Sentences with phrase «more potent»

A closer look revealed that ISRIB was 1,000 times more potent than many of the other molecular options.

The process generates copious amounts of nitrous oxide, a greenhouse gas 300 times more potent than carbon dioxide, while the output of methane — another potent greenhouse gas — from cattle is estimated to generate some 20 percent of overall U.S. methane emissions.

The genome of the grape used in Pinot Noir, first published in 2007, has revealed some interesting facts: For instance, the genes involved in regulating tannins, which help give wine its flavor, and for making resveratrol, the compound that supposedly gives wine its health - promoting properties, have become more potent over the centuries.

«I think, first, they are a significant concern because methane emissions are 70 percent more potent than other climate pollutants.

These chemicals can be tens of thousands of times more potent than carbon dioxide in trapping heat, so even small amounts leaking into the atmosphere could have an outsized impact on the climate.

«With the use of methamphetamine increasing, particularly more potent forms, there is a growing burden of methamphetamine related disease and harms, particularly among young people, in whom the majority of methamphetamine use occurs,» write the researchers.

New, so - called oil - in - water adjuvants could make the vaccines more potent and might stretch the limited vaccine supply, but the compounds, already in use in Europe, have not received FDA approval.

«This lymph - node - targeting modification causes pretty much all of the material to get caught in the draining lymph nodes, so that means it's more potent because it's getting concentrated in the lymph nodes, and it also makes it more safe because it's not getting into the systemic circulation,» Irvine says.

They will soon publish details of how tamandron, and related but more potent compounds, bind to androgen receptors.

In the U.S., fatal heroin overdoses have increased in the past decade by 300 percent, with fentanyl — a substance that is 20 to 50 times more potent than heroin — and its analogs increasingly contributing to overdoses.

More studies are needed to develop and test more potent CSE inhibitors.

These chemicals can be as much as 40 to 600 times more potent than THC.

The new antibiotic is at least 25,000 times more potent against microbes such as VRE and VRSA, they report this week in the Proceedings of the National Academy of Sciences.

• The main component of natural gas, methane, is a more potent greenhouse gas than carbon dioxide.

«A better understanding of this mechanism is an important step towards the development of new and more potent antibiotics,» Wilson says.

But as the rise of resistant bacteria has blunted its effectiveness, scientists have engineered more potent versions of the drug — vancomycin 2.0.

Scientists earlier described compounds that can boost ethA activity, making the drug more potent, but these have no impact on M. tuberculosis strains that have mutations in the gene and are completely resistant to the ethionamide.

OV329 binds more tightly to GABA - AT than its predecessor did — and that makes it 10 times more potent.

In the test tube experiments, SMARt - 420 made ethionamide more potent in both ethionamide sensitive and resistant bacteria, and it worked against a wide range of M. tuberculosis strains.

Milkweed plants produce varying levels of these chemicals in their leaves, and researchers wanted to figure out what makes one plant more potent than another.

Schwab, an assistant professor at NYU Langone and its Skirball Institute of Biomolecular Medicine, says similar laboratory test plans are underway for more potent CXCR4 antagonists, most likely in combination with established chemotherapy regimens.

The molecules could be more potent in actual brain tissue, so these findings may not fully capture the risks of kratom, she says.

NIH supports both innovation and «optimization that can benefit patients — such as making a cancer drug less toxic or more potent,» says Andilibi, now program director of the US National Cancer Institute's Small Business Innovation Research (SBIR) Development Center in Bethesda, Maryland.

Li Ying's group in Shanghai synthesized artemisinin derivatives that were more potent at killing malaria parasites and had more desirable chemical properties (such as solubility in water), making them better drug candidates than natural artemisinin.

«In addition, the effects of alcohol on the elderly are more potent than they are in younger individuals in part because of the pro-inflammatory state of the aged,» noted Kovacs.

Setchell and his colleagues suggest that fermented soya products — such as miso or tempeh — may be more potent than non - fermented foods such as tofu or soya milk.

«These new results are significant because they represent the discovery of a number of more potent variations of the natural product as cytotoxic agents against cancer cells,» Nicolaou said.

That may in turn have caused the planet to heat up enough to melt deposits of methane frozen in sediments on the ocean floor (something, incidentally, that could happen again), discharging even more potent greenhouse gases into the atmosphere and further heating the planet in an escalating feedback loop.

Follows the quest for more potent drugs and novel vaccines

The first nation to achieve that happy state will boast greener, safer vehicles, better homes and buildings, more potent arms and sturdier defenses, more efficient industries, and even more successful golfers, batters, and tennis players.

Any nitrogen not taken up by plants is met by soil microbes that turn the fertilizer into nitrous oxide, an ozone - depleting gas that is also 300 times more potent than carbon dioxide.

Because methane, which makes up about 95 percent of the natural gas in pipelines, is about 25 times more potent as a greenhouse gas than carbon dioxide, the leakage raises a troubling climate question: How clean is natural gas?

Understanding how bacteria overcome antibiotics could help design more potent versions.

With further study, the nano - anesthesia technique might allow more potent doses of local anesthetics to be delivered safely during local anesthesia in humans.

Instead, they provide the ideal conditions for the growth of yet other bacteria that in turn produce more potent greenhouse gases, such as nitrous oxide and methane.

Within any system there is no danger more potent, more capable of causing harm, than human frailty.

They then isolated the active compounds, studied their chemical structures and engineered more potent derivatives.

But there had been little previous research indicating that combinations of three antibiotics might be more potent together than any two of them.

I'm delighted at the prospect of a new treatment that's a lot more potent, all the more because it lowers LDL at the same time,» said study co-author Richard L. Dunbar, MD, assistant professor of Cardiovascular Medicine and member of Penn's Division of Translational Medicine and Human Genetics.

His experiment, together with a growing body of research, has revealed the profound power of disgust, showing that this emotion is a much more potent trigger for our behaviour and choices than we ever thought.

But a big question hangs over their deliberations: Can the needs of relatively powerless young researchers hold their own against the large economic and political interests at stake for far more potent elements of the university system?

Nuclear transfer — used to clone Dolly and now owned by Geron — may help scientists develop more potent stem - cell therapies

In addition to identifying certain combinations that were more potent than the researchers expected, the analysis revealed that adding a third antibiotic sometimes made the drug combination less potent — sometimes much less so, she said.

Hoping to develop a more potent approach, medical oncologist Ron Levy of Stanford University in Palo Alto, California, and colleagues used mice to test the cancer - fighting capabilities of some 20 molecules, including several types of antibodies that activate immune cells.

«We have followed a less potent neutralizing lineage in this particular individual before, but now we have found a far more potent antibody and have been able to study its development over six years,» said first author Mattia Bonsignori, M.D., of the Duke Human Vaccine Institute.

NEW DELHI — Science now has a more potent voice in India's government.

It is also a greenhouse gas 34 times more potent than carbon dioxide over the course of a century.

As temperatures warm, the Arctic permafrost thaws and pools into lakes, where bacteria feast on its carbon - rich material — much of it animal remains, food, and feces from before the Ice Age — and churn out methane, a heat trapper 25 times more potent than carbon dioxide.

It's also much more potent than previously identified inhibitors of the Zika protease.»

But when unburned methane is released into the atmosphere, it is a potent greenhouse gas with a warming potential 28 to 34 times greater than carbon dioxide over a 100 - year timeframe (and up to 84 times more potent over a 20 year timeframe).