, high scoring matches were quite common; possibly due to players being more liberal in their festive celebrations at a time away when the possibility of twitter and facebook exposure was not a threat.

Personally Antoine is my top priority for the wide left role, mainly due to fact he gets a number of goals and with the possibility of Arsene not buying a striker this season, goals from midfield will be more important than ever.

The Democrat on the ballot had lost to the incumbent in 2006 and had a reputation as a decidedly unpleasant person, but she still ended up winning and beating a popular Republican challenger in 2008, partly due to his having difficulty convincing voters he would be any better and partly due to two more conservative candidates hopping into the race — both very real possibilities for Republicans in 2010.

Also lurking in the background is the possibility of more than $ 1 billion a year in new city costs due to proposals from Gov. Andrew Cuomo to cut state funding to Medicaid and the City University of New York.

Though high - volume hydraulic fracturing in Michigan is limited today, the U-M study takes into account the possibility that it could become more widespread due to a desire for job creation, economic growth, energy independence and lower - carbon fuels.

It reveals that two known faults adjacent to the canal are far more active than previously thought, raising the possibility of a major quake just as the canal is being widened and upgraded in a project due for completion in 2014.

In the past few years, some astronomers have entertained the possibility that these superbright galaxies aren't due to mergers but are true powerhouses, somehow continuing to suck in dust and gas from the surrounding universe to form stars over a longer period — a billion years or more.

As they spread into new areas due to changes in climate and land use, DNA can now tell us which animals will be at risk for rabies, opening up the possibility for more targeted vaccination and surveillance campaigns.»

Thomas and colleagues suggest a few ideas for future study that might help resolve the question, including the surprising possibility that tidal forces due to Saturn's gravity could be generating much more heat within Enceladus than previously thought.

Maybe that is due to the possibility my body needs more protein than «normal», or simply that I am getting more of the amino acids my body may need in greater amounts than other people?

Still, I decided to conduct a more direct test to rule out the possibility that improvements in educational outcomes were due to migration of high - performing students into APIP schools.

These advances, while making test prep more convenient for all learners, also opens up new possibilities for students who had not previously been able to participate, whether due to geography or other limitations.

Due to the small screen size, error possibility while clicking the text and links is more in smartphones and tabs; Mlearning course designers must remember this vital point while designing the course.

Likewise, the i8 Roadster's suspension tune, fabulously rigid carbon chassis, and inherent balance — due in part to the unusual engine / motor combination and layout — rewarding good driving whatever the pace, but always hinting at the possibility of more.

Is there a difference between using grease on the lug bolts for steel wheels, as opposed to alloy wheels, due to the possibility that alloy wheels may expand more than steel wheels with temperature, thus causing them to be prone to loosening lug nuts?

Due to the secured nature of home loans (the value of your property insures your loan in a way that credit cards lack) there are a lot more possibilities for borrowers with bad credit.

If you're concerned about the possibility of being unable to pay your premiums due to not being able to work for 26 weeks or more, you should consider Waiver of Premium option at the outset for an additional cost.

It also offers the possibility of easier migration to a more integrated debt / fiscal union in due course.

Other possibilities for a solution could include asking for payment due date extensions or using bank overdraft; however, these avenues can be quite costly and they don't really make the problem go away, they just create more problems.

If your cat shows any of these, speak with your veterinarian about the possibility of diabetes: Excessive thirst / drinks more water than usual (polydipsia) Urinates more frequently, in greater volumes (polyuria) or perhaps loses urinary control Consistently acts as if it is hungry (polyphagia), but maintains or loses weight Unusually sweet - smelling or fruity breath (due to ketone production) Lethargy Thinning, dry and dull hair

But there is always the possibility he may develop a need for a special, more expensive, diet due to food allergies or health issues, such as heart or kidney disease.

There are 5 difficulty levels including very easy, easy, medium, hard and realistic with the major differences between each of the difficulty levels from very easy up to realistic is that very easy A.I. will remain on a fixed racing line and are easier to overtake in comparison to realistic A.I. which provides far more aggressive A.I. that are much harder to overtake due to their faster pace and the ability to vary their racing lines to increase the possibility of overtaking their opposition, but most impressively of all is that they are equally as capable of pushing the boundaries of their pace just a little too much resulting in going off track or crashing.

The possibility of observation - model mismatch due to internal variability must also be accounted for... so in fact, attribution studies sample the range of possible forcings / responses even more completely than a climate model does.

But in analyzing the possibility of nuclear conflict as a remedy for explosive population growth it seems that there would still be a huge amount of people left, in more misery due to the sickness afterward, so it would not necessarily solve the problem.

I do see the possibility (again, as a non-scientist) of considerably more chaos arising at a regional level, particularly due to possibly chaotic changes in ocean currents.

For many, tiny homes can represent more financial freedom and a smaller environmental footprint, due to their smaller size, lower maintenance costs and the possibility of towing it onto cheap land (though any kind of mobile living can potentially have some or all of these benefits).

My understanding is if we get to a 3C increase, that will more or less guarantee we will eventually (on a geological time scale) reach 6C (due to these other «slow» feedbacks mentioned in this discussion), and the possibility of really, really bad things happening.

They don't take into account the possibility that pulses of warm sea - water may become more frequent in triggering ice - shelf collapses - or that glaciers may speed up along their base due to penetrating melt - waters.

If you have significant constraints on your time due to work, family, or personal considerations, please feel free to discuss with us the possibility of taking more than two years to complete your degree, keeping in mind that the University requires that full fees and other university expenses be paid each quarter regardless of how many units a graduate student takes.

However, what is almost certaintly true is that anything that causes OLR to decline or absorbed solar radiation to increase will warm (including internal fluctuations), and if the warming is (or was) more than estimated, it increases the possibility that warming due to anything else will also be greater than expected.

Should we avoid the possibility of such an interpretation of «due process» in Canada by using a more precise term to guarantee the rule of law?

In a sternly worded decision, the judge started by chiding the defendants, whom he states «can not contemplate the possibility that their defeat was due to the facts and the law not being on their side or, heaven forbid, that the trial advocacy of their opponents on this particular occasion was more effective than their own.»

The more recent development of AI adds a new layer of autonomy to robotic automation due to its «self - learning» capability, opening up the possibility of automating more processes.

Yes, mediation has become a more popular method of solving international trade, due to mediation having many advantages compared to lawsuits, including but not limited to: cost saving, confidentiality, the high possibility of realisation of the comprehensive and maximum interests, the maintenance of the good relationship, and benefit for the further cooperation.

It may or may not be possible for the special advocate to develop a more effective defence with more information, but the mere possibility that the defence may be compromised through a lack of information is not in keeping with the principles of fundamental justice and due process.

This difference is due to the climatic conditions of the place, possibility or risk of more accidents, thefts and many more such things.

Obviously this rate is much more than the rural rate to account for the higher possibility of auto accidents due to the higher density of people and vehicles.

While that is of course true for any cryptocurrency, due to slow mining difficulty adjustments, a potentially hostile environment, and the continued possibility for SegWit to activate on the Legacy chain after all, it's probably more true for 148 BTC.

Unfortunately there's still pretty much zero chance of Red Dead Redemption 2 coming to the Switch, primarily due to hardware limitations (we are talking about a portable here), but the fact that Take - Two seems invested in the Switch opens up more possibilities for the future.

You want to account for every possibility due to the fact there are fewer positions and more applicants.

In the Croker Island case, trial judge Justice Olney refused to grant recognition of the native title right to commercially fish due to insufficient evidence.13 With this finding (which was not supported on appeal) Justice Olney left open the possibility of claimants having these rights recognised when more compelling evidence of traditional customs of trade and barter is presented.

But to start off, choose one since it's risky enough that you are new and inexperience; you don't want to rack up more debt on top of your student loan and not to mention the possibility of failing class due to a huge amount of time is needed for real estate (do not spend hobby time on it, you'll get no where since it's actually harder to own one property than multiple).

Due to this possibility, most «buy and flip» investors need a discount of 25 % or more even after adjusting for the necessary repairs and improvement.

Due to the fact that Ms Aitken is relatively new on the job, and must of necessity establish herself as a Commissioner «to be reckoned with», I would suggest that it is not beyond the realm of possibilities that she may have been targeted by Mr. Lawrence Dale early on in her new job when he might have felt that Ms Aitken would be more easily swayed to his way of thinking.